Chronic cerebrovascular diseases, metabolic syndrome, and the hemorrheological and hemostatic systems
Aim: to study an association between metabolic syndrome and endothelial dysfunction as a regulator of hemorrheological and hemostatic processes in patients with chronic forms of cerebral circulatory insufficiency. Subjects and methods. Forty-six patients with chronic cerebrovascular diseases (CCVD)...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2010-10-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/30660 |
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| author | Marine Movsesovna Tanashyan Viktoriya Grigor'evna Ionova Sergey Valer'evich Orlov Nadezhda Grigor'evna Omel'chenko Alla Anatol'evna Shabalina Marina Vladimirovna Kostyreva M M Tanashyan V G Ionova S V Orlov N G Omelchenko A A Shabalina M V Kostyreva |
| author_facet | Marine Movsesovna Tanashyan Viktoriya Grigor'evna Ionova Sergey Valer'evich Orlov Nadezhda Grigor'evna Omel'chenko Alla Anatol'evna Shabalina Marina Vladimirovna Kostyreva M M Tanashyan V G Ionova S V Orlov N G Omelchenko A A Shabalina M V Kostyreva |
| author_sort | Marine Movsesovna Tanashyan |
| collection | DOAJ |
| description | Aim: to study an association between metabolic syndrome and endothelial dysfunction as a regulator of hemorrheological and hemostatic processes in patients with chronic forms of cerebral circulatory insufficiency.
Subjects and methods. Forty-six patients with chronic cerebrovascular diseases (CCVD) were examined; of them 23 patients were diagnosed as having metabolic syndrome (MS). Clinical manifestations and major hemorrheological and hemostatic parameters, such as platelet and erythrocyte aggregation, fibrinogen, hematocrit, von Willebrand factor, antithrombin III, intercellular adhesion molecules (IAM), etc., were estimated. Endothelial dysfunction was studied from the data of cuff test (CT).
Results. MS promotes a higher degree of clinical symptomatology in patients with CCVD and more significant impairments in the hemorrheological and hemostatic systems. CT has shown that all the patients have an inadequate endothelial reaction - the antiaggregatory, fibrinolytic, and anticoagulant activities of the endothelium are lowered. There was endothelium-dependent hyperproduction of IAM.
Conclusion. The found changes suggest that MS has a considerable impact on the formation of a significant procoagulant state of the hemorrheological and hemostatic systems in patients with CCVD. |
| first_indexed | 2024-04-12T08:25:21Z |
| format | Article |
| id | doaj.art-7449f20a870d40f6a91e9811930753df |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-04-12T08:25:21Z |
| publishDate | 2010-10-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-7449f20a870d40f6a91e9811930753df2022-12-22T03:40:23Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422010-10-018210192427687Chronic cerebrovascular diseases, metabolic syndrome, and the hemorrheological and hemostatic systemsMarine Movsesovna TanashyanViktoriya Grigor'evna IonovaSergey Valer'evich OrlovNadezhda Grigor'evna Omel'chenkoAlla Anatol'evna ShabalinaMarina Vladimirovna KostyrevaM M TanashyanV G IonovaS V OrlovN G OmelchenkoA A ShabalinaM V KostyrevaAim: to study an association between metabolic syndrome and endothelial dysfunction as a regulator of hemorrheological and hemostatic processes in patients with chronic forms of cerebral circulatory insufficiency. Subjects and methods. Forty-six patients with chronic cerebrovascular diseases (CCVD) were examined; of them 23 patients were diagnosed as having metabolic syndrome (MS). Clinical manifestations and major hemorrheological and hemostatic parameters, such as platelet and erythrocyte aggregation, fibrinogen, hematocrit, von Willebrand factor, antithrombin III, intercellular adhesion molecules (IAM), etc., were estimated. Endothelial dysfunction was studied from the data of cuff test (CT). Results. MS promotes a higher degree of clinical symptomatology in patients with CCVD and more significant impairments in the hemorrheological and hemostatic systems. CT has shown that all the patients have an inadequate endothelial reaction - the antiaggregatory, fibrinolytic, and anticoagulant activities of the endothelium are lowered. There was endothelium-dependent hyperproduction of IAM. Conclusion. The found changes suggest that MS has a considerable impact on the formation of a significant procoagulant state of the hemorrheological and hemostatic systems in patients with CCVD.https://ter-arkhiv.ru/0040-3660/article/view/30660metabolic syndromechronic cerebrovascular diseaseshemorrheologyhemostasisendothelial dysfunction |
| spellingShingle | Marine Movsesovna Tanashyan Viktoriya Grigor'evna Ionova Sergey Valer'evich Orlov Nadezhda Grigor'evna Omel'chenko Alla Anatol'evna Shabalina Marina Vladimirovna Kostyreva M M Tanashyan V G Ionova S V Orlov N G Omelchenko A A Shabalina M V Kostyreva Chronic cerebrovascular diseases, metabolic syndrome, and the hemorrheological and hemostatic systems Терапевтический архив metabolic syndrome chronic cerebrovascular diseases hemorrheology hemostasis endothelial dysfunction |
| title | Chronic cerebrovascular diseases, metabolic syndrome, and the hemorrheological and hemostatic systems |
| title_full | Chronic cerebrovascular diseases, metabolic syndrome, and the hemorrheological and hemostatic systems |
| title_fullStr | Chronic cerebrovascular diseases, metabolic syndrome, and the hemorrheological and hemostatic systems |
| title_full_unstemmed | Chronic cerebrovascular diseases, metabolic syndrome, and the hemorrheological and hemostatic systems |
| title_short | Chronic cerebrovascular diseases, metabolic syndrome, and the hemorrheological and hemostatic systems |
| title_sort | chronic cerebrovascular diseases metabolic syndrome and the hemorrheological and hemostatic systems |
| topic | metabolic syndrome chronic cerebrovascular diseases hemorrheology hemostasis endothelial dysfunction |
| url | https://ter-arkhiv.ru/0040-3660/article/view/30660 |
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