Excitation of medium spiny neurons by ‘inhibitory’ ultrapotent chemogenetics via shifts in chloride reversal potential

Excitation of medium spiny neurons by ‘inhibitory’ ultrapotent chemogenetics via shifts in chloride reversal potential

Ultrapotent chemogenetics, including the chloride-permeable inhibitory PSAM4-GlyR receptor, were recently proposed as a powerful strategy to selectively control neuronal activity in awake, behaving animals. We aimed to validate the inhibitory function of PSAM4-GlyR in dopamine D1 receptor-expressing...

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Bibliographic Details
Main Authors: Stephanie C Gantz, Maria M Ortiz, Andrew J Belilos, Khaled Moussawi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
chemogenetics
PSAM
uPSEM
D1 medium spiny neuron
chloride permeability
Online Access:https://elifesciences.org/articles/64241

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