Degradation‐Resistant Hypoxia Inducible Factor‐2α in Murine Osteocytes Promotes a High Bone Mass Phenotype

ABSTRACT Molecular oxygen levels vary during development and disease. Adaptations to decreased oxygen bioavailability (hypoxia) are mediated by hypoxia‐inducible factor (HIF) transcription factors. HIFs are composed of an oxygen‐dependent α subunit (HIF‐α), of which there are two transcriptionally a...

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Bibliographic Details
Main Authors: Sarah V. Mendoza, Deepa K. Murugesh, Blaine A. Christiansen, Zoe O. Genetos, Gabriela G. Loots, Damian C. Genetos, Clare E. Yellowley
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:JBMR Plus
Subjects:
Online Access:https://doi.org/10.1002/jbm4.10724