Protective Potential of a Botanical-Based Supplement Ingredient against the Impact of Environmental Pollution on Cutaneous and Cardiopulmonary Systems: Preclinical Study
Air pollution is a growing threat to human health. Airborne pollution effects on respiratory, cardiovascular and skin health are well-established. The main mechanisms of air-pollution-induced health effects involve oxidative stress and inflammation. The present study evaluates the potential of a pol...
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| Format: | Article |
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MDPI AG
2024-02-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/46/2/99 |
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| author | Laurent Peno-Mazzarino Nikita Radionov Marián Merino Sonia González José L. Mullor Jonathan Jones Nuria Caturla |
| author_facet | Laurent Peno-Mazzarino Nikita Radionov Marián Merino Sonia González José L. Mullor Jonathan Jones Nuria Caturla |
| author_sort | Laurent Peno-Mazzarino |
| collection | DOAJ |
| description | Air pollution is a growing threat to human health. Airborne pollution effects on respiratory, cardiovascular and skin health are well-established. The main mechanisms of air-pollution-induced health effects involve oxidative stress and inflammation. The present study evaluates the potential of a polyphenol-enriched food supplement ingredient comprising <i>Lippia citriodora</i>, <i>Olea europaea</i>, <i>Rosmarinus officinalis</i>, and <i>Sophora japonica</i> extracts in mitigating the adverse effects of environmental pollution on skin and cardiopulmonary systems. Both in vitro and ex vivo studies were used to assess the blend’s effects against pollution-induced damage. In these studies, the botanical blend was found to reduce lipid peroxidation, inflammation (by reducing IL-1α), and metabolic alterations (by regulating MT-1H, AhR, and Nrf2 expression) in human skin explants exposed to a mixture of pollutants. Similar results were also observed in keratinocytes exposed to urban dust. Moreover, the ingredient significantly reduced pollutant-induced ROS production in human endothelial cells and lung fibroblasts, while downregulating the expression of apoptotic genes (bcl-2 and bax) in lung fibroblasts. Additionally, the blend counteracted the effect of urban dust on the heart rate in zebrafish embryos. These results support the potential use of this supplement as an adjuvant method to reduce the impact of environmental pollution on the skin, lungs, and cardiovascular tissues. |
| first_indexed | 2024-03-07T22:37:41Z |
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| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-07T22:37:41Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-744aab6da081417c92075a677a7789bc2024-02-23T15:12:39ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452024-02-014621530155510.3390/cimb46020099Protective Potential of a Botanical-Based Supplement Ingredient against the Impact of Environmental Pollution on Cutaneous and Cardiopulmonary Systems: Preclinical StudyLaurent Peno-Mazzarino0Nikita Radionov1Marián Merino2Sonia González3José L. Mullor4Jonathan Jones5Nuria Caturla6Laboratoire BIO-EC, Chemin de Saulxier 1, 91160 Longjumeau, FranceLaboratoire BIO-EC, Chemin de Saulxier 1, 91160 Longjumeau, FranceBionos Biotech, S.L. Biopolo La Fe, Av. Fernando Abril Martorell, 106, 46026 Valencia, SpainBionos Biotech, S.L. Biopolo La Fe, Av. Fernando Abril Martorell, 106, 46026 Valencia, SpainBionos Biotech, S.L. Biopolo La Fe, Av. Fernando Abril Martorell, 106, 46026 Valencia, SpainMonteloeder SA, Miguel Servet 16, 03203 Elche, SpainMonteloeder SA, Miguel Servet 16, 03203 Elche, SpainAir pollution is a growing threat to human health. Airborne pollution effects on respiratory, cardiovascular and skin health are well-established. The main mechanisms of air-pollution-induced health effects involve oxidative stress and inflammation. The present study evaluates the potential of a polyphenol-enriched food supplement ingredient comprising <i>Lippia citriodora</i>, <i>Olea europaea</i>, <i>Rosmarinus officinalis</i>, and <i>Sophora japonica</i> extracts in mitigating the adverse effects of environmental pollution on skin and cardiopulmonary systems. Both in vitro and ex vivo studies were used to assess the blend’s effects against pollution-induced damage. In these studies, the botanical blend was found to reduce lipid peroxidation, inflammation (by reducing IL-1α), and metabolic alterations (by regulating MT-1H, AhR, and Nrf2 expression) in human skin explants exposed to a mixture of pollutants. Similar results were also observed in keratinocytes exposed to urban dust. Moreover, the ingredient significantly reduced pollutant-induced ROS production in human endothelial cells and lung fibroblasts, while downregulating the expression of apoptotic genes (bcl-2 and bax) in lung fibroblasts. Additionally, the blend counteracted the effect of urban dust on the heart rate in zebrafish embryos. These results support the potential use of this supplement as an adjuvant method to reduce the impact of environmental pollution on the skin, lungs, and cardiovascular tissues.https://www.mdpi.com/1467-3045/46/2/99air pollutionskin damageplant polyphenolsnutraceuticalskin explantshuman keratinocytes |
| spellingShingle | Laurent Peno-Mazzarino Nikita Radionov Marián Merino Sonia González José L. Mullor Jonathan Jones Nuria Caturla Protective Potential of a Botanical-Based Supplement Ingredient against the Impact of Environmental Pollution on Cutaneous and Cardiopulmonary Systems: Preclinical Study Current Issues in Molecular Biology air pollution skin damage plant polyphenols nutraceutical skin explants human keratinocytes |
| title | Protective Potential of a Botanical-Based Supplement Ingredient against the Impact of Environmental Pollution on Cutaneous and Cardiopulmonary Systems: Preclinical Study |
| title_full | Protective Potential of a Botanical-Based Supplement Ingredient against the Impact of Environmental Pollution on Cutaneous and Cardiopulmonary Systems: Preclinical Study |
| title_fullStr | Protective Potential of a Botanical-Based Supplement Ingredient against the Impact of Environmental Pollution on Cutaneous and Cardiopulmonary Systems: Preclinical Study |
| title_full_unstemmed | Protective Potential of a Botanical-Based Supplement Ingredient against the Impact of Environmental Pollution on Cutaneous and Cardiopulmonary Systems: Preclinical Study |
| title_short | Protective Potential of a Botanical-Based Supplement Ingredient against the Impact of Environmental Pollution on Cutaneous and Cardiopulmonary Systems: Preclinical Study |
| title_sort | protective potential of a botanical based supplement ingredient against the impact of environmental pollution on cutaneous and cardiopulmonary systems preclinical study |
| topic | air pollution skin damage plant polyphenols nutraceutical skin explants human keratinocytes |
| url | https://www.mdpi.com/1467-3045/46/2/99 |
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