Altered resting-state functional connectivity of insula in children with primary nocturnal enuresis
ObjectivePrimary nocturnal enuresis (PNE) is a common developmental condition in school-aged children. The objective is to better understand the pathophysiology of PNE by using insula-centered resting-state functional connectivity (rsFC).MethodsWe recruited 66 right-handed participants in our analys...
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.913489/full |
| _version_ | 1811218393484754944 |
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| author | Shaogen Zhong Jiayao Shen Mengxing Wang Yi Mao Xiaoxia Du Jun Ma |
| author_facet | Shaogen Zhong Jiayao Shen Mengxing Wang Yi Mao Xiaoxia Du Jun Ma |
| author_sort | Shaogen Zhong |
| collection | DOAJ |
| description | ObjectivePrimary nocturnal enuresis (PNE) is a common developmental condition in school-aged children. The objective is to better understand the pathophysiology of PNE by using insula-centered resting-state functional connectivity (rsFC).MethodsWe recruited 66 right-handed participants in our analysis, 33 with PNE and 33 healthy control (HC) children without enuresis matched for gender and age. Functional and structural MRI data were obtained from all the children. Seed-based rsFC was used to examine differences in insular functional connectivity between the PNE and HC groups. Correlation analyses were carried out to explore the relationship between abnormal insula-centered functional connectivity and clinical characteristics in the PNE group.ResultsCompared with HC children, the children with PNE demonstrated decreased left and right insular rsFC with the right medial superior frontal gyrus (SFG). In addition, the bilateral dorsal anterior insula (dAI) seeds also indicated the reduced rsFC with right medial SFG. Furthermore, the right posterior insula (PI) seed showed the weaker rsFC with the right medial SFG, while the left PI seed displayed the weaker rsFC with the right SFG. No statistically significant correlations were detected between aberrant insular rsFC and clinical variables (e.g., micturition desire awakening, bed-wetting frequency, and bladder volume) in results without global signal regression (GSR) in the PNE group. However, before and after setting age as a covariate, significant and positive correlations between bladder volume and the rsFC of the left dAI with right medial SFG and the rsFC of the right PI with right medial SFG were found in results with GSR in the PNE group.ConclusionTo the best of our knowledge, this study explored the rsFC patterns of the insula in children with PNE for the first time. These results uncovered the abnormal rsFC of the insula with the medial prefrontal cortex without and with GSR in the PNE group, suggesting that dysconnectivity of the salience network (SN)-default mode network (DMN) may involve in the underlying pathophysiology of children with PNE. However, the inconsistent associations between bladder volume and dysconnectivity of the SN-DMN in results without and with GSR need further studies. |
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| language | English |
| last_indexed | 2024-04-12T07:09:37Z |
| publishDate | 2022-07-01 |
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| spelling | doaj.art-7449b0561ffe4925839f6fc5e79ad9c42022-12-22T03:42:41ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-07-011610.3389/fnins.2022.913489913489Altered resting-state functional connectivity of insula in children with primary nocturnal enuresisShaogen Zhong0Jiayao Shen1Mengxing Wang2Yi Mao3Xiaoxia Du4Jun Ma5Department of Developmental and Behavioral Pediatrics, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Nephrology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaCollege of Medical Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, ChinaDepartment of Developmental and Behavioral Pediatrics, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaSchool of Psychology, Shanghai University of Sport, Shanghai, ChinaDepartment of Developmental and Behavioral Pediatrics, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaObjectivePrimary nocturnal enuresis (PNE) is a common developmental condition in school-aged children. The objective is to better understand the pathophysiology of PNE by using insula-centered resting-state functional connectivity (rsFC).MethodsWe recruited 66 right-handed participants in our analysis, 33 with PNE and 33 healthy control (HC) children without enuresis matched for gender and age. Functional and structural MRI data were obtained from all the children. Seed-based rsFC was used to examine differences in insular functional connectivity between the PNE and HC groups. Correlation analyses were carried out to explore the relationship between abnormal insula-centered functional connectivity and clinical characteristics in the PNE group.ResultsCompared with HC children, the children with PNE demonstrated decreased left and right insular rsFC with the right medial superior frontal gyrus (SFG). In addition, the bilateral dorsal anterior insula (dAI) seeds also indicated the reduced rsFC with right medial SFG. Furthermore, the right posterior insula (PI) seed showed the weaker rsFC with the right medial SFG, while the left PI seed displayed the weaker rsFC with the right SFG. No statistically significant correlations were detected between aberrant insular rsFC and clinical variables (e.g., micturition desire awakening, bed-wetting frequency, and bladder volume) in results without global signal regression (GSR) in the PNE group. However, before and after setting age as a covariate, significant and positive correlations between bladder volume and the rsFC of the left dAI with right medial SFG and the rsFC of the right PI with right medial SFG were found in results with GSR in the PNE group.ConclusionTo the best of our knowledge, this study explored the rsFC patterns of the insula in children with PNE for the first time. These results uncovered the abnormal rsFC of the insula with the medial prefrontal cortex without and with GSR in the PNE group, suggesting that dysconnectivity of the salience network (SN)-default mode network (DMN) may involve in the underlying pathophysiology of children with PNE. However, the inconsistent associations between bladder volume and dysconnectivity of the SN-DMN in results without and with GSR need further studies.https://www.frontiersin.org/articles/10.3389/fnins.2022.913489/fullarousalfunctional connectivityinsulaprefrontal cortexprimary nocturnal enuresis |
| spellingShingle | Shaogen Zhong Jiayao Shen Mengxing Wang Yi Mao Xiaoxia Du Jun Ma Altered resting-state functional connectivity of insula in children with primary nocturnal enuresis Frontiers in Neuroscience arousal functional connectivity insula prefrontal cortex primary nocturnal enuresis |
| title | Altered resting-state functional connectivity of insula in children with primary nocturnal enuresis |
| title_full | Altered resting-state functional connectivity of insula in children with primary nocturnal enuresis |
| title_fullStr | Altered resting-state functional connectivity of insula in children with primary nocturnal enuresis |
| title_full_unstemmed | Altered resting-state functional connectivity of insula in children with primary nocturnal enuresis |
| title_short | Altered resting-state functional connectivity of insula in children with primary nocturnal enuresis |
| title_sort | altered resting state functional connectivity of insula in children with primary nocturnal enuresis |
| topic | arousal functional connectivity insula prefrontal cortex primary nocturnal enuresis |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.913489/full |
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