Disease modelling in human organoids
The past decade has seen an explosion in the field of in vitro disease modelling, in particular the development of organoids. These self-organizing tissues derived from stem cells provide a unique system to examine mechanisms ranging from organ development to homeostasis and disease. Because organoi...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Company of Biologists
2019-07-01
|
| Series: | Disease Models & Mechanisms |
| Subjects: | |
| Online Access: | http://dmm.biologists.org/content/12/7/dmm039347 |
| _version_ | 1819159586388574208 |
|---|---|
| author | Madeline A. Lancaster Meritxell Huch |
| author_facet | Madeline A. Lancaster Meritxell Huch |
| author_sort | Madeline A. Lancaster |
| collection | DOAJ |
| description | The past decade has seen an explosion in the field of in vitro disease modelling, in particular the development of organoids. These self-organizing tissues derived from stem cells provide a unique system to examine mechanisms ranging from organ development to homeostasis and disease. Because organoids develop according to intrinsic developmental programmes, the resultant tissue morphology recapitulates organ architecture with remarkable fidelity. Furthermore, the fact that these tissues can be derived from human progenitors allows for the study of uniquely human processes and disorders. This article and accompanying poster highlight the currently available methods, particularly those aimed at modelling human biology, and provide an overview of their capabilities and limitations. We also speculate on possible future technological advances that have the potential for great strides in both disease modelling and future regenerative strategies. |
| first_indexed | 2024-12-22T16:42:54Z |
| format | Article |
| id | doaj.art-74570215f6924f2f87fdfe07e91c8691 |
| institution | Directory Open Access Journal |
| issn | 1754-8403 1754-8411 |
| language | English |
| last_indexed | 2024-12-22T16:42:54Z |
| publishDate | 2019-07-01 |
| publisher | The Company of Biologists |
| record_format | Article |
| series | Disease Models & Mechanisms |
| spelling | doaj.art-74570215f6924f2f87fdfe07e91c86912022-12-21T18:19:49ZengThe Company of BiologistsDisease Models & Mechanisms1754-84031754-84112019-07-0112710.1242/dmm.039347039347Disease modelling in human organoidsMadeline A. Lancaster0Meritxell Huch1 MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge CB2 0QH, UK The Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK The past decade has seen an explosion in the field of in vitro disease modelling, in particular the development of organoids. These self-organizing tissues derived from stem cells provide a unique system to examine mechanisms ranging from organ development to homeostasis and disease. Because organoids develop according to intrinsic developmental programmes, the resultant tissue morphology recapitulates organ architecture with remarkable fidelity. Furthermore, the fact that these tissues can be derived from human progenitors allows for the study of uniquely human processes and disorders. This article and accompanying poster highlight the currently available methods, particularly those aimed at modelling human biology, and provide an overview of their capabilities and limitations. We also speculate on possible future technological advances that have the potential for great strides in both disease modelling and future regenerative strategies.http://dmm.biologists.org/content/12/7/dmm039347Stem cellsEmbryonic developmentRegenerative medicineIn vitro |
| spellingShingle | Madeline A. Lancaster Meritxell Huch Disease modelling in human organoids Disease Models & Mechanisms Stem cells Embryonic development Regenerative medicine In vitro |
| title | Disease modelling in human organoids |
| title_full | Disease modelling in human organoids |
| title_fullStr | Disease modelling in human organoids |
| title_full_unstemmed | Disease modelling in human organoids |
| title_short | Disease modelling in human organoids |
| title_sort | disease modelling in human organoids |
| topic | Stem cells Embryonic development Regenerative medicine In vitro |
| url | http://dmm.biologists.org/content/12/7/dmm039347 |
| work_keys_str_mv | AT madelinealancaster diseasemodellinginhumanorganoids AT meritxellhuch diseasemodellinginhumanorganoids |