Creatine Supplementation and Brain Health
There is a robust and compelling body of evidence supporting the ergogenic and therapeutic role of creatine supplementation in muscle. Beyond these well-described effects and mechanisms, there is literature to suggest that creatine may also be beneficial to brain health (e.g., cognitive processing,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/13/2/586 |
| _version_ | 1797411629233602560 |
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| author | Hamilton Roschel Bruno Gualano Sergej M. Ostojic Eric S. Rawson |
| author_facet | Hamilton Roschel Bruno Gualano Sergej M. Ostojic Eric S. Rawson |
| author_sort | Hamilton Roschel |
| collection | DOAJ |
| description | There is a robust and compelling body of evidence supporting the ergogenic and therapeutic role of creatine supplementation in muscle. Beyond these well-described effects and mechanisms, there is literature to suggest that creatine may also be beneficial to brain health (e.g., cognitive processing, brain function, and recovery from trauma). This is a growing field of research, and the purpose of this short review is to provide an update on the effects of creatine supplementation on brain health in humans. There is a potential for creatine supplementation to improve cognitive processing, especially in conditions characterized by brain creatine deficits, which could be induced by acute stressors (e.g., exercise, sleep deprivation) or chronic, pathologic conditions (e.g., creatine synthesis enzyme deficiencies, mild traumatic brain injury, aging, Alzheimer’s disease, depression). Despite this, the optimal creatine protocol able to increase brain creatine levels is still to be determined. Similarly, supplementation studies concomitantly assessing brain creatine and cognitive function are needed. Collectively, data available are promising and future research in the area is warranted. |
| first_indexed | 2024-03-09T04:48:54Z |
| format | Article |
| id | doaj.art-74477090eceb4b4588f7e0696a04a5d1 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T04:48:54Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-74477090eceb4b4588f7e0696a04a5d12023-12-03T13:12:12ZengMDPI AGNutrients2072-66432021-02-0113258610.3390/nu13020586Creatine Supplementation and Brain HealthHamilton Roschel0Bruno Gualano1Sergej M. Ostojic2Eric S. Rawson3Applied Physiology & Nutrition Research Group, Rheumatology Division, School of Physical Education and Sport, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 01246-903, BrazilApplied Physiology & Nutrition Research Group, Rheumatology Division, School of Physical Education and Sport, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 01246-903, BrazilFSPE Applied Bioenergetics Lab, University of Novi Sad, 21000 Novi Sad, SerbiaDepartment of Health, Nutrition, and Exercise Science, Messiah University, Mechanicsburg, PA 17055, USAThere is a robust and compelling body of evidence supporting the ergogenic and therapeutic role of creatine supplementation in muscle. Beyond these well-described effects and mechanisms, there is literature to suggest that creatine may also be beneficial to brain health (e.g., cognitive processing, brain function, and recovery from trauma). This is a growing field of research, and the purpose of this short review is to provide an update on the effects of creatine supplementation on brain health in humans. There is a potential for creatine supplementation to improve cognitive processing, especially in conditions characterized by brain creatine deficits, which could be induced by acute stressors (e.g., exercise, sleep deprivation) or chronic, pathologic conditions (e.g., creatine synthesis enzyme deficiencies, mild traumatic brain injury, aging, Alzheimer’s disease, depression). Despite this, the optimal creatine protocol able to increase brain creatine levels is still to be determined. Similarly, supplementation studies concomitantly assessing brain creatine and cognitive function are needed. Collectively, data available are promising and future research in the area is warranted.https://www.mdpi.com/2072-6643/13/2/586phosphorylcreatinedietary supplementcognitionbrain injuryconcussion |
| spellingShingle | Hamilton Roschel Bruno Gualano Sergej M. Ostojic Eric S. Rawson Creatine Supplementation and Brain Health Nutrients phosphorylcreatine dietary supplement cognition brain injury concussion |
| title | Creatine Supplementation and Brain Health |
| title_full | Creatine Supplementation and Brain Health |
| title_fullStr | Creatine Supplementation and Brain Health |
| title_full_unstemmed | Creatine Supplementation and Brain Health |
| title_short | Creatine Supplementation and Brain Health |
| title_sort | creatine supplementation and brain health |
| topic | phosphorylcreatine dietary supplement cognition brain injury concussion |
| url | https://www.mdpi.com/2072-6643/13/2/586 |
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