Haematological and biochemical predictors of bone marrow metastases in non-haematological malignancies: A clinico-pathological analysis
Background: Bone marrow metastasis is an uncommon yet significant presentation of many non haematological malignancies. Aims: The present study was conducted with the aim of analysing the clinical, haematological and biochemical parameters of the patients with bone marrow metastases and determines t...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Journal of Medical Evidence |
| Subjects: | |
| Online Access: | http://www.journaljme.org/article.asp?issn=2667-0720;year=2022;volume=3;issue=2;spage=123;epage=129;aulast=Agrawal |
| _version_ | 1818482547232866304 |
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| author | Shruti Agrawal Rekha Bhandari Vinay N Gowda Amit Gupta Neha Singh Nilotpal Chowdhury Shalinee Rao Sanjeev Kishore Arvind Kumar Gupta Harish Chandra |
| author_facet | Shruti Agrawal Rekha Bhandari Vinay N Gowda Amit Gupta Neha Singh Nilotpal Chowdhury Shalinee Rao Sanjeev Kishore Arvind Kumar Gupta Harish Chandra |
| author_sort | Shruti Agrawal |
| collection | DOAJ |
| description | Background: Bone marrow metastasis is an uncommon yet significant presentation of many non haematological malignancies. Aims: The present study was conducted with the aim of analysing the clinical, haematological and biochemical parameters of the patients with bone marrow metastases and determines the parameters which could possibly indicate the presence of bone marrow metastases. Patients and Methods: Bone marrow aspirate, imprint and biopsy slides of 22 cases with bone marrow metastases were reviewed and the haematological and biochemical data of all these cases were compared with that of 20 controls without any evidence of metastases. Results: The mean values of mean platelet volume (MPV), neutrophil to lymphocyte ratio (NLR) and serum lactate dehydrogenase (LDH) were found to be significantly different (P < 0.001) between the cases and controls. MPV <8.1 fL, NLR >3.5 and LDH >452 U/L showed a high likelihood ratio in predicting bone marrow metastases. Conclusion: Parameters such as MPV, NLR and LDH can be used as efficient and easily available methods to predict bone marrow metastasis for a rapid diagnosis. |
| first_indexed | 2024-12-10T11:48:45Z |
| format | Article |
| id | doaj.art-7452eeeb1d244ca98848f65eb881e0ed |
| institution | Directory Open Access Journal |
| issn | 2667-0720 2667-0739 |
| language | English |
| last_indexed | 2024-12-10T11:48:45Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Medical Evidence |
| spelling | doaj.art-7452eeeb1d244ca98848f65eb881e0ed2022-12-22T01:50:00ZengWolters Kluwer Medknow PublicationsJournal of Medical Evidence2667-07202667-07392022-01-013212312910.4103/JME.JME_129_20Haematological and biochemical predictors of bone marrow metastases in non-haematological malignancies: A clinico-pathological analysisShruti AgrawalRekha BhandariVinay N GowdaAmit GuptaNeha SinghNilotpal ChowdhuryShalinee RaoSanjeev KishoreArvind Kumar GuptaHarish ChandraBackground: Bone marrow metastasis is an uncommon yet significant presentation of many non haematological malignancies. Aims: The present study was conducted with the aim of analysing the clinical, haematological and biochemical parameters of the patients with bone marrow metastases and determines the parameters which could possibly indicate the presence of bone marrow metastases. Patients and Methods: Bone marrow aspirate, imprint and biopsy slides of 22 cases with bone marrow metastases were reviewed and the haematological and biochemical data of all these cases were compared with that of 20 controls without any evidence of metastases. Results: The mean values of mean platelet volume (MPV), neutrophil to lymphocyte ratio (NLR) and serum lactate dehydrogenase (LDH) were found to be significantly different (P < 0.001) between the cases and controls. MPV <8.1 fL, NLR >3.5 and LDH >452 U/L showed a high likelihood ratio in predicting bone marrow metastases. Conclusion: Parameters such as MPV, NLR and LDH can be used as efficient and easily available methods to predict bone marrow metastasis for a rapid diagnosis.http://www.journaljme.org/article.asp?issn=2667-0720;year=2022;volume=3;issue=2;spage=123;epage=129;aulast=Agrawalbone marrowlactate dehydrogenasemean platelet volumemetastasesneutrophil to lymphocyte ratio |
| spellingShingle | Shruti Agrawal Rekha Bhandari Vinay N Gowda Amit Gupta Neha Singh Nilotpal Chowdhury Shalinee Rao Sanjeev Kishore Arvind Kumar Gupta Harish Chandra Haematological and biochemical predictors of bone marrow metastases in non-haematological malignancies: A clinico-pathological analysis Journal of Medical Evidence bone marrow lactate dehydrogenase mean platelet volume metastases neutrophil to lymphocyte ratio |
| title | Haematological and biochemical predictors of bone marrow metastases in non-haematological malignancies: A clinico-pathological analysis |
| title_full | Haematological and biochemical predictors of bone marrow metastases in non-haematological malignancies: A clinico-pathological analysis |
| title_fullStr | Haematological and biochemical predictors of bone marrow metastases in non-haematological malignancies: A clinico-pathological analysis |
| title_full_unstemmed | Haematological and biochemical predictors of bone marrow metastases in non-haematological malignancies: A clinico-pathological analysis |
| title_short | Haematological and biochemical predictors of bone marrow metastases in non-haematological malignancies: A clinico-pathological analysis |
| title_sort | haematological and biochemical predictors of bone marrow metastases in non haematological malignancies a clinico pathological analysis |
| topic | bone marrow lactate dehydrogenase mean platelet volume metastases neutrophil to lymphocyte ratio |
| url | http://www.journaljme.org/article.asp?issn=2667-0720;year=2022;volume=3;issue=2;spage=123;epage=129;aulast=Agrawal |
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