Change of Gut Microbiota in PRRSV-Resistant Pigs and PRRSV-Susceptible Pigs from Tongcheng Pigs and Large White Pigs Crossed Population upon PRRSV Infection
Porcine Reproductive and Respiratory Syndrome (PRRS) is one of the serious infectious diseases that threatens the swine industry. Increasing evidence shows that gut microbiota plays an important role in regulating host immune responses to PRRS virus (PRRSV). The aim of this study was to investigate...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Animals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2615/12/12/1504 |
| _version_ | 1797490742845767680 |
|---|---|
| author | Tengfei Wang Kaifeng Guan Qiuju Su Xiaotong Wang Zengqiang Yan Kailin Kuang Yuan Wang Qingde Zhang Xiang Zhou Bang Liu |
| author_facet | Tengfei Wang Kaifeng Guan Qiuju Su Xiaotong Wang Zengqiang Yan Kailin Kuang Yuan Wang Qingde Zhang Xiang Zhou Bang Liu |
| author_sort | Tengfei Wang |
| collection | DOAJ |
| description | Porcine Reproductive and Respiratory Syndrome (PRRS) is one of the serious infectious diseases that threatens the swine industry. Increasing evidence shows that gut microbiota plays an important role in regulating host immune responses to PRRS virus (PRRSV). The aim of this study was to investigate gut microbiota difference between PRRSV-resistant pigs and PRRSV-suspectable pigs derived from a Tongcheng pigs and Large White pigs crossed population. PRRSV infection induces an increase in the abundance and diversity of gut microbiota. Correlation analysis showed that 36 genera were correlated with viral loads or weight gain after PRRSV infection. <i>Prevotellaceae-NK3B31-group</i>, <i>Christensenellaceae-R7-group</i>, and <i>Parabacteroides</i> were highly correlated with both viral load and weight gain. Notably, the diversity and abundance of beneficial bacteria such as <i>Prevotellaceae-NK3B31-group</i> was high in resistant pigs, and the diversity and abundance of pathogenic bacteria such as <i>Campylobacter</i> and <i>Desulfovibrio</i> were high in susceptible pigs. Gut microbiota were significantly associated with immune function and growth performance, suggesting that these genera might be related to viremia, clinical symptoms, and disease resistance. Altogether, this study revealed the correlation of gut microbiota with PRRSV infection and gut microbiota interventions may provide an effective prevention against PRRSV infection. |
| first_indexed | 2024-03-10T00:37:21Z |
| format | Article |
| id | doaj.art-74499d6cfa664c30b766554a76db6d6f |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T00:37:21Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-74499d6cfa664c30b766554a76db6d6f2023-11-23T15:14:12ZengMDPI AGAnimals2076-26152022-06-011212150410.3390/ani12121504Change of Gut Microbiota in PRRSV-Resistant Pigs and PRRSV-Susceptible Pigs from Tongcheng Pigs and Large White Pigs Crossed Population upon PRRSV InfectionTengfei Wang0Kaifeng Guan1Qiuju Su2Xiaotong Wang3Zengqiang Yan4Kailin Kuang5Yuan Wang6Qingde Zhang7Xiang Zhou8Bang Liu9Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, ChinaKey Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, ChinaKey Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, ChinaKey Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, ChinaKey Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, ChinaKey Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, ChinaKey Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, ChinaLaboratory Animal Centre, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, ChinaKey Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, ChinaKey Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, ChinaPorcine Reproductive and Respiratory Syndrome (PRRS) is one of the serious infectious diseases that threatens the swine industry. Increasing evidence shows that gut microbiota plays an important role in regulating host immune responses to PRRS virus (PRRSV). The aim of this study was to investigate gut microbiota difference between PRRSV-resistant pigs and PRRSV-suspectable pigs derived from a Tongcheng pigs and Large White pigs crossed population. PRRSV infection induces an increase in the abundance and diversity of gut microbiota. Correlation analysis showed that 36 genera were correlated with viral loads or weight gain after PRRSV infection. <i>Prevotellaceae-NK3B31-group</i>, <i>Christensenellaceae-R7-group</i>, and <i>Parabacteroides</i> were highly correlated with both viral load and weight gain. Notably, the diversity and abundance of beneficial bacteria such as <i>Prevotellaceae-NK3B31-group</i> was high in resistant pigs, and the diversity and abundance of pathogenic bacteria such as <i>Campylobacter</i> and <i>Desulfovibrio</i> were high in susceptible pigs. Gut microbiota were significantly associated with immune function and growth performance, suggesting that these genera might be related to viremia, clinical symptoms, and disease resistance. Altogether, this study revealed the correlation of gut microbiota with PRRSV infection and gut microbiota interventions may provide an effective prevention against PRRSV infection.https://www.mdpi.com/2076-2615/12/12/1504PRRSV16S RNAgut microbiotaresistant pigssusceptible pigs |
| spellingShingle | Tengfei Wang Kaifeng Guan Qiuju Su Xiaotong Wang Zengqiang Yan Kailin Kuang Yuan Wang Qingde Zhang Xiang Zhou Bang Liu Change of Gut Microbiota in PRRSV-Resistant Pigs and PRRSV-Susceptible Pigs from Tongcheng Pigs and Large White Pigs Crossed Population upon PRRSV Infection Animals PRRSV 16S RNA gut microbiota resistant pigs susceptible pigs |
| title | Change of Gut Microbiota in PRRSV-Resistant Pigs and PRRSV-Susceptible Pigs from Tongcheng Pigs and Large White Pigs Crossed Population upon PRRSV Infection |
| title_full | Change of Gut Microbiota in PRRSV-Resistant Pigs and PRRSV-Susceptible Pigs from Tongcheng Pigs and Large White Pigs Crossed Population upon PRRSV Infection |
| title_fullStr | Change of Gut Microbiota in PRRSV-Resistant Pigs and PRRSV-Susceptible Pigs from Tongcheng Pigs and Large White Pigs Crossed Population upon PRRSV Infection |
| title_full_unstemmed | Change of Gut Microbiota in PRRSV-Resistant Pigs and PRRSV-Susceptible Pigs from Tongcheng Pigs and Large White Pigs Crossed Population upon PRRSV Infection |
| title_short | Change of Gut Microbiota in PRRSV-Resistant Pigs and PRRSV-Susceptible Pigs from Tongcheng Pigs and Large White Pigs Crossed Population upon PRRSV Infection |
| title_sort | change of gut microbiota in prrsv resistant pigs and prrsv susceptible pigs from tongcheng pigs and large white pigs crossed population upon prrsv infection |
| topic | PRRSV 16S RNA gut microbiota resistant pigs susceptible pigs |
| url | https://www.mdpi.com/2076-2615/12/12/1504 |
| work_keys_str_mv | AT tengfeiwang changeofgutmicrobiotainprrsvresistantpigsandprrsvsusceptiblepigsfromtongchengpigsandlargewhitepigscrossedpopulationuponprrsvinfection AT kaifengguan changeofgutmicrobiotainprrsvresistantpigsandprrsvsusceptiblepigsfromtongchengpigsandlargewhitepigscrossedpopulationuponprrsvinfection AT qiujusu changeofgutmicrobiotainprrsvresistantpigsandprrsvsusceptiblepigsfromtongchengpigsandlargewhitepigscrossedpopulationuponprrsvinfection AT xiaotongwang changeofgutmicrobiotainprrsvresistantpigsandprrsvsusceptiblepigsfromtongchengpigsandlargewhitepigscrossedpopulationuponprrsvinfection AT zengqiangyan changeofgutmicrobiotainprrsvresistantpigsandprrsvsusceptiblepigsfromtongchengpigsandlargewhitepigscrossedpopulationuponprrsvinfection AT kailinkuang changeofgutmicrobiotainprrsvresistantpigsandprrsvsusceptiblepigsfromtongchengpigsandlargewhitepigscrossedpopulationuponprrsvinfection AT yuanwang changeofgutmicrobiotainprrsvresistantpigsandprrsvsusceptiblepigsfromtongchengpigsandlargewhitepigscrossedpopulationuponprrsvinfection AT qingdezhang changeofgutmicrobiotainprrsvresistantpigsandprrsvsusceptiblepigsfromtongchengpigsandlargewhitepigscrossedpopulationuponprrsvinfection AT xiangzhou changeofgutmicrobiotainprrsvresistantpigsandprrsvsusceptiblepigsfromtongchengpigsandlargewhitepigscrossedpopulationuponprrsvinfection AT bangliu changeofgutmicrobiotainprrsvresistantpigsandprrsvsusceptiblepigsfromtongchengpigsandlargewhitepigscrossedpopulationuponprrsvinfection |