Activin receptor-like kinase 3: a critical modulator of development and function of mineralized tissues
Mineralized tissues, such as teeth and bones, pose significant challenges for repair due to their hardness, low permeability, and limited blood flow compared to soft tissues. Bone morphogenetic proteins (BMPs) have been identified as playing a crucial role in mineralized tissue formation and repair....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1209817/full |
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| author | Xianchun Ruan Xianchun Ruan Zhaowei Zhang Zhaowei Zhang Munire Aili Munire Aili Xiang Luo Xiang Luo Xiang Luo Qiang Wei Qiang Wei Demao Zhang Demao Zhang Demao Zhang Mingru Bai Mingru Bai Mingru Bai |
| author_facet | Xianchun Ruan Xianchun Ruan Zhaowei Zhang Zhaowei Zhang Munire Aili Munire Aili Xiang Luo Xiang Luo Xiang Luo Qiang Wei Qiang Wei Demao Zhang Demao Zhang Demao Zhang Mingru Bai Mingru Bai Mingru Bai |
| author_sort | Xianchun Ruan |
| collection | DOAJ |
| description | Mineralized tissues, such as teeth and bones, pose significant challenges for repair due to their hardness, low permeability, and limited blood flow compared to soft tissues. Bone morphogenetic proteins (BMPs) have been identified as playing a crucial role in mineralized tissue formation and repair. However, the application of large amounts of exogenous BMPs may cause side effects such as inflammation. Therefore, it is necessary to identify a more precise molecular target downstream of the ligands. Activin receptor-like kinase 3 (ALK3), a key transmembrane receptor, serves as a vital gateway for the transmission of BMP signals, triggering cellular responses. Recent research has yielded new insights into the regulatory roles of ALK3 in mineralized tissues. Experimental knockout or mutation of ALK3 has been shown to result in skeletal dysmorphisms and failure of tooth formation, eruption, and orthodontic tooth movement. This review summarizes the roles of ALK3 in mineralized tissue regulation and elucidates how ALK3-mediated signaling influences the physiology and pathology of teeth and bones. Additionally, this review provides a reference for recommended basic research and potential future treatment strategies for the repair and regeneration of mineralized tissues. |
| first_indexed | 2024-03-13T02:16:03Z |
| format | Article |
| id | doaj.art-7454d97dea174c43973fd86953e5f219 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-13T02:16:03Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-7454d97dea174c43973fd86953e5f2192023-06-30T12:49:13ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-06-011110.3389/fcell.2023.12098171209817Activin receptor-like kinase 3: a critical modulator of development and function of mineralized tissuesXianchun Ruan0Xianchun Ruan1Zhaowei Zhang2Zhaowei Zhang3Munire Aili4Munire Aili5Xiang Luo6Xiang Luo7Xiang Luo8Qiang Wei9Qiang Wei10Demao Zhang11Demao Zhang12Demao Zhang13Mingru Bai14Mingru Bai15Mingru Bai16State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaNational Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaNational Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaNational Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaNational Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaWest China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaNational Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaNational Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaWest China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaNational Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaDepartment of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaMineralized tissues, such as teeth and bones, pose significant challenges for repair due to their hardness, low permeability, and limited blood flow compared to soft tissues. Bone morphogenetic proteins (BMPs) have been identified as playing a crucial role in mineralized tissue formation and repair. However, the application of large amounts of exogenous BMPs may cause side effects such as inflammation. Therefore, it is necessary to identify a more precise molecular target downstream of the ligands. Activin receptor-like kinase 3 (ALK3), a key transmembrane receptor, serves as a vital gateway for the transmission of BMP signals, triggering cellular responses. Recent research has yielded new insights into the regulatory roles of ALK3 in mineralized tissues. Experimental knockout or mutation of ALK3 has been shown to result in skeletal dysmorphisms and failure of tooth formation, eruption, and orthodontic tooth movement. This review summarizes the roles of ALK3 in mineralized tissue regulation and elucidates how ALK3-mediated signaling influences the physiology and pathology of teeth and bones. Additionally, this review provides a reference for recommended basic research and potential future treatment strategies for the repair and regeneration of mineralized tissues.https://www.frontiersin.org/articles/10.3389/fcell.2023.1209817/fullactivin receptor-like kinase 3bone morphogenetic proteinmineralized tissuetoothbone |
| spellingShingle | Xianchun Ruan Xianchun Ruan Zhaowei Zhang Zhaowei Zhang Munire Aili Munire Aili Xiang Luo Xiang Luo Xiang Luo Qiang Wei Qiang Wei Demao Zhang Demao Zhang Demao Zhang Mingru Bai Mingru Bai Mingru Bai Activin receptor-like kinase 3: a critical modulator of development and function of mineralized tissues Frontiers in Cell and Developmental Biology activin receptor-like kinase 3 bone morphogenetic protein mineralized tissue tooth bone |
| title | Activin receptor-like kinase 3: a critical modulator of development and function of mineralized tissues |
| title_full | Activin receptor-like kinase 3: a critical modulator of development and function of mineralized tissues |
| title_fullStr | Activin receptor-like kinase 3: a critical modulator of development and function of mineralized tissues |
| title_full_unstemmed | Activin receptor-like kinase 3: a critical modulator of development and function of mineralized tissues |
| title_short | Activin receptor-like kinase 3: a critical modulator of development and function of mineralized tissues |
| title_sort | activin receptor like kinase 3 a critical modulator of development and function of mineralized tissues |
| topic | activin receptor-like kinase 3 bone morphogenetic protein mineralized tissue tooth bone |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1209817/full |
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