Rotavirus Infection and Cytopathogenesis in Human Biliary Organoids Potentially Recapitulate Biliary Atresia Development

Rotavirus Infection and Cytopathogenesis in Human Biliary Organoids Potentially Recapitulate Biliary Atresia Development

ABSTRACT Biliary atresia (BA) is a neonatal liver disease characterized by progressive fibroinflammatory obliteration of both intrahepatic and extrahepatic bile ducts. The etiologies of BA remain largely unknown, but rotavirus infection has been implicated at least for a subset of patients, and this...

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Main Authors: Sunrui Chen, Pengfei Li, Yining Wang, Yuebang Yin, Petra E. de Ruiter, Monique M. A. Verstegen, Maikel P. Peppelenbosch, Luc J. W. van der Laan, Qiuwei Pan
Format: Article
Language:English
Published: American Society for Microbiology 2020-08-01
Series:mBio
Subjects:
biliary atresia
rotavirus infection
human organoids
Online Access:https://journals.asm.org/doi/10.1128/mBio.01968-20

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