Nighttime mean arterial pressure is associated with left ventricular hypertrophy in white‐coat hypertension
Abstract White‐coat hypertension (WCH) is associated with increased cardiovascular risks. To investigate the relationship between WCH and left ventricular hypertrophy (LVH), the authors recruited 706 participants who underwent anthropometric measurements, blood laboratory analysis, 24h ambulatory bl...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-08-01
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| Series: | The Journal of Clinical Hypertension |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jch.14530 |
| _version_ | 1797645236448526336 |
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| author | Xiangyu Yang Yuan Yuan Qiling Gou Runyu Ye Xinran Li Jiangbo Li Jun Ma Yanan Li Xiaoping Chen |
| author_facet | Xiangyu Yang Yuan Yuan Qiling Gou Runyu Ye Xinran Li Jiangbo Li Jun Ma Yanan Li Xiaoping Chen |
| author_sort | Xiangyu Yang |
| collection | DOAJ |
| description | Abstract White‐coat hypertension (WCH) is associated with increased cardiovascular risks. To investigate the relationship between WCH and left ventricular hypertrophy (LVH), the authors recruited 706 participants who underwent anthropometric measurements, blood laboratory analysis, 24h ambulatory blood pressure monitoring (ABPM), and echocardiography. The authors defined WCH as elevated office BP but normal ABPM over 24h, daytime, and nighttime periods. The authors compared the proportion of LVH between the true normotension (NT) and the WCH population, and further assessed the associations between BP indexes and LVH in the two groups, respectively. The proportion of LVH was significantly higher in the WCH group than in NT participants (19.70% vs. 13.12%, P = .036). In the NT group, 24h SBP, 24h PP, daytime SBP, daytime PP and SD of nighttime SBP were associated with LVH after adjustment for demographic and blood biochemical data (all P < .05). In the WCH population, LVH was associated with 24h SBP, nighttime SBP, nighttime MAP, and office SBP after adjustment (all P < .05). However, on forward logistic regression analysis with all the BP indexes listed above, only 24h SBP (OR = 1.057, 1.017–1.098, P < .001) in the NT group, and nighttime MAP (OR = 1.114, 1.005–1.235, P < .05) and office SBP (OR = 1.067, 1.019–1.117, P < .001) in the WCH group were still significantly associated with LVH. Our study suggests that the proportion of LVH is higher in WCH patients than in the NT population. Furthermore, elevated nighttime MAP and office SBP may play critical roles in the development of LVH in the WCH population. |
| first_indexed | 2024-03-11T14:43:25Z |
| format | Article |
| id | doaj.art-745bd87cb69f478fbcbcf4af1b69b5e1 |
| institution | Directory Open Access Journal |
| issn | 1524-6175 1751-7176 |
| language | English |
| last_indexed | 2024-03-11T14:43:25Z |
| publishDate | 2022-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj.art-745bd87cb69f478fbcbcf4af1b69b5e12023-10-30T13:26:05ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762022-08-012481035104310.1111/jch.14530Nighttime mean arterial pressure is associated with left ventricular hypertrophy in white‐coat hypertensionXiangyu Yang0Yuan Yuan1Qiling Gou2Runyu Ye3Xinran Li4Jiangbo Li5Jun Ma6Yanan Li7Xiaoping Chen8Department of Cardiology West China Hospital Sichuan University Chengdu ChinaDepartment of Cardiology West China Hospital Sichuan University Chengdu ChinaDepartment of Cardiology Shanxi Provincial People's Hospital Xi'an ChinaDepartment of Cardiology West China Hospital Sichuan University Chengdu ChinaDepartment of Cardiology West China Hospital Sichuan University Chengdu ChinaDepartment of Cardiology West China Hospital Sichuan University Chengdu ChinaDepartment of Cardiology West China Hospital Sichuan University Chengdu ChinaDepartment of Cardiology West China Hospital Sichuan University Chengdu ChinaDepartment of Cardiology West China Hospital Sichuan University Chengdu ChinaAbstract White‐coat hypertension (WCH) is associated with increased cardiovascular risks. To investigate the relationship between WCH and left ventricular hypertrophy (LVH), the authors recruited 706 participants who underwent anthropometric measurements, blood laboratory analysis, 24h ambulatory blood pressure monitoring (ABPM), and echocardiography. The authors defined WCH as elevated office BP but normal ABPM over 24h, daytime, and nighttime periods. The authors compared the proportion of LVH between the true normotension (NT) and the WCH population, and further assessed the associations between BP indexes and LVH in the two groups, respectively. The proportion of LVH was significantly higher in the WCH group than in NT participants (19.70% vs. 13.12%, P = .036). In the NT group, 24h SBP, 24h PP, daytime SBP, daytime PP and SD of nighttime SBP were associated with LVH after adjustment for demographic and blood biochemical data (all P < .05). In the WCH population, LVH was associated with 24h SBP, nighttime SBP, nighttime MAP, and office SBP after adjustment (all P < .05). However, on forward logistic regression analysis with all the BP indexes listed above, only 24h SBP (OR = 1.057, 1.017–1.098, P < .001) in the NT group, and nighttime MAP (OR = 1.114, 1.005–1.235, P < .05) and office SBP (OR = 1.067, 1.019–1.117, P < .001) in the WCH group were still significantly associated with LVH. Our study suggests that the proportion of LVH is higher in WCH patients than in the NT population. Furthermore, elevated nighttime MAP and office SBP may play critical roles in the development of LVH in the WCH population.https://doi.org/10.1111/jch.14530ambulatory blood pressure monitoringechocardiographyleft ventricular hypertrophynighttime blood pressurewhite‐coat hypertension |
| spellingShingle | Xiangyu Yang Yuan Yuan Qiling Gou Runyu Ye Xinran Li Jiangbo Li Jun Ma Yanan Li Xiaoping Chen Nighttime mean arterial pressure is associated with left ventricular hypertrophy in white‐coat hypertension The Journal of Clinical Hypertension ambulatory blood pressure monitoring echocardiography left ventricular hypertrophy nighttime blood pressure white‐coat hypertension |
| title | Nighttime mean arterial pressure is associated with left ventricular hypertrophy in white‐coat hypertension |
| title_full | Nighttime mean arterial pressure is associated with left ventricular hypertrophy in white‐coat hypertension |
| title_fullStr | Nighttime mean arterial pressure is associated with left ventricular hypertrophy in white‐coat hypertension |
| title_full_unstemmed | Nighttime mean arterial pressure is associated with left ventricular hypertrophy in white‐coat hypertension |
| title_short | Nighttime mean arterial pressure is associated with left ventricular hypertrophy in white‐coat hypertension |
| title_sort | nighttime mean arterial pressure is associated with left ventricular hypertrophy in white coat hypertension |
| topic | ambulatory blood pressure monitoring echocardiography left ventricular hypertrophy nighttime blood pressure white‐coat hypertension |
| url | https://doi.org/10.1111/jch.14530 |
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