Recent Advances in Zika Virus Vaccines
The recent outbreaks of Zika virus (ZIKV) infections and associated microcephaly in newborns has resulted in an unprecedented effort by researchers to target this virus. Significant advances have been made in developing vaccine candidates, treatment strategies and diagnostic assays in a relatively s...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-11-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/10/11/631 |
| _version_ | 1818896595212566528 |
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| author | Himanshu Garg Tugba Mehmetoglu-Gurbuz Anjali Joshi |
| author_facet | Himanshu Garg Tugba Mehmetoglu-Gurbuz Anjali Joshi |
| author_sort | Himanshu Garg |
| collection | DOAJ |
| description | The recent outbreaks of Zika virus (ZIKV) infections and associated microcephaly in newborns has resulted in an unprecedented effort by researchers to target this virus. Significant advances have been made in developing vaccine candidates, treatment strategies and diagnostic assays in a relatively short period of time. Being a preventable disease, the first line of defense against ZIKV would be to vaccinate the highly susceptible target population, especially pregnant women. Along those lines, several vaccine candidates including purified inactivated virus (PIV), live attenuated virus (LAV), virus like particles (VLP), DNA, modified RNA, viral vectors and subunit vaccines have been in the pipeline with several advancing to clinical trials. As the primary objective of Zika vaccination is the prevention of vertical transmission of the virus to the unborn fetus, the safety and efficacy requirements for this vaccine remain unique when compared to other diseases. This review will discuss these recent advances in the field of Zika vaccine development. |
| first_indexed | 2024-12-19T19:02:47Z |
| format | Article |
| id | doaj.art-74556958f1dc4df389dd26ab398e7a6d |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-19T19:02:47Z |
| publishDate | 2018-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-74556958f1dc4df389dd26ab398e7a6d2022-12-21T20:09:31ZengMDPI AGViruses1999-49152018-11-01101163110.3390/v10110631v10110631Recent Advances in Zika Virus VaccinesHimanshu Garg0Tugba Mehmetoglu-Gurbuz1Anjali Joshi2Center of Emphasis in Infectious Diseases, Department of Biomedical Science, Texas Tech University Health Sciences Center, El Paso, TX 79905, USACenter of Emphasis in Infectious Diseases, Department of Biomedical Science, Texas Tech University Health Sciences Center, El Paso, TX 79905, USACenter of Emphasis in Infectious Diseases, Department of Biomedical Science, Texas Tech University Health Sciences Center, El Paso, TX 79905, USAThe recent outbreaks of Zika virus (ZIKV) infections and associated microcephaly in newborns has resulted in an unprecedented effort by researchers to target this virus. Significant advances have been made in developing vaccine candidates, treatment strategies and diagnostic assays in a relatively short period of time. Being a preventable disease, the first line of defense against ZIKV would be to vaccinate the highly susceptible target population, especially pregnant women. Along those lines, several vaccine candidates including purified inactivated virus (PIV), live attenuated virus (LAV), virus like particles (VLP), DNA, modified RNA, viral vectors and subunit vaccines have been in the pipeline with several advancing to clinical trials. As the primary objective of Zika vaccination is the prevention of vertical transmission of the virus to the unborn fetus, the safety and efficacy requirements for this vaccine remain unique when compared to other diseases. This review will discuss these recent advances in the field of Zika vaccine development.https://www.mdpi.com/1999-4915/10/11/631Zika virusflavivirusesvaccinesvirus like particlesclinical trialsZIKV |
| spellingShingle | Himanshu Garg Tugba Mehmetoglu-Gurbuz Anjali Joshi Recent Advances in Zika Virus Vaccines Viruses Zika virus flaviviruses vaccines virus like particles clinical trials ZIKV |
| title | Recent Advances in Zika Virus Vaccines |
| title_full | Recent Advances in Zika Virus Vaccines |
| title_fullStr | Recent Advances in Zika Virus Vaccines |
| title_full_unstemmed | Recent Advances in Zika Virus Vaccines |
| title_short | Recent Advances in Zika Virus Vaccines |
| title_sort | recent advances in zika virus vaccines |
| topic | Zika virus flaviviruses vaccines virus like particles clinical trials ZIKV |
| url | https://www.mdpi.com/1999-4915/10/11/631 |
| work_keys_str_mv | AT himanshugarg recentadvancesinzikavirusvaccines AT tugbamehmetoglugurbuz recentadvancesinzikavirusvaccines AT anjalijoshi recentadvancesinzikavirusvaccines |