Assessment of the effect of iron-rich humic substances on hematological parameters in the model of acute posthemorrhagic and iron deficiency anemia
Aim. To assess the effect of iron-rich humic substances on hematological parameters in acute post-hemorrhagic and iron deficiency anemia.Materials and methods. Materials for the study were samples of iron-rich active pharmaceutical ingredients based on humic substances (Fe(III) hydroxide complexes w...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2023-01-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/5016 |
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| author | K. A. Bratishko L. A. Logvinova V. V. Ivanov A. M. Zhirkova A. A. Ufandeew E. E. Buyko A. P. Zima E. S. Rabcevich M. V. Kuznecova M. V. Belousov I. V. Perminova M. V. Zykova |
| author_facet | K. A. Bratishko L. A. Logvinova V. V. Ivanov A. M. Zhirkova A. A. Ufandeew E. E. Buyko A. P. Zima E. S. Rabcevich M. V. Kuznecova M. V. Belousov I. V. Perminova M. V. Zykova |
| author_sort | K. A. Bratishko |
| collection | DOAJ |
| description | Aim. To assess the effect of iron-rich humic substances on hematological parameters in acute post-hemorrhagic and iron deficiency anemia.Materials and methods. Materials for the study were samples of iron-rich active pharmaceutical ingredients based on humic substances (Fe(III) hydroxide complexes with humic substances and polymaltose): HA-Fe3+, HA-PMFe3+, FA-Fe3+, and FA-PM-Fe3+. The anti-anemic activity of the substances was studied on 53 female Wistar rats of the conventional rat line in the model of acute posthemorrhagic and iron deficiency anemia. Anti-anemic activity was assessed by the hemoglobin level, erythrocyte count, hematocrit, and serum iron level.Results. The studied substances HA-Fe3+ and FA-Fe3+ are the most effective in correcting the consequences of both experimental acute posthemorrhagic anemia and iron deficiency anemia. Their effect is comparable to that of the positive control drug Ferrum Lek.Conclusion. Fe(III) hydroxide complexes stabilized by humic and fulvic acids exhibit anti-anemic activity. |
| first_indexed | 2024-04-10T01:05:20Z |
| format | Article |
| id | doaj.art-744a53b0af834a2ebf37d18fe5bda308 |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:05:20Z |
| publishDate | 2023-01-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-744a53b0af834a2ebf37d18fe5bda3082023-03-13T09:58:28ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842023-01-01214131910.20538/1682-0363-2022-4-13-192936Assessment of the effect of iron-rich humic substances on hematological parameters in the model of acute posthemorrhagic and iron deficiency anemiaK. A. Bratishko0L. A. Logvinova1V. V. Ivanov2A. M. Zhirkova3A. A. Ufandeew4E. E. Buyko5A. P. Zima6E. S. Rabcevich7M. V. Kuznecova8M. V. Belousov9I. V. Perminova10M. V. Zykova11Сибирский государственный медицинский университет (СибГМУ)Сибирский государственный медицинский университет (СибГМУ)Сибирский государственный медицинский университет (СибГМУ)Московский государственный университет (МГУ) им. М.В. ЛомоносоваСибирский государственный медицинский университет (СибГМУ)Сибирский государственный медицинский университет (СибГМУ)Сибирский государственный медицинский университет (СибГМУ)Сибирский государственный медицинский университет (СибГМУ); Национальный исследовательский Томский государственный университет (НИ ТГУ)Сибирский государственный медицинский университет (СибГМУ)Сибирский государственный медицинский университет (СибГМУ)Московский государственный университет (МГУ) им. М.В. ЛомоносоваСибирский государственный медицинский университет (СибГМУ)Aim. To assess the effect of iron-rich humic substances on hematological parameters in acute post-hemorrhagic and iron deficiency anemia.Materials and methods. Materials for the study were samples of iron-rich active pharmaceutical ingredients based on humic substances (Fe(III) hydroxide complexes with humic substances and polymaltose): HA-Fe3+, HA-PMFe3+, FA-Fe3+, and FA-PM-Fe3+. The anti-anemic activity of the substances was studied on 53 female Wistar rats of the conventional rat line in the model of acute posthemorrhagic and iron deficiency anemia. Anti-anemic activity was assessed by the hemoglobin level, erythrocyte count, hematocrit, and serum iron level.Results. The studied substances HA-Fe3+ and FA-Fe3+ are the most effective in correcting the consequences of both experimental acute posthemorrhagic anemia and iron deficiency anemia. Their effect is comparable to that of the positive control drug Ferrum Lek.Conclusion. Fe(III) hydroxide complexes stabilized by humic and fulvic acids exhibit anti-anemic activity.https://bulletin.ssmu.ru/jour/article/view/5016острая постгеморрагическая анемияжелезодефицитная анемиягуминовые веществалигандыкомплексы гидроксида fe(iii) |
| spellingShingle | K. A. Bratishko L. A. Logvinova V. V. Ivanov A. M. Zhirkova A. A. Ufandeew E. E. Buyko A. P. Zima E. S. Rabcevich M. V. Kuznecova M. V. Belousov I. V. Perminova M. V. Zykova Assessment of the effect of iron-rich humic substances on hematological parameters in the model of acute posthemorrhagic and iron deficiency anemia Бюллетень сибирской медицины острая постгеморрагическая анемия железодефицитная анемия гуминовые вещества лиганды комплексы гидроксида fe(iii) |
| title | Assessment of the effect of iron-rich humic substances on hematological parameters in the model of acute posthemorrhagic and iron deficiency anemia |
| title_full | Assessment of the effect of iron-rich humic substances on hematological parameters in the model of acute posthemorrhagic and iron deficiency anemia |
| title_fullStr | Assessment of the effect of iron-rich humic substances on hematological parameters in the model of acute posthemorrhagic and iron deficiency anemia |
| title_full_unstemmed | Assessment of the effect of iron-rich humic substances on hematological parameters in the model of acute posthemorrhagic and iron deficiency anemia |
| title_short | Assessment of the effect of iron-rich humic substances on hematological parameters in the model of acute posthemorrhagic and iron deficiency anemia |
| title_sort | assessment of the effect of iron rich humic substances on hematological parameters in the model of acute posthemorrhagic and iron deficiency anemia |
| topic | острая постгеморрагическая анемия железодефицитная анемия гуминовые вещества лиганды комплексы гидроксида fe(iii) |
| url | https://bulletin.ssmu.ru/jour/article/view/5016 |
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