Prevalence and Genotypes of Hepatitis C Infection Among Hemodialysis Patients in Bushehr, Iran
Objectives: To investigate the prevalence, genotype distribution, and risk factors of hepatitis C virus (HCV) infection among patients undergoing regular hemodialysis in Bushehr province in southern Iran. Methods: All chronic hemodialysis patients from the cities of Dashtestan, Genaveh, and Bushehr...
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| Format: | Article |
| Language: | English |
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Oman Medical Specialty Board
2023-03-01
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| Series: | Oman Medical Journal |
| Subjects: | |
| Online Access: | https://omjournal.org/articleDetails.aspx?coType=1&aId=3363 |
| _version_ | 1797846162750832640 |
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| author | Reza Taherkhani Fatemeh Farshadpour Reza Asayesh |
| author_facet | Reza Taherkhani Fatemeh Farshadpour Reza Asayesh |
| author_sort | Reza Taherkhani |
| collection | DOAJ |
| description | Objectives: To investigate the prevalence, genotype distribution, and risk factors of hepatitis C virus (HCV) infection among patients undergoing regular hemodialysis in Bushehr province in southern Iran. Methods: All chronic hemodialysis patients from the cities of Dashtestan, Genaveh, and Bushehr participated in this study. Enzyme-linked immunosorbent assay was used to detect anti-HCV antibodies. Molecular detection of HCV infection was performed by semi-nested reverse transcription polymerase chain reaction assay, targeting 5’ untranslated region and core region of the genome, and sequencing. Results: Of 279 hemodialysis patients, 15 (5.4%) were positive for anti-HCV antibodies, and two (0.7%) patients had HCV viremia with genotype 3a. The hemodialysis patients had a significantly higher seroprevalence of HCV than the control group (p =0.007). Patients with Arab ethnicity had significantly higher anti-HCV seroprevalence compared to those with Fars ethnicity (p =0.026). Anti-HCV seropositivity was not statistically associated with the patients’ sex, age group, place of residence, level of education, duration of hemodialysis, or history of blood transfusion. Conclusions: Considering the high seroprevalence of HCV in hemodialysis patients, regular screening of these patients for HCV infection and prompt treatment of those found infected are recommended. |
| first_indexed | 2024-04-09T17:50:28Z |
| format | Article |
| id | doaj.art-745990b86fb947739d90953bfd2104e0 |
| institution | Directory Open Access Journal |
| issn | 1999-768X 2070-5204 |
| language | English |
| last_indexed | 2024-04-09T17:50:28Z |
| publishDate | 2023-03-01 |
| publisher | Oman Medical Specialty Board |
| record_format | Article |
| series | Oman Medical Journal |
| spelling | doaj.art-745990b86fb947739d90953bfd2104e02023-04-16T07:10:54ZengOman Medical Specialty BoardOman Medical Journal1999-768X2070-52042023-03-01382e481e48110.5001/omj.2023.60Prevalence and Genotypes of Hepatitis C Infection Among Hemodialysis Patients in Bushehr, IranReza Taherkhani0Fatemeh Farshadpour1Reza Asayesh2Department of Virology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, IranDepartment of Virology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, IranDepartment of Virology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, IranObjectives: To investigate the prevalence, genotype distribution, and risk factors of hepatitis C virus (HCV) infection among patients undergoing regular hemodialysis in Bushehr province in southern Iran. Methods: All chronic hemodialysis patients from the cities of Dashtestan, Genaveh, and Bushehr participated in this study. Enzyme-linked immunosorbent assay was used to detect anti-HCV antibodies. Molecular detection of HCV infection was performed by semi-nested reverse transcription polymerase chain reaction assay, targeting 5’ untranslated region and core region of the genome, and sequencing. Results: Of 279 hemodialysis patients, 15 (5.4%) were positive for anti-HCV antibodies, and two (0.7%) patients had HCV viremia with genotype 3a. The hemodialysis patients had a significantly higher seroprevalence of HCV than the control group (p =0.007). Patients with Arab ethnicity had significantly higher anti-HCV seroprevalence compared to those with Fars ethnicity (p =0.026). Anti-HCV seropositivity was not statistically associated with the patients’ sex, age group, place of residence, level of education, duration of hemodialysis, or history of blood transfusion. Conclusions: Considering the high seroprevalence of HCV in hemodialysis patients, regular screening of these patients for HCV infection and prompt treatment of those found infected are recommended.https://omjournal.org/articleDetails.aspx?coType=1&aId=3363hepatitis c virushemodialysisprevalencegenotyperisk factorsiran |
| spellingShingle | Reza Taherkhani Fatemeh Farshadpour Reza Asayesh Prevalence and Genotypes of Hepatitis C Infection Among Hemodialysis Patients in Bushehr, Iran Oman Medical Journal hepatitis c virus hemodialysis prevalence genotype risk factors iran |
| title | Prevalence and Genotypes of Hepatitis C Infection Among Hemodialysis Patients in Bushehr, Iran |
| title_full | Prevalence and Genotypes of Hepatitis C Infection Among Hemodialysis Patients in Bushehr, Iran |
| title_fullStr | Prevalence and Genotypes of Hepatitis C Infection Among Hemodialysis Patients in Bushehr, Iran |
| title_full_unstemmed | Prevalence and Genotypes of Hepatitis C Infection Among Hemodialysis Patients in Bushehr, Iran |
| title_short | Prevalence and Genotypes of Hepatitis C Infection Among Hemodialysis Patients in Bushehr, Iran |
| title_sort | prevalence and genotypes of hepatitis c infection among hemodialysis patients in bushehr iran |
| topic | hepatitis c virus hemodialysis prevalence genotype risk factors iran |
| url | https://omjournal.org/articleDetails.aspx?coType=1&aId=3363 |
| work_keys_str_mv | AT rezataherkhani prevalenceandgenotypesofhepatitiscinfectionamonghemodialysispatientsinbushehriran AT fatemehfarshadpour prevalenceandgenotypesofhepatitiscinfectionamonghemodialysispatientsinbushehriran AT rezaasayesh prevalenceandgenotypesofhepatitiscinfectionamonghemodialysispatientsinbushehriran |