Effectiveness of 23-Valent Pneumococcal Polysaccharide Vaccine against Invasive Pneumococcal Disease in Adults, Japan, 2013–2017
The decline in the proportion of pneumococcal conjugate vaccine (PCV)–covered serotypes among adult invasive pneumococcal disease (IPD) patients might change the overall effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPSV23) because its effectiveness differs according to serotyp...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2020-10-01
|
| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/26/10/19-1531_article |
| _version_ | 1830477197646757888 |
|---|---|
| author | Reiko Shimbashi Motoi Suzuki Bin Chang Hiroshi Watanabe Yoshinari Tanabe Koji Kuronuma Kengo Oshima Takaya Maruyama Hiroaki Takeda Kei Kasahara Jiro Fujita Junichiro Nishi Tetsuya Kubota Keiko Tanaka-Taya Tamano Matsui Tomimasa Sunagawa Kazunori Oishi |
| author_facet | Reiko Shimbashi Motoi Suzuki Bin Chang Hiroshi Watanabe Yoshinari Tanabe Koji Kuronuma Kengo Oshima Takaya Maruyama Hiroaki Takeda Kei Kasahara Jiro Fujita Junichiro Nishi Tetsuya Kubota Keiko Tanaka-Taya Tamano Matsui Tomimasa Sunagawa Kazunori Oishi |
| author_sort | Reiko Shimbashi |
| collection | DOAJ |
| description | The decline in the proportion of pneumococcal conjugate vaccine (PCV)–covered serotypes among adult invasive pneumococcal disease (IPD) patients might change the overall effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPSV23) because its effectiveness differs according to serotype. Using the indirect cohort method, we calculated the effectiveness of PPSV23 against IPD among adults in Japan to assess the impact of the national pediatric PCV program. Clinical and epidemiologic information and pneumococcal isolates were collected from IPD patients >20 years of age through enhanced IPD surveillance during April 2013–December 2017. Adjusted effectiveness against PPSV23-serotype IPD was 42.2%. Despite a substantial decline in the proportion of 13-valent PCV serotypes during the study period (45% to 31%), the change in effectiveness for PPSV23-serotype IPD was limited (47.1% to 39.3%) and only marginal in the elderly population (39.9% to 39.4%). The pediatric PCV program had limited impact on PPSV23 effectiveness against IPD in adults. |
| first_indexed | 2024-12-21T16:09:01Z |
| format | Article |
| id | doaj.art-745611c55d59446f9658352c071f9642 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-21T16:09:01Z |
| publishDate | 2020-10-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-745611c55d59446f9658352c071f96422022-12-21T18:57:50ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592020-10-0126102378238610.3201/eid2610.191531Effectiveness of 23-Valent Pneumococcal Polysaccharide Vaccine against Invasive Pneumococcal Disease in Adults, Japan, 2013–2017Reiko ShimbashiMotoi SuzukiBin ChangHiroshi WatanabeYoshinari TanabeKoji KuronumaKengo OshimaTakaya MaruyamaHiroaki TakedaKei KasaharaJiro FujitaJunichiro NishiTetsuya KubotaKeiko Tanaka-TayaTamano MatsuiTomimasa SunagawaKazunori OishiThe decline in the proportion of pneumococcal conjugate vaccine (PCV)–covered serotypes among adult invasive pneumococcal disease (IPD) patients might change the overall effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPSV23) because its effectiveness differs according to serotype. Using the indirect cohort method, we calculated the effectiveness of PPSV23 against IPD among adults in Japan to assess the impact of the national pediatric PCV program. Clinical and epidemiologic information and pneumococcal isolates were collected from IPD patients >20 years of age through enhanced IPD surveillance during April 2013–December 2017. Adjusted effectiveness against PPSV23-serotype IPD was 42.2%. Despite a substantial decline in the proportion of 13-valent PCV serotypes during the study period (45% to 31%), the change in effectiveness for PPSV23-serotype IPD was limited (47.1% to 39.3%) and only marginal in the elderly population (39.9% to 39.4%). The pediatric PCV program had limited impact on PPSV23 effectiveness against IPD in adults.https://wwwnc.cdc.gov/eid/article/26/10/19-1531_articlePPSV2323-valent pneumococcal polysaccharide vaccineIPDinvasive pneumococcal diseasevaccine effectivenessindirect cohort method |
| spellingShingle | Reiko Shimbashi Motoi Suzuki Bin Chang Hiroshi Watanabe Yoshinari Tanabe Koji Kuronuma Kengo Oshima Takaya Maruyama Hiroaki Takeda Kei Kasahara Jiro Fujita Junichiro Nishi Tetsuya Kubota Keiko Tanaka-Taya Tamano Matsui Tomimasa Sunagawa Kazunori Oishi Effectiveness of 23-Valent Pneumococcal Polysaccharide Vaccine against Invasive Pneumococcal Disease in Adults, Japan, 2013–2017 Emerging Infectious Diseases PPSV23 23-valent pneumococcal polysaccharide vaccine IPD invasive pneumococcal disease vaccine effectiveness indirect cohort method |
| title | Effectiveness of 23-Valent Pneumococcal Polysaccharide Vaccine against Invasive Pneumococcal Disease in Adults, Japan, 2013–2017 |
| title_full | Effectiveness of 23-Valent Pneumococcal Polysaccharide Vaccine against Invasive Pneumococcal Disease in Adults, Japan, 2013–2017 |
| title_fullStr | Effectiveness of 23-Valent Pneumococcal Polysaccharide Vaccine against Invasive Pneumococcal Disease in Adults, Japan, 2013–2017 |
| title_full_unstemmed | Effectiveness of 23-Valent Pneumococcal Polysaccharide Vaccine against Invasive Pneumococcal Disease in Adults, Japan, 2013–2017 |
| title_short | Effectiveness of 23-Valent Pneumococcal Polysaccharide Vaccine against Invasive Pneumococcal Disease in Adults, Japan, 2013–2017 |
| title_sort | effectiveness of 23 valent pneumococcal polysaccharide vaccine against invasive pneumococcal disease in adults japan 2013 2017 |
| topic | PPSV23 23-valent pneumococcal polysaccharide vaccine IPD invasive pneumococcal disease vaccine effectiveness indirect cohort method |
| url | https://wwwnc.cdc.gov/eid/article/26/10/19-1531_article |
| work_keys_str_mv | AT reikoshimbashi effectivenessof23valentpneumococcalpolysaccharidevaccineagainstinvasivepneumococcaldiseaseinadultsjapan20132017 AT motoisuzuki effectivenessof23valentpneumococcalpolysaccharidevaccineagainstinvasivepneumococcaldiseaseinadultsjapan20132017 AT binchang effectivenessof23valentpneumococcalpolysaccharidevaccineagainstinvasivepneumococcaldiseaseinadultsjapan20132017 AT hiroshiwatanabe effectivenessof23valentpneumococcalpolysaccharidevaccineagainstinvasivepneumococcaldiseaseinadultsjapan20132017 AT yoshinaritanabe effectivenessof23valentpneumococcalpolysaccharidevaccineagainstinvasivepneumococcaldiseaseinadultsjapan20132017 AT kojikuronuma effectivenessof23valentpneumococcalpolysaccharidevaccineagainstinvasivepneumococcaldiseaseinadultsjapan20132017 AT kengooshima effectivenessof23valentpneumococcalpolysaccharidevaccineagainstinvasivepneumococcaldiseaseinadultsjapan20132017 AT takayamaruyama effectivenessof23valentpneumococcalpolysaccharidevaccineagainstinvasivepneumococcaldiseaseinadultsjapan20132017 AT hiroakitakeda effectivenessof23valentpneumococcalpolysaccharidevaccineagainstinvasivepneumococcaldiseaseinadultsjapan20132017 AT keikasahara effectivenessof23valentpneumococcalpolysaccharidevaccineagainstinvasivepneumococcaldiseaseinadultsjapan20132017 AT jirofujita effectivenessof23valentpneumococcalpolysaccharidevaccineagainstinvasivepneumococcaldiseaseinadultsjapan20132017 AT junichironishi effectivenessof23valentpneumococcalpolysaccharidevaccineagainstinvasivepneumococcaldiseaseinadultsjapan20132017 AT tetsuyakubota effectivenessof23valentpneumococcalpolysaccharidevaccineagainstinvasivepneumococcaldiseaseinadultsjapan20132017 AT keikotanakataya effectivenessof23valentpneumococcalpolysaccharidevaccineagainstinvasivepneumococcaldiseaseinadultsjapan20132017 AT tamanomatsui effectivenessof23valentpneumococcalpolysaccharidevaccineagainstinvasivepneumococcaldiseaseinadultsjapan20132017 AT tomimasasunagawa effectivenessof23valentpneumococcalpolysaccharidevaccineagainstinvasivepneumococcaldiseaseinadultsjapan20132017 AT kazunorioishi effectivenessof23valentpneumococcalpolysaccharidevaccineagainstinvasivepneumococcaldiseaseinadultsjapan20132017 |