Biophysical analysis of apolipoprotein E3 variants linked with development of type III hyperlipoproteinemia.

Biophysical analysis of apolipoprotein E3 variants linked with development of type III hyperlipoproteinemia.

Apolipoprotein E (apoE) is a major protein of the lipoprotein transport system that plays important roles in lipid homeostasis and protection from atherosclerosis. ApoE is characterized by structural plasticity and thermodynamic instability and can undergo significant structural rearrangements as pa...

Full description

Bibliographic Details
Main Authors:	Dimitra Georgiadou, Angeliki Chroni, Alexander Vezeridis, Vassilis I Zannis, Efstratios Stratikos
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2011-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3206067?pdf=render

Similar Items

Molecular etiology of a dominant form of type III hyperlipoproteinemia caused by R142C substitution in apoE4[S]
by: Alexander M. Vezeridis, et al.
Published: (2011-01-01)

Role of the hydrophobic and charged residues in the 218–226 region of apoA-I in the biogenesis of HDL1[S]
by: Panagiotis Fotakis, et al.
Published: (2013-12-01)

Familial apolipoprotein E deficiency and type III hyperlipoproteinemia due to a premature stop codon in the apolipoprotein E gene.
by: P Lohse, et al.
Published: (1992-11-01)

apoE3[K146N/R147W] acts as a dominant negative apoE form that prevents remnant clearance and inhibits the biogenesis of HDL[S]
by: Panagiotis Fotakis, et al.
Published: (2014-07-01)

Normolipemic dysbetalipoproteinemia and hyperlipoproteinemia type III in subjects homozygous for a rare genetic apolipoprotein E variant (apoE1).
by: A Steinmetz, et al.
Published: (1990-06-01)

FAMILIAL DYSBETALIPOPROTEINEMIA (TYPE III HYPERLIPOPROTEINEMIA)
by: P. P. Malyshev, et al.
Published: (2019-03-01)

Thermodynamic and structural destabilization of apoE3 by hereditary mutations associated with the development of lipoprotein glomerulopathy[S]
by: Dimitra Georgiadou, et al.
Published: (2013-01-01)

Significance of the hydrophobic residues 225–230 of apoA-I for the biogenesis of HDL1[S]
by: Panagiotis Fotakis, et al.
Published: (2013-12-01)

Apolipoprotein E isoforms and rare mutations: parallel reduction in binding to cells and to heparin reflects severity of associated type III hyperlipoproteinemia.
by: W A Mann, et al.
Published: (1995-03-01)

Studies of familial type III hyperlipoproteinemia using as a genetic marker the apoE phenotype E2/2
by: J L Breslow, et al.
Published: (1982-11-01)

Effect of apoA-I Mutations in the Capacity of Reconstituted HDL to Promote ABCG1-Mediated Cholesterol Efflux.
by: Georgios Daniil, et al.
Published: (2013-01-01)

PARTICIPATION OF APOLIPOPROTEIN E IN TRANSFER AND ABSORPTION OF FATTY ACIDS BY THE CELLS And CAUSING OF HYPERLIPOPROTEINEMIA
by: V. N. Titov, et al.
Published: (2014-02-01)

Pathogenesis of hyperlipoproteinemia
by: S M Grundy
Published: (1984-12-01)

Overexpression of human apolipoprotein A-I in transgenic rats and the hyperlipoproteinemia associated with experimental nephrosis
by: B F Burkey, et al.
Published: (1995-07-01)

Hyperlipoproteinemia in fasting ponies
by: M.D. Morris, et al.
Published: (1972-05-01)

Hyperlipoproteinemia(a) and Severe Coronary Artery Lesion Types
by: Larisa N. Ilina, et al.
Published: (2022-11-01)

Therapeutic management of hyperlipoproteinemia (a)
by: Constantine E Kosmas, et al.
Published: (2019-09-01)

C3 POLYMORPHISM IN HYPERLIPOPROTEINEMIA (HLP)
by: D.D. FARHUD
Published: (1989-08-01)

Identification and Characterization of Two Novel Compounds: Heterozygous Variants of Lipoprotein Lipase in Two Pedigrees With Type I Hyperlipoproteinemia
by: Shuping Wang, et al.
Published: (2022-07-01)

ApoB-48 and apoB-100 differentially influence the expression of type-III hyperlipoproteinemia in APOE*2 mice
by: Myron E. Hinsdale, et al.
Published: (2002-09-01)

Novel Pharmacological Therapies for the Management of Hyperlipoproteinemia(a)
by: Constantine E. Kosmas, et al.
Published: (2023-09-01)

Assessment of the Relationship between Hyperlipoproteinemias and Biliary Lithiasis
by: Dan BANUT, et al.
Published: (2009-01-01)

Bile acid kinetics in relation to endogenous tryglyceride metabolism in various types of hyperlipoproteinemia.
by: B Angelin, et al.
Published: (1978-11-01)

Apolipoprotein A-I of primates.
by: R J Nicolosi, et al.
Published: (1984-09-01)

ABCA1 and amphipathic apolipoproteins form high-affinity molecular complexes required for cholesterol efflux
by: M.L. Fitzgerald, et al.
Published: (2004-02-01)

Alteration of negatively charged residues in the 89 to 99 domain of apoA-I affects lipid homeostasis and maturation of HDL[S]
by: Andreas K. Kateifides, et al.
Published: (2011-07-01)

Lack of association of the apolipoprotein A-I-C-III-A-IV gene XmnI and SstI polymorphisms and of the lipoprotein lipase gene mutations in familial combined hyperlipoproteinemia in French Canadian subjects
by: M Marcil, et al.
Published: (1996-02-01)

Identification of an apoC-II variant (apoC-IIBethesda) in a kindred with apoC-II deficiency and type I hyperlipoproteinemia.
by: D L Sprecher, et al.
Published: (1988-03-01)

Molecular basis of lipoprotein lipase deficiency in two Austrian families with type I hyperlipoproteinemia.
by: Paulweber, B, et al.
Published: (1991)

Management of Patients with Type V Hyperlipoproteinemia: An Uncommon Phenotype of Dyslipidemia with Chylomicronemia and Severe Hypertriglyceridemia
by: Ya-Hui Chang, et al.
Published: (2022-12-01)

The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.
by: Irini Evnouchidou, et al.
Published: (2008-01-01)

Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation
by: Athanasios Papakyriakou, et al.
Published: (2022-04-01)

Fenofibrate improves postprandial chylomicron clearance in II B hyperlipoproteinemia.
by: Föger, B, et al.
Published: (1994)

Aggressive course of atherosclerosis in hyperlipoproteinemia (a): a case series
by: A. M. Namitokov, et al.
Published: (2023-12-01)

Ghrelin Levels in Male Patients with Hyperlipoproteinemia I, II versus Type 2 Diabetes Mellitus.
by: Salma A. Abbas, et al.
Published: (2014-07-01)

Case report of one month and 15 days old baby with type V hyperlipoproteinemia (HLP)
by: Shabnam Dildar, et al.
Published: (2020-02-01)

Familial apolipoprotein A-I and C-III deficiency, variant II.
by: E J Schaefer, et al.
Published: (1985-09-01)

Cross interactions between Apolipoprotein E and amyloid proteins in neurodegenerative diseases
by: Rolf Antonie Loch, et al.
Published: (2023-01-01)

Subcutaneous NPH Insulin for Severe Hypertriglyceridemia in a Pregnant Patient with Type V Hyperlipoproteinemia: a Case Report
by: Mustafa Kemal Balcı, et al.
Published: (2012-06-01)

Hyperlipoproteinemia type I in a patient with active lipoprotein lipase in adipose tissue and indications of defective transport of the enzyme.
by: G Fager, et al.
Published: (1990-07-01)