PSTPIP2 regulates synovial macrophages polarization and dynamics via ERβ in the joint microenvironment

PSTPIP2 regulates synovial macrophages polarization and dynamics via ERβ in the joint microenvironment

Abstract Background The cytoskeletal protein, PSTPIP2, is associated with inflammation and is predominantly expressed in macrophages. Previous data have shown that PSTPIP2 inhibits articular bone damage in arthritic rats. The aim of this study is to explore the molecular mechanism of PSTPIP2’s resis...

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Bibliographic Details
Main Authors: Yao Yao, Xiaoyu Cai, Meng Zhang, Xiao Zhang, Fujia Ren, Yan Zheng, Weidong Fei, Mengdan Zhao, Caihong Zheng
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Arthritis Research & Therapy
Subjects:
Synovial macrophages
PSTPIP2
Rheumatoid arthritis
Polarization
Dynamics
Estrogen receptor
Online Access:https://doi.org/10.1186/s13075-022-02939-y

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