Factors Associated with the Effectiveness of Regimens for the Treatment of Tuberculosis in Patients Coinfected with HIV/AIDS: Cohort 2015 to 2019
(1) Background: Infection with the Human Immunodeficiency Virus (HIV) is a significant challenge for tuberculosis (TB) control, with increasing mortality rates worldwide. Moreover, the loss to follow-up is very high, with low adherence to treatment, resulting in unfavorable endpoints. This study aim...
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| Format: | Article |
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MDPI AG
2023-03-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/6/1181 |
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| author | Natália Helena de Resende Silvana Spíndola de Miranda Adriano Max Moreira Reis Cristiane Aparecida Menezes de Pádua João Paulo Amaral Haddad Paulo Vitor Rozario da Silva Dirce Inês da Silva Wânia da Silva Carvalho |
| author_facet | Natália Helena de Resende Silvana Spíndola de Miranda Adriano Max Moreira Reis Cristiane Aparecida Menezes de Pádua João Paulo Amaral Haddad Paulo Vitor Rozario da Silva Dirce Inês da Silva Wânia da Silva Carvalho |
| author_sort | Natália Helena de Resende |
| collection | DOAJ |
| description | (1) Background: Infection with the Human Immunodeficiency Virus (HIV) is a significant challenge for tuberculosis (TB) control, with increasing mortality rates worldwide. Moreover, the loss to follow-up is very high, with low adherence to treatment, resulting in unfavorable endpoints. This study aimed to analyze the effectiveness of TB treatment in patients coinfected with HIV/AIDS and its associated factors. (2) Methods: Patients coinfected with TB and HIV/AIDS at a Reference Hospital for infectious diseases were followed up for a maximum of one year from the start of TB treatment until cure or censorship (death, abandonment, and transfer) from 2015 to 2019. The Cox proportional model was used to identify risk factors for effectiveness. (3) Results: Of the 244 patients included in the cohort, 58.2% (142/244) had no treatment effectiveness, 12.3% (30/244) died, and 11.1% (27/244) abandoned treatment. Viral suppression at the onset of TB treatment (HR = 1.961, CI = 1.123–3.422), previous use of Antiretroviral Therapy (HR = 1.676, CI = 1.060–2.651), new cases (HR = 2.407, CI = 1.197–3.501), not using illicit drugs (HR = 1.763, CI = 1.141–2.723), and using the basic TB regimen (HR = 1.864, CI = 1.084–3.205) were significant variables per the multivariate Cox regression analysis. (4) Conclusion: TB treatment for most TB patients coinfected with HIV/AIDS was not effective. This study identified that an undetectable viral load at the beginning of the disease, previous use of ART, not using illicit drugs and not having previously taken anti-TB treatment are factors associated with successful TB treatment. |
| first_indexed | 2024-03-11T06:40:52Z |
| format | Article |
| id | doaj.art-7454a34f72bc4a87a565834f18b3babf |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T06:40:52Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-7454a34f72bc4a87a565834f18b3babf2023-11-17T10:35:27ZengMDPI AGDiagnostics2075-44182023-03-01136118110.3390/diagnostics13061181Factors Associated with the Effectiveness of Regimens for the Treatment of Tuberculosis in Patients Coinfected with HIV/AIDS: Cohort 2015 to 2019Natália Helena de Resende0Silvana Spíndola de Miranda1Adriano Max Moreira Reis2Cristiane Aparecida Menezes de Pádua3João Paulo Amaral Haddad4Paulo Vitor Rozario da Silva5Dirce Inês da Silva6Wânia da Silva Carvalho7College of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, BrazilCollege of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, BrazilCollege of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, BrazilCollege of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, BrazilSchool of Veterinary, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, BrazilCollege of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, BrazilHospital Foundation of the State of Minas Gerais/Eduardo de Menezes Hospital, Belo Horizonte 30622-020, BrazilCollege of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil(1) Background: Infection with the Human Immunodeficiency Virus (HIV) is a significant challenge for tuberculosis (TB) control, with increasing mortality rates worldwide. Moreover, the loss to follow-up is very high, with low adherence to treatment, resulting in unfavorable endpoints. This study aimed to analyze the effectiveness of TB treatment in patients coinfected with HIV/AIDS and its associated factors. (2) Methods: Patients coinfected with TB and HIV/AIDS at a Reference Hospital for infectious diseases were followed up for a maximum of one year from the start of TB treatment until cure or censorship (death, abandonment, and transfer) from 2015 to 2019. The Cox proportional model was used to identify risk factors for effectiveness. (3) Results: Of the 244 patients included in the cohort, 58.2% (142/244) had no treatment effectiveness, 12.3% (30/244) died, and 11.1% (27/244) abandoned treatment. Viral suppression at the onset of TB treatment (HR = 1.961, CI = 1.123–3.422), previous use of Antiretroviral Therapy (HR = 1.676, CI = 1.060–2.651), new cases (HR = 2.407, CI = 1.197–3.501), not using illicit drugs (HR = 1.763, CI = 1.141–2.723), and using the basic TB regimen (HR = 1.864, CI = 1.084–3.205) were significant variables per the multivariate Cox regression analysis. (4) Conclusion: TB treatment for most TB patients coinfected with HIV/AIDS was not effective. This study identified that an undetectable viral load at the beginning of the disease, previous use of ART, not using illicit drugs and not having previously taken anti-TB treatment are factors associated with successful TB treatment.https://www.mdpi.com/2075-4418/13/6/1181tuberculosisHIVAIDScoinfectioneffectivenessdrug therapy |
| spellingShingle | Natália Helena de Resende Silvana Spíndola de Miranda Adriano Max Moreira Reis Cristiane Aparecida Menezes de Pádua João Paulo Amaral Haddad Paulo Vitor Rozario da Silva Dirce Inês da Silva Wânia da Silva Carvalho Factors Associated with the Effectiveness of Regimens for the Treatment of Tuberculosis in Patients Coinfected with HIV/AIDS: Cohort 2015 to 2019 Diagnostics tuberculosis HIV AIDS coinfection effectiveness drug therapy |
| title | Factors Associated with the Effectiveness of Regimens for the Treatment of Tuberculosis in Patients Coinfected with HIV/AIDS: Cohort 2015 to 2019 |
| title_full | Factors Associated with the Effectiveness of Regimens for the Treatment of Tuberculosis in Patients Coinfected with HIV/AIDS: Cohort 2015 to 2019 |
| title_fullStr | Factors Associated with the Effectiveness of Regimens for the Treatment of Tuberculosis in Patients Coinfected with HIV/AIDS: Cohort 2015 to 2019 |
| title_full_unstemmed | Factors Associated with the Effectiveness of Regimens for the Treatment of Tuberculosis in Patients Coinfected with HIV/AIDS: Cohort 2015 to 2019 |
| title_short | Factors Associated with the Effectiveness of Regimens for the Treatment of Tuberculosis in Patients Coinfected with HIV/AIDS: Cohort 2015 to 2019 |
| title_sort | factors associated with the effectiveness of regimens for the treatment of tuberculosis in patients coinfected with hiv aids cohort 2015 to 2019 |
| topic | tuberculosis HIV AIDS coinfection effectiveness drug therapy |
| url | https://www.mdpi.com/2075-4418/13/6/1181 |
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