Wilms’ tumor gene 1 in hematological malignancies: friend or foe?
ABSTRACTWilms’ tumor gene 1 (WT1) is a transcription and post-translational factor that has a crucial role in the biological and pathological processes of several human malignancies. For hematological malignancies, WT1 overexpression or mutation has been found in leukemia and myelodysplastic syndrom...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Hematology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/16078454.2023.2254557 |
| _version_ | 1797692467928104960 |
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| author | Jie Wu Hui Yan Chunli Xiang |
| author_facet | Jie Wu Hui Yan Chunli Xiang |
| author_sort | Jie Wu |
| collection | DOAJ |
| description | ABSTRACTWilms’ tumor gene 1 (WT1) is a transcription and post-translational factor that has a crucial role in the biological and pathological processes of several human malignancies. For hematological malignancies, WT1 overexpression or mutation has been found in leukemia and myelodysplastic syndrome. About 70−90% of acute myeloid leukemia patients showed WT1 overexpression, and 6−15% of patients carried WT1 mutations. WT1 has been widely regarded as a marker for monitoring minimal residual disease in acute myeloid leukemia. Many researchers were interested in developing WT1 targeting therapy. In this review, we summarized biological and pathological functions, correlation with other genes and clinical features, prognosis value and targeting therapy of WT1 in hematological features. |
| first_indexed | 2024-03-12T02:27:58Z |
| format | Article |
| id | doaj.art-7440122630eb4d47b10fdc2c2ba2d745 |
| institution | Directory Open Access Journal |
| issn | 1607-8454 |
| language | English |
| last_indexed | 2024-03-12T02:27:58Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hematology |
| spelling | doaj.art-7440122630eb4d47b10fdc2c2ba2d7452023-09-05T11:23:53ZengTaylor & Francis GroupHematology1607-84542023-12-0128110.1080/16078454.2023.2254557Wilms’ tumor gene 1 in hematological malignancies: friend or foe?Jie Wu0Hui Yan1Chunli Xiang2Department of Emergency Medicine, The Fifth People's Hospital of Huai'an and Huai'an Hospital Affiliated to Yangzhou University, Huai'an, People’s Republic of ChinaDepartment of Clinical Medicine, Medical College, Yangzhou University, Yangzhou, People’s Republic of ChinaDepartment of General Medicine, The Affiliated Huai'an Hospital of Xuzhou Medical University and Huai'an Second People's Hospital, Huai'an, People’s Republic of ChinaABSTRACTWilms’ tumor gene 1 (WT1) is a transcription and post-translational factor that has a crucial role in the biological and pathological processes of several human malignancies. For hematological malignancies, WT1 overexpression or mutation has been found in leukemia and myelodysplastic syndrome. About 70−90% of acute myeloid leukemia patients showed WT1 overexpression, and 6−15% of patients carried WT1 mutations. WT1 has been widely regarded as a marker for monitoring minimal residual disease in acute myeloid leukemia. Many researchers were interested in developing WT1 targeting therapy. In this review, we summarized biological and pathological functions, correlation with other genes and clinical features, prognosis value and targeting therapy of WT1 in hematological features.https://www.tandfonline.com/doi/10.1080/16078454.2023.2254557WT1hematological malignanciesprognosistargeting therapy |
| spellingShingle | Jie Wu Hui Yan Chunli Xiang Wilms’ tumor gene 1 in hematological malignancies: friend or foe? Hematology WT1 hematological malignancies prognosis targeting therapy |
| title | Wilms’ tumor gene 1 in hematological malignancies: friend or foe? |
| title_full | Wilms’ tumor gene 1 in hematological malignancies: friend or foe? |
| title_fullStr | Wilms’ tumor gene 1 in hematological malignancies: friend or foe? |
| title_full_unstemmed | Wilms’ tumor gene 1 in hematological malignancies: friend or foe? |
| title_short | Wilms’ tumor gene 1 in hematological malignancies: friend or foe? |
| title_sort | wilms tumor gene 1 in hematological malignancies friend or foe |
| topic | WT1 hematological malignancies prognosis targeting therapy |
| url | https://www.tandfonline.com/doi/10.1080/16078454.2023.2254557 |
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