Genipin Cross-Linked Decellularized Nucleus Pulposus Hydrogel-Like Cell Delivery System Induces Differentiation of ADSCs and Retards Intervertebral Disc Degeneration

Genipin Cross-Linked Decellularized Nucleus Pulposus Hydrogel-Like Cell Delivery System Induces Differentiation of ADSCs and Retards Intervertebral Disc Degeneration

Intervertebral disc degeneration (IDD) is the pathological basis of disc degenerative diseases (DDD). Reduction in the number of cells and degeneration of the extracellular matrix (ECM) in the nucleus pulposus (NP) are characteristics of IDD. Bio-hydrogel combined with stem cell transplantation is a...

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Bibliographic Details
Main Authors: Lei Yu, Yi Liu, Jianxin Wu, Shuang Wang, Jiangming Yu, Weiheng Wang, Xiaojian Ye
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
intervertebral disc degeneration
genipin
nucleus pulposus
ADSC
tissue engineering
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.807883/full

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