Arbutin: Occurrence in Plants, and Its Potential as an Anticancer Agent
Arbutin, a hydroquinone glucoside, has been detected in ca. 50 plant families, especially in the plants of the Asteraceae, Ericaceae, Proteaceae and Rosaceae families. It is one of the most widely used natural skin-whitening agents. In addition to its skin whitening property, arbutin possesses other...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/24/8786 |
| _version_ | 1797456083187400704 |
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| author | Lutfun Nahar Afaf Al-Groshi Anil Kumar Satyajit D. Sarker |
| author_facet | Lutfun Nahar Afaf Al-Groshi Anil Kumar Satyajit D. Sarker |
| author_sort | Lutfun Nahar |
| collection | DOAJ |
| description | Arbutin, a hydroquinone glucoside, has been detected in ca. 50 plant families, especially in the plants of the Asteraceae, Ericaceae, Proteaceae and Rosaceae families. It is one of the most widely used natural skin-whitening agents. In addition to its skin whitening property, arbutin possesses other therapeutically relevant biological properties, e.g., antioxidant, antimicrobial and anti-inflammatory, as well as anticancer potential. This review presents, for the first time, a comprehensive overview of the distribution of arbutin in the plant kingdom and critically appraises its therapeutic potential as an anticancer agent based on the literature published until the end of August 2022, accessed via several databases, e.g., Web of Science, Science Direct, Dictionary of Natural Products, PubMed and Google Scholar. The keywords used in the search were arbutin, cancer, anticancer, distribution and hydroquinone. Published outputs suggest that arbutin has potential anticancer properties against bladder, bone, brain, breast, cervix, colon, liver, prostate and skin cancers and a low level of acute or chronic toxicity. |
| first_indexed | 2024-03-09T16:02:18Z |
| format | Article |
| id | doaj.art-744abfe9b68f42e58f2a667e53f39eb6 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T16:02:18Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-744abfe9b68f42e58f2a667e53f39eb62023-11-24T16:57:24ZengMDPI AGMolecules1420-30492022-12-012724878610.3390/molecules27248786Arbutin: Occurrence in Plants, and Its Potential as an Anticancer AgentLutfun Nahar0Afaf Al-Groshi1Anil Kumar2Satyajit D. Sarker3Laboratory of Growth Regulators, Palacký University and Institute of Experimental Botany, The Czech Academy of Sciences, Šlechtitelů 27, 78371 Olomouc, Czech RepublicCentre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, UKDepartment of Biotechnology, Government V. Y. T. PG Autonomous College, Durg 491001, Chhattisgarh, IndiaCentre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, UKArbutin, a hydroquinone glucoside, has been detected in ca. 50 plant families, especially in the plants of the Asteraceae, Ericaceae, Proteaceae and Rosaceae families. It is one of the most widely used natural skin-whitening agents. In addition to its skin whitening property, arbutin possesses other therapeutically relevant biological properties, e.g., antioxidant, antimicrobial and anti-inflammatory, as well as anticancer potential. This review presents, for the first time, a comprehensive overview of the distribution of arbutin in the plant kingdom and critically appraises its therapeutic potential as an anticancer agent based on the literature published until the end of August 2022, accessed via several databases, e.g., Web of Science, Science Direct, Dictionary of Natural Products, PubMed and Google Scholar. The keywords used in the search were arbutin, cancer, anticancer, distribution and hydroquinone. Published outputs suggest that arbutin has potential anticancer properties against bladder, bone, brain, breast, cervix, colon, liver, prostate and skin cancers and a low level of acute or chronic toxicity.https://www.mdpi.com/1420-3049/27/24/8786arbutinanticancerdistributionhydroquinone |
| spellingShingle | Lutfun Nahar Afaf Al-Groshi Anil Kumar Satyajit D. Sarker Arbutin: Occurrence in Plants, and Its Potential as an Anticancer Agent Molecules arbutin anticancer distribution hydroquinone |
| title | Arbutin: Occurrence in Plants, and Its Potential as an Anticancer Agent |
| title_full | Arbutin: Occurrence in Plants, and Its Potential as an Anticancer Agent |
| title_fullStr | Arbutin: Occurrence in Plants, and Its Potential as an Anticancer Agent |
| title_full_unstemmed | Arbutin: Occurrence in Plants, and Its Potential as an Anticancer Agent |
| title_short | Arbutin: Occurrence in Plants, and Its Potential as an Anticancer Agent |
| title_sort | arbutin occurrence in plants and its potential as an anticancer agent |
| topic | arbutin anticancer distribution hydroquinone |
| url | https://www.mdpi.com/1420-3049/27/24/8786 |
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