FTIR and Raman Characterization of TiO2 Nanoparticles Coated with Polyethylene Glycol as Carrier for 2-Methoxyestradiol
The aim of this study was to prepare a novel targeting drug delivery system for 2-Methoxyestradiol (2ME) in order to improve the clinical application of this antitumor drug. It is based in nanoparticles (NPs) of titanium dioxide (TiO2) coated with polyethylene glycol (PEG) and loaded with 2ME. A com...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2017-01-01
|
| Series: | Applied Sciences |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2076-3417/7/1/49 |
| _version_ | 1819104677391761408 |
|---|---|
| author | Andrea León Patricia Reuquen Carolina Garín Rodrigo Segura Patricio Vargas Paula Zapata Pedro A. Orihuela |
| author_facet | Andrea León Patricia Reuquen Carolina Garín Rodrigo Segura Patricio Vargas Paula Zapata Pedro A. Orihuela |
| author_sort | Andrea León |
| collection | DOAJ |
| description | The aim of this study was to prepare a novel targeting drug delivery system for 2-Methoxyestradiol (2ME) in order to improve the clinical application of this antitumor drug. It is based in nanoparticles (NPs) of titanium dioxide (TiO2) coated with polyethylene glycol (PEG) and loaded with 2ME. A complete IR and Raman characterization have been made to confirm the formation of TiO2–PEG–2ME composite. Vibrational modes have been assigned for TiO2, PEG, and 2ME and functionalized TiO2–PEG and TiO2–PEG–2ME. The observed variation in peak position of FTIR and Raman of each for these composites has been elucidated in terms of intermolecular interactions between PEG–2ME and TiO2, obtaining step-by-step the modification processes that were attributed to the conjugation of PEG and 2ME to TiO2 NPs. Modifying TiO2 NPs with PEG loaded with the 2ME drug revealed that the titanium dioxide nanocarrier possesses an effective adsorption capability, and we discuss their potential application as a system of drug delivery. |
| first_indexed | 2024-12-22T02:10:09Z |
| format | Article |
| id | doaj.art-7447c93bbddc4ffab170dff9bd03eca5 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-12-22T02:10:09Z |
| publishDate | 2017-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-7447c93bbddc4ffab170dff9bd03eca52022-12-21T18:42:24ZengMDPI AGApplied Sciences2076-34172017-01-01714910.3390/app7010049app7010049FTIR and Raman Characterization of TiO2 Nanoparticles Coated with Polyethylene Glycol as Carrier for 2-MethoxyestradiolAndrea León0Patricia Reuquen1Carolina Garín2Rodrigo Segura3Patricio Vargas4Paula Zapata5Pedro A. Orihuela6Departamento de Física, Universidad Técnica Federico Santa María, Valparaíso 2340000, ChileCentro del Desarrollo para la Nanociencia y Nanotecnología-CEDENNA, Universidad de Santiago de Chile, Santiago 8320000, ChileDepartamento de Física, Universidad Técnica Federico Santa María, Valparaíso 2340000, ChileInstituto de Quimica y Bioquímica, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2340000, ChileDepartamento de Física, Universidad Técnica Federico Santa María, Valparaíso 2340000, ChileGrupo Polímeros, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 8320000, ChileCentro del Desarrollo para la Nanociencia y Nanotecnología-CEDENNA, Universidad de Santiago de Chile, Santiago 8320000, ChileThe aim of this study was to prepare a novel targeting drug delivery system for 2-Methoxyestradiol (2ME) in order to improve the clinical application of this antitumor drug. It is based in nanoparticles (NPs) of titanium dioxide (TiO2) coated with polyethylene glycol (PEG) and loaded with 2ME. A complete IR and Raman characterization have been made to confirm the formation of TiO2–PEG–2ME composite. Vibrational modes have been assigned for TiO2, PEG, and 2ME and functionalized TiO2–PEG and TiO2–PEG–2ME. The observed variation in peak position of FTIR and Raman of each for these composites has been elucidated in terms of intermolecular interactions between PEG–2ME and TiO2, obtaining step-by-step the modification processes that were attributed to the conjugation of PEG and 2ME to TiO2 NPs. Modifying TiO2 NPs with PEG loaded with the 2ME drug revealed that the titanium dioxide nanocarrier possesses an effective adsorption capability, and we discuss their potential application as a system of drug delivery.http://www.mdpi.com/2076-3417/7/1/49TiO2 NPsdrug delivery2-Methoxyestradiolanticancer drugTiO2-2ME NPs |
| spellingShingle | Andrea León Patricia Reuquen Carolina Garín Rodrigo Segura Patricio Vargas Paula Zapata Pedro A. Orihuela FTIR and Raman Characterization of TiO2 Nanoparticles Coated with Polyethylene Glycol as Carrier for 2-Methoxyestradiol Applied Sciences TiO2 NPs drug delivery 2-Methoxyestradiol anticancer drug TiO2-2ME NPs |
| title | FTIR and Raman Characterization of TiO2 Nanoparticles Coated with Polyethylene Glycol as Carrier for 2-Methoxyestradiol |
| title_full | FTIR and Raman Characterization of TiO2 Nanoparticles Coated with Polyethylene Glycol as Carrier for 2-Methoxyestradiol |
| title_fullStr | FTIR and Raman Characterization of TiO2 Nanoparticles Coated with Polyethylene Glycol as Carrier for 2-Methoxyestradiol |
| title_full_unstemmed | FTIR and Raman Characterization of TiO2 Nanoparticles Coated with Polyethylene Glycol as Carrier for 2-Methoxyestradiol |
| title_short | FTIR and Raman Characterization of TiO2 Nanoparticles Coated with Polyethylene Glycol as Carrier for 2-Methoxyestradiol |
| title_sort | ftir and raman characterization of tio2 nanoparticles coated with polyethylene glycol as carrier for 2 methoxyestradiol |
| topic | TiO2 NPs drug delivery 2-Methoxyestradiol anticancer drug TiO2-2ME NPs |
| url | http://www.mdpi.com/2076-3417/7/1/49 |
| work_keys_str_mv | AT andrealeon ftirandramancharacterizationoftio2nanoparticlescoatedwithpolyethyleneglycolascarrierfor2methoxyestradiol AT patriciareuquen ftirandramancharacterizationoftio2nanoparticlescoatedwithpolyethyleneglycolascarrierfor2methoxyestradiol AT carolinagarin ftirandramancharacterizationoftio2nanoparticlescoatedwithpolyethyleneglycolascarrierfor2methoxyestradiol AT rodrigosegura ftirandramancharacterizationoftio2nanoparticlescoatedwithpolyethyleneglycolascarrierfor2methoxyestradiol AT patriciovargas ftirandramancharacterizationoftio2nanoparticlescoatedwithpolyethyleneglycolascarrierfor2methoxyestradiol AT paulazapata ftirandramancharacterizationoftio2nanoparticlescoatedwithpolyethyleneglycolascarrierfor2methoxyestradiol AT pedroaorihuela ftirandramancharacterizationoftio2nanoparticlescoatedwithpolyethyleneglycolascarrierfor2methoxyestradiol |