Metformin as adjunctive therapy for dengue in overweight and obese patients: a protocol for an open-label clinical trial (MeDO) [version 1; peer review: 2 approved, 1 approved with reservations]

Metformin as adjunctive therapy for dengue in overweight and obese patients: a protocol for an open-label clinical trial (MeDO) [version 1; peer review: 2 approved, 1 approved with reservations]

Background:  Dengue is a disease of major global importance. While most symptomatic infections are mild, a small proportion of patients progress to severe disease with risk of hypovolaemic shock, organ dysfunction and death.  In the absence of effective antiviral or disease modifying drugs, clinical...

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Main Authors: Nguyet Minh Nguyen, Ho Quang Chanh, Dong Thi Hoai Tam, Nguyen Lam Vuong, Nguyen Thi Xuan Chau, Nguyen Van Vinh Chau, Nguyen Thanh Phong, Huynh Trung Trieu, Tai Luong Thi Hue, Tam Cao Thi, Trung Dinh The, Huynh Thi Le Duyen, Ninh Thi Thanh Van, Quyen Nguyen Than Ha, Laura Rivino, Peter Gallagher, Nick K. Jones, Ronald B. Geskus, Evelyne Kestelyn, Sophie Yacoub
Format: Article
Language:English
Published: Wellcome 2020-07-01
Series:Wellcome Open Research
Online Access:https://wellcomeopenresearch.org/articles/5-160/v1

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