Extracellular Vesicles: A New Frontier for Cardiac Repair
The ability of extracellular vesicles (EVs) to regulate a broad range of cellular processes has recently been used to treat diseases. Growing evidence indicates that EVs play a cardioprotective role in heart disease by activating beneficial signaling pathways. Multiple functional components of EVs a...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/9/1848 |
| _version_ | 1797483606878191616 |
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| author | Benshuai You Yang Yang Zixuan Zhou Yongmin Yan Leilei Zhang Jianhua Jin Hui Qian |
| author_facet | Benshuai You Yang Yang Zixuan Zhou Yongmin Yan Leilei Zhang Jianhua Jin Hui Qian |
| author_sort | Benshuai You |
| collection | DOAJ |
| description | The ability of extracellular vesicles (EVs) to regulate a broad range of cellular processes has recently been used to treat diseases. Growing evidence indicates that EVs play a cardioprotective role in heart disease by activating beneficial signaling pathways. Multiple functional components of EVs and intracellular molecular mechanisms are involved in the process. To overcome the shortcomings of native EVs such as their heterogeneity and limited tropism, a series of engineering approaches has been developed to improve the therapeutic efficiency of EVs. In this review, we present an overview of the research and future directions for EVs-based cardiac therapies with an emphasis on EVs-mediated delivery of therapeutic agents. The advantages and limitations of various modification strategies are discussed, and possible opportunities for improvement are proposed. An in-depth understanding of the endogenous properties of EVs and EVs engineering strategies could lead to a promising cell-free therapy for cardiac repair. |
| first_indexed | 2024-03-09T22:50:24Z |
| format | Article |
| id | doaj.art-7450eb119b6a48c8a516cdcfc08c43b6 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T22:50:24Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-7450eb119b6a48c8a516cdcfc08c43b62023-11-23T18:21:40ZengMDPI AGPharmaceutics1999-49232022-09-01149184810.3390/pharmaceutics14091848Extracellular Vesicles: A New Frontier for Cardiac RepairBenshuai You0Yang Yang1Zixuan Zhou2Yongmin Yan3Leilei Zhang4Jianhua Jin5Hui Qian6Wujin Institute of Molecular Diagnostics and Precision Cancer Medicine of Jiangsu University, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213017, ChinaClinical Laboratory Center, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou 225317, ChinaJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, ChinaWujin Institute of Molecular Diagnostics and Precision Cancer Medicine of Jiangsu University, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213017, ChinaJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, ChinaWujin Institute of Molecular Diagnostics and Precision Cancer Medicine of Jiangsu University, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213017, ChinaJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, ChinaThe ability of extracellular vesicles (EVs) to regulate a broad range of cellular processes has recently been used to treat diseases. Growing evidence indicates that EVs play a cardioprotective role in heart disease by activating beneficial signaling pathways. Multiple functional components of EVs and intracellular molecular mechanisms are involved in the process. To overcome the shortcomings of native EVs such as their heterogeneity and limited tropism, a series of engineering approaches has been developed to improve the therapeutic efficiency of EVs. In this review, we present an overview of the research and future directions for EVs-based cardiac therapies with an emphasis on EVs-mediated delivery of therapeutic agents. The advantages and limitations of various modification strategies are discussed, and possible opportunities for improvement are proposed. An in-depth understanding of the endogenous properties of EVs and EVs engineering strategies could lead to a promising cell-free therapy for cardiac repair.https://www.mdpi.com/1999-4923/14/9/1848extracellular vesiclesheart diseasemesenchymal stem cellstargeted delivery |
| spellingShingle | Benshuai You Yang Yang Zixuan Zhou Yongmin Yan Leilei Zhang Jianhua Jin Hui Qian Extracellular Vesicles: A New Frontier for Cardiac Repair Pharmaceutics extracellular vesicles heart disease mesenchymal stem cells targeted delivery |
| title | Extracellular Vesicles: A New Frontier for Cardiac Repair |
| title_full | Extracellular Vesicles: A New Frontier for Cardiac Repair |
| title_fullStr | Extracellular Vesicles: A New Frontier for Cardiac Repair |
| title_full_unstemmed | Extracellular Vesicles: A New Frontier for Cardiac Repair |
| title_short | Extracellular Vesicles: A New Frontier for Cardiac Repair |
| title_sort | extracellular vesicles a new frontier for cardiac repair |
| topic | extracellular vesicles heart disease mesenchymal stem cells targeted delivery |
| url | https://www.mdpi.com/1999-4923/14/9/1848 |
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