Study of microbial factors in exacerbation of chronic rhinosinusitis with nasal polyps
Introduction. Chronic rhinosinusitis with nasal polyps (CRSwNP) is considered a multifactorial disease. There are data on the contribution of fungi and viruses to the initiation and development of the inflammatory process, data on the effect of superantigens, biofilms and microbiota on the growth of...
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| Format: | Article |
| Language: | Russian |
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Central Research Institute for Epidemiology
2022-09-01
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| Series: | Журнал микробиологии, эпидемиологии и иммунобиологии |
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| Online Access: | https://microbiol.crie.ru/jour/article/viewFile/1313/759 |
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| author | Elena L. Savlevich Victor I. Egorov Elizaveta Yu. Savushkina Alexander V. Zurochka Andrey N. Gerasimov Elizaveta S. Mitrofanova Elena V. Lyubimova |
| author_facet | Elena L. Savlevich Victor I. Egorov Elizaveta Yu. Savushkina Alexander V. Zurochka Andrey N. Gerasimov Elizaveta S. Mitrofanova Elena V. Lyubimova |
| author_sort | Elena L. Savlevich |
| collection | DOAJ |
| description | Introduction. Chronic rhinosinusitis with nasal polyps (CRSwNP) is considered a multifactorial disease. There are data on the contribution of fungi and viruses to the initiation and development of the inflammatory process, data on the effect of superantigens, biofilms and microbiota on the growth of polyps in the paranasal sinuses. Exacerbation of the disease in patients with CRSwNP leads to a significant decrease in the quality of life.
Aim. To study the bacterial component of the microbiota of nasal and paranasal mucosa in patients with CRSwNP during remission and exacerbation.
Materials and methods. 83 patients with CRSwNP were examined (44 patients in remission, 39 people in the period of exacerbation of the disease). A qualitative and quantitative analysis of bacterial component of the microbiota in all patients were carried out.
Results. No significant differences in the qualitative and quantitative composition of the nasal cavity microbiota during exacerbation and remission of inflammatory process were observed, as well as before and after treatment of the CRSwNP exacerbation. The quantitative assessment of the identified microorganisms in the vast majority of cases was within the normal range. |
| first_indexed | 2024-03-11T10:51:04Z |
| format | Article |
| id | doaj.art-74496048a3b3400480babd666933330b |
| institution | Directory Open Access Journal |
| issn | 0372-9311 2686-7613 |
| language | Russian |
| last_indexed | 2024-03-11T10:51:04Z |
| publishDate | 2022-09-01 |
| publisher | Central Research Institute for Epidemiology |
| record_format | Article |
| series | Журнал микробиологии, эпидемиологии и иммунобиологии |
| spelling | doaj.art-74496048a3b3400480babd666933330b2023-11-13T17:19:43ZrusCentral Research Institute for EpidemiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-76132022-09-0199444545210.36233/0372-9311-201831Study of microbial factors in exacerbation of chronic rhinosinusitis with nasal polypsElena L. Savlevich0https://orcid.org/0000-0003-4031-308XVictor I. Egorov1https://orcid.org/0000-0002-8825-5096Elizaveta Yu. Savushkina2https://orcid.org/0000-0002-9681-1304Alexander V. Zurochka3https://orcid.org/0000-0003-4371-4161Andrey N. Gerasimov4https://orcid.org/0000-0003-4549-7172Elizaveta S. Mitrofanova5https://orcid.org/0000-0003-3379-8699Elena V. Lyubimova6https://orcid.org/0000-0001-9167-2053Central State Medical AcademyM.F. Vladimirsky Moscow Regional Research Clinical InstituteM.F. Vladimirsky Moscow Regional Research Clinical InstituteInstitute of Immunology and PhysiologyI.M. Sechenov First Moscow State Medical University (Sechenov University)Federal Research and Clinical CenterLLC «LOR clinic»Introduction. Chronic rhinosinusitis with nasal polyps (CRSwNP) is considered a multifactorial disease. There are data on the contribution of fungi and viruses to the initiation and development of the inflammatory process, data on the effect of superantigens, biofilms and microbiota on the growth of polyps in the paranasal sinuses. Exacerbation of the disease in patients with CRSwNP leads to a significant decrease in the quality of life. Aim. To study the bacterial component of the microbiota of nasal and paranasal mucosa in patients with CRSwNP during remission and exacerbation. Materials and methods. 83 patients with CRSwNP were examined (44 patients in remission, 39 people in the period of exacerbation of the disease). A qualitative and quantitative analysis of bacterial component of the microbiota in all patients were carried out. Results. No significant differences in the qualitative and quantitative composition of the nasal cavity microbiota during exacerbation and remission of inflammatory process were observed, as well as before and after treatment of the CRSwNP exacerbation. The quantitative assessment of the identified microorganisms in the vast majority of cases was within the normal range.https://microbiol.crie.ru/jour/article/viewFile/1313/759chronic rhinosinusitis with nasal polyps (crswnp)exacerbation of chronic rhinosinusitisstaphylococcus aureusmicrobiota |
| spellingShingle | Elena L. Savlevich Victor I. Egorov Elizaveta Yu. Savushkina Alexander V. Zurochka Andrey N. Gerasimov Elizaveta S. Mitrofanova Elena V. Lyubimova Study of microbial factors in exacerbation of chronic rhinosinusitis with nasal polyps Журнал микробиологии, эпидемиологии и иммунобиологии chronic rhinosinusitis with nasal polyps (crswnp) exacerbation of chronic rhinosinusitis staphylococcus aureus microbiota |
| title | Study of microbial factors in exacerbation of chronic rhinosinusitis with nasal polyps |
| title_full | Study of microbial factors in exacerbation of chronic rhinosinusitis with nasal polyps |
| title_fullStr | Study of microbial factors in exacerbation of chronic rhinosinusitis with nasal polyps |
| title_full_unstemmed | Study of microbial factors in exacerbation of chronic rhinosinusitis with nasal polyps |
| title_short | Study of microbial factors in exacerbation of chronic rhinosinusitis with nasal polyps |
| title_sort | study of microbial factors in exacerbation of chronic rhinosinusitis with nasal polyps |
| topic | chronic rhinosinusitis with nasal polyps (crswnp) exacerbation of chronic rhinosinusitis staphylococcus aureus microbiota |
| url | https://microbiol.crie.ru/jour/article/viewFile/1313/759 |
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