Respiratory microbiome: evidence from basic and clinical studies
Objective: In recent years, culture-independent methods led to provide a strong background to further microbiota studies, especially in lower respiratory tract investigation. Scientific research has focused more on studying and characterizing relationships between lung microbiota and various disease...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Verduci Editore
2023-10-01
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| Series: | Microbiota in Health and Disease |
| Subjects: | |
| Online Access: | https://www.microbiotajournal.com/wp-content/uploads/sites/7/2023/10/e873.pdf |
| _version_ | 1797368594252693504 |
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| author | V. Ankudavicius J. Skieceviciene D. Nikitina R. Lukosevicius S. Miliauskas M. Zemaitis |
| author_facet | V. Ankudavicius J. Skieceviciene D. Nikitina R. Lukosevicius S. Miliauskas M. Zemaitis |
| author_sort | V. Ankudavicius |
| collection | DOAJ |
| description | Objective: In recent years, culture-independent methods led to provide a strong background to further microbiota studies, especially in lower respiratory tract investigation. Scientific research has focused more on studying and characterizing relationships between lung microbiota and various diseases, such as lung cancer, chronic obstructive pulmonary disease (COPD), asthma, sarcoidosis, acute respiratory infection, etc.
Materials and Methods: The electronic search was performed on the PubMed database using the combination of the text words “respiratory microbiota” and “lung microbiome”. Only research studies in humans published between March 2022 and March 2023 were eligible for inclusion.
Results: The scientific search retrieved 124 results, from which 106 articles were excluded if they duplicate or did not fit the inclusion criteria. A total of 18 studies were included for review.
Conclusions: These studies have shown that changes in lower respiratory microbiota composition are a variable characteristic of all the aforementioned conditions; the relationship between circulating biomarkers, clinical data, and dysbiosis also was found in several studies. However, some studies had limitations, and future investigations are needed to better understand lung microbiota involvement in the pathogenesis of respiratory diseases. |
| first_indexed | 2024-03-08T17:34:53Z |
| format | Article |
| id | doaj.art-74458870d7564c77b31d99ad6bf52ecf |
| institution | Directory Open Access Journal |
| issn | 2704-8845 |
| language | English |
| last_indexed | 2024-03-08T17:34:53Z |
| publishDate | 2023-10-01 |
| publisher | Verduci Editore |
| record_format | Article |
| series | Microbiota in Health and Disease |
| spelling | doaj.art-74458870d7564c77b31d99ad6bf52ecf2024-01-02T13:19:19ZengVerduci EditoreMicrobiota in Health and Disease2704-88452023-10-01510.26355/mhd_202310_873873Respiratory microbiome: evidence from basic and clinical studiesV. Ankudavicius0J. Skieceviciene1D. Nikitina2R. Lukosevicius3S. Miliauskas4M. Zemaitis5Department of Pulmonology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaInstitute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, LithuaniaInstitute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, LithuaniaInstitute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, LithuaniaDepartment of Pulmonology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaDepartment of Pulmonology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaObjective: In recent years, culture-independent methods led to provide a strong background to further microbiota studies, especially in lower respiratory tract investigation. Scientific research has focused more on studying and characterizing relationships between lung microbiota and various diseases, such as lung cancer, chronic obstructive pulmonary disease (COPD), asthma, sarcoidosis, acute respiratory infection, etc. Materials and Methods: The electronic search was performed on the PubMed database using the combination of the text words “respiratory microbiota” and “lung microbiome”. Only research studies in humans published between March 2022 and March 2023 were eligible for inclusion. Results: The scientific search retrieved 124 results, from which 106 articles were excluded if they duplicate or did not fit the inclusion criteria. A total of 18 studies were included for review. Conclusions: These studies have shown that changes in lower respiratory microbiota composition are a variable characteristic of all the aforementioned conditions; the relationship between circulating biomarkers, clinical data, and dysbiosis also was found in several studies. However, some studies had limitations, and future investigations are needed to better understand lung microbiota involvement in the pathogenesis of respiratory diseases.https://www.microbiotajournal.com/wp-content/uploads/sites/7/2023/10/e873.pdflung microbiotamicrobiomelung diseases. |
| spellingShingle | V. Ankudavicius J. Skieceviciene D. Nikitina R. Lukosevicius S. Miliauskas M. Zemaitis Respiratory microbiome: evidence from basic and clinical studies Microbiota in Health and Disease lung microbiota microbiome lung diseases. |
| title | Respiratory microbiome: evidence from basic and clinical studies |
| title_full | Respiratory microbiome: evidence from basic and clinical studies |
| title_fullStr | Respiratory microbiome: evidence from basic and clinical studies |
| title_full_unstemmed | Respiratory microbiome: evidence from basic and clinical studies |
| title_short | Respiratory microbiome: evidence from basic and clinical studies |
| title_sort | respiratory microbiome evidence from basic and clinical studies |
| topic | lung microbiota microbiome lung diseases. |
| url | https://www.microbiotajournal.com/wp-content/uploads/sites/7/2023/10/e873.pdf |
| work_keys_str_mv | AT vankudavicius respiratorymicrobiomeevidencefrombasicandclinicalstudies AT jskieceviciene respiratorymicrobiomeevidencefrombasicandclinicalstudies AT dnikitina respiratorymicrobiomeevidencefrombasicandclinicalstudies AT rlukosevicius respiratorymicrobiomeevidencefrombasicandclinicalstudies AT smiliauskas respiratorymicrobiomeevidencefrombasicandclinicalstudies AT mzemaitis respiratorymicrobiomeevidencefrombasicandclinicalstudies |