Undercarboxylated Osteocalcin: A Promising Target for Early Diagnosis of Cardiovascular and Glycemic Disorders in Patients with Metabolic Syndrome: A Pilot Study
Lifestyle changes are causing an exponential increase in the prevalence of obesity and metabolic syndrome (MetS) worldwide. The most frequent complications of these are the development of diabetes (T2D) and cardiovascular disease (CVD). Accurate tools are needed to classify the cardiovascular risk (...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/14/2991 |
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| author | Blanca Riquelme-Gallego Laura García-Molina Naomi Cano-Ibáñez Francisco Andújar-Vera Sheila González-Salvatierra Cristina García-Fontana Aurora Bueno-Cavanillas Manuel Muñoz-Torres Beatriz García-Fontana |
| author_facet | Blanca Riquelme-Gallego Laura García-Molina Naomi Cano-Ibáñez Francisco Andújar-Vera Sheila González-Salvatierra Cristina García-Fontana Aurora Bueno-Cavanillas Manuel Muñoz-Torres Beatriz García-Fontana |
| author_sort | Blanca Riquelme-Gallego |
| collection | DOAJ |
| description | Lifestyle changes are causing an exponential increase in the prevalence of obesity and metabolic syndrome (MetS) worldwide. The most frequent complications of these are the development of diabetes (T2D) and cardiovascular disease (CVD). Accurate tools are needed to classify the cardiovascular risk (CVR) in the MetS population. In recent years, numerous biomarkers of bone metabolism have been associated with CVR. The aim of this study was to determine the levels of undercarboxylated osteocalcin (ucOC) in a cohort of patients with MetS and to analyse its association with MetS parameters and CVR as well as with T2D prevalence. A longitudinal study was conducted in which a MetS population was followed for one year. Weight change, adherence to the Mediterranean diet (MedDiet), ucOC levels, MetS parameters and CVR were analysed and CVR was calculated using different scores. Our results showed a decrease of CVR associated with a better adherence to the MetDiet resulting in higher HDL-C and ucOC levels though the improvement of MetS risk factors. This bone protein appeared as a potential biomarker to classify CVR in the MetS population, especially for MetS patients without prevalent T2D. Furthermore, ucOC serum levels could be good predictors of T2D prevalence. |
| first_indexed | 2024-03-09T10:14:26Z |
| format | Article |
| id | doaj.art-744013507f884e73b6f4003686ce0e67 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T10:14:26Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-744013507f884e73b6f4003686ce0e672023-12-01T22:32:17ZengMDPI AGNutrients2072-66432022-07-011414299110.3390/nu14142991Undercarboxylated Osteocalcin: A Promising Target for Early Diagnosis of Cardiovascular and Glycemic Disorders in Patients with Metabolic Syndrome: A Pilot StudyBlanca Riquelme-Gallego0Laura García-Molina1Naomi Cano-Ibáñez2Francisco Andújar-Vera3Sheila González-Salvatierra4Cristina García-Fontana5Aurora Bueno-Cavanillas6Manuel Muñoz-Torres7Beatriz García-Fontana8Department of Preventive Medicine and Public Health, University of Granada, 18016 Granada, SpainDepartment of Preventive Medicine and Public Health, University of Granada, 18016 Granada, SpainDepartment of Preventive Medicine and Public Health, University of Granada, 18016 Granada, SpainDepartment of Computer Science and Artificial Intelligence, University of Granada, 18071 Granada, SpainInstituto de Investigación Biosanitaria (ibs.GRANADA), 18014 Granada, SpainInstituto de Investigación Biosanitaria (ibs.GRANADA), 18014 Granada, SpainDepartment of Preventive Medicine and Public Health, University of Granada, 18016 Granada, SpainInstituto de Investigación Biosanitaria (ibs.GRANADA), 18014 Granada, SpainInstituto de Investigación Biosanitaria (ibs.GRANADA), 18014 Granada, SpainLifestyle changes are causing an exponential increase in the prevalence of obesity and metabolic syndrome (MetS) worldwide. The most frequent complications of these are the development of diabetes (T2D) and cardiovascular disease (CVD). Accurate tools are needed to classify the cardiovascular risk (CVR) in the MetS population. In recent years, numerous biomarkers of bone metabolism have been associated with CVR. The aim of this study was to determine the levels of undercarboxylated osteocalcin (ucOC) in a cohort of patients with MetS and to analyse its association with MetS parameters and CVR as well as with T2D prevalence. A longitudinal study was conducted in which a MetS population was followed for one year. Weight change, adherence to the Mediterranean diet (MedDiet), ucOC levels, MetS parameters and CVR were analysed and CVR was calculated using different scores. Our results showed a decrease of CVR associated with a better adherence to the MetDiet resulting in higher HDL-C and ucOC levels though the improvement of MetS risk factors. This bone protein appeared as a potential biomarker to classify CVR in the MetS population, especially for MetS patients without prevalent T2D. Furthermore, ucOC serum levels could be good predictors of T2D prevalence.https://www.mdpi.com/2072-6643/14/14/2991metabolic syndromecardiovascular riskdiabetesosteocalcinMediterranean diet |
| spellingShingle | Blanca Riquelme-Gallego Laura García-Molina Naomi Cano-Ibáñez Francisco Andújar-Vera Sheila González-Salvatierra Cristina García-Fontana Aurora Bueno-Cavanillas Manuel Muñoz-Torres Beatriz García-Fontana Undercarboxylated Osteocalcin: A Promising Target for Early Diagnosis of Cardiovascular and Glycemic Disorders in Patients with Metabolic Syndrome: A Pilot Study Nutrients metabolic syndrome cardiovascular risk diabetes osteocalcin Mediterranean diet |
| title | Undercarboxylated Osteocalcin: A Promising Target for Early Diagnosis of Cardiovascular and Glycemic Disorders in Patients with Metabolic Syndrome: A Pilot Study |
| title_full | Undercarboxylated Osteocalcin: A Promising Target for Early Diagnosis of Cardiovascular and Glycemic Disorders in Patients with Metabolic Syndrome: A Pilot Study |
| title_fullStr | Undercarboxylated Osteocalcin: A Promising Target for Early Diagnosis of Cardiovascular and Glycemic Disorders in Patients with Metabolic Syndrome: A Pilot Study |
| title_full_unstemmed | Undercarboxylated Osteocalcin: A Promising Target for Early Diagnosis of Cardiovascular and Glycemic Disorders in Patients with Metabolic Syndrome: A Pilot Study |
| title_short | Undercarboxylated Osteocalcin: A Promising Target for Early Diagnosis of Cardiovascular and Glycemic Disorders in Patients with Metabolic Syndrome: A Pilot Study |
| title_sort | undercarboxylated osteocalcin a promising target for early diagnosis of cardiovascular and glycemic disorders in patients with metabolic syndrome a pilot study |
| topic | metabolic syndrome cardiovascular risk diabetes osteocalcin Mediterranean diet |
| url | https://www.mdpi.com/2072-6643/14/14/2991 |
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