Gut Microbiota Co-microevolution with Selection for Host Humoral Immunity
To explore coevolution between the gut microbiota and the humoral immune system of the host, we used chickens as the model organism. The host populations were two lines (HAS and LAS) developed from a common founder that had undergone 40 generations of divergent selection for antibody titers to sheep...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-07-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fmicb.2017.01243/full |
| _version_ | 1811264335311273984 |
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| author | Lingyu Yang Shuyun Liu Jinmei Ding Ronghua Dai Chuan He Ke Xu Christa F. Honaker Yan Zhang Paul Siegel He Meng |
| author_facet | Lingyu Yang Shuyun Liu Jinmei Ding Ronghua Dai Chuan He Ke Xu Christa F. Honaker Yan Zhang Paul Siegel He Meng |
| author_sort | Lingyu Yang |
| collection | DOAJ |
| description | To explore coevolution between the gut microbiota and the humoral immune system of the host, we used chickens as the model organism. The host populations were two lines (HAS and LAS) developed from a common founder that had undergone 40 generations of divergent selection for antibody titers to sheep red blood cells (SRBC) and two relaxed sublines (HAR and LAR). Analysis revealed that microevolution of host humoral immunity contributed to the composition of gut microbiota at the taxa level. Relaxing selection enriched some microorganisms whose functions were opposite to host immunity. Particularly, Ruminococcaceae and Oscillospira enriched in high antibody relaxed (HAR) and contributed to reduction in antibody response, while Lactobacillus increased in low antibody relaxed (LAR) and elevated the antibody response. Microbial functional analysis showed that alterations were involved in pathways relating to the immune system and infectious diseases. Our findings demonstrated co-microevolution relationships of host-microbiota and that gut microorganisms influenced host immunity. |
| first_indexed | 2024-04-12T20:02:22Z |
| format | Article |
| id | doaj.art-7449d4e2da014c9fb0a3aca2bd00b28a |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-12T20:02:22Z |
| publishDate | 2017-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-7449d4e2da014c9fb0a3aca2bd00b28a2022-12-22T03:18:30ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2017-07-01810.3389/fmicb.2017.01243269423Gut Microbiota Co-microevolution with Selection for Host Humoral ImmunityLingyu Yang0Shuyun Liu1Jinmei Ding2Ronghua Dai3Chuan He4Ke Xu5Christa F. Honaker6Yan Zhang7Paul Siegel8He Meng9Shanghai Key Laboratory of Veterinary Biotechnology, Department of Animal Science, School of Agriculture and Biology, Shanghai Jiao Tong UniversityShanghai, ChinaShanghai Key Laboratory of Veterinary Biotechnology, Department of Animal Science, School of Agriculture and Biology, Shanghai Jiao Tong UniversityShanghai, ChinaShanghai Key Laboratory of Veterinary Biotechnology, Department of Animal Science, School of Agriculture and Biology, Shanghai Jiao Tong UniversityShanghai, ChinaShanghai Key Laboratory of Veterinary Biotechnology, Department of Animal Science, School of Agriculture and Biology, Shanghai Jiao Tong UniversityShanghai, ChinaShanghai Key Laboratory of Veterinary Biotechnology, Department of Animal Science, School of Agriculture and Biology, Shanghai Jiao Tong UniversityShanghai, ChinaShanghai Key Laboratory of Veterinary Biotechnology, Department of Animal Science, School of Agriculture and Biology, Shanghai Jiao Tong UniversityShanghai, ChinaDepartment of Animal and Poultry Sciences, Virginia TechBlacksburg, VA, United StatesCarilion ClinicRoanoke, VA, United StatesDepartment of Animal and Poultry Sciences, Virginia TechBlacksburg, VA, United StatesShanghai Key Laboratory of Veterinary Biotechnology, Department of Animal Science, School of Agriculture and Biology, Shanghai Jiao Tong UniversityShanghai, ChinaTo explore coevolution between the gut microbiota and the humoral immune system of the host, we used chickens as the model organism. The host populations were two lines (HAS and LAS) developed from a common founder that had undergone 40 generations of divergent selection for antibody titers to sheep red blood cells (SRBC) and two relaxed sublines (HAR and LAR). Analysis revealed that microevolution of host humoral immunity contributed to the composition of gut microbiota at the taxa level. Relaxing selection enriched some microorganisms whose functions were opposite to host immunity. Particularly, Ruminococcaceae and Oscillospira enriched in high antibody relaxed (HAR) and contributed to reduction in antibody response, while Lactobacillus increased in low antibody relaxed (LAR) and elevated the antibody response. Microbial functional analysis showed that alterations were involved in pathways relating to the immune system and infectious diseases. Our findings demonstrated co-microevolution relationships of host-microbiota and that gut microorganisms influenced host immunity.http://journal.frontiersin.org/article/10.3389/fmicb.2017.01243/fullhumoral immunitygut microbiotachickenantibody titersco-microevolutionhost-microbe interactions |
| spellingShingle | Lingyu Yang Shuyun Liu Jinmei Ding Ronghua Dai Chuan He Ke Xu Christa F. Honaker Yan Zhang Paul Siegel He Meng Gut Microbiota Co-microevolution with Selection for Host Humoral Immunity Frontiers in Microbiology humoral immunity gut microbiota chicken antibody titers co-microevolution host-microbe interactions |
| title | Gut Microbiota Co-microevolution with Selection for Host Humoral Immunity |
| title_full | Gut Microbiota Co-microevolution with Selection for Host Humoral Immunity |
| title_fullStr | Gut Microbiota Co-microevolution with Selection for Host Humoral Immunity |
| title_full_unstemmed | Gut Microbiota Co-microevolution with Selection for Host Humoral Immunity |
| title_short | Gut Microbiota Co-microevolution with Selection for Host Humoral Immunity |
| title_sort | gut microbiota co microevolution with selection for host humoral immunity |
| topic | humoral immunity gut microbiota chicken antibody titers co-microevolution host-microbe interactions |
| url | http://journal.frontiersin.org/article/10.3389/fmicb.2017.01243/full |
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