Respiratory patterns and baroreflex function in heart failure
Abstract Little is known on the effects of respiratory patterns on baroreflex function in heart failure (HF). Patients with HF (n = 30, age 61.6 ± 10 years, mean ± SD) and healthy controls (CNT, n = 10, age 58.9 ± 5.6 years) having their R–R interval (RRI, EKG), systolic arterial blood pressure (SBP...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-29271-y |
| _version_ | 1828035259116027904 |
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| author | Alberto Radaelli Giuseppe Mancia Giulia Balestri Daniela Bonfanti Paolo Castiglioni |
| author_facet | Alberto Radaelli Giuseppe Mancia Giulia Balestri Daniela Bonfanti Paolo Castiglioni |
| author_sort | Alberto Radaelli |
| collection | DOAJ |
| description | Abstract Little is known on the effects of respiratory patterns on baroreflex function in heart failure (HF). Patients with HF (n = 30, age 61.6 ± 10 years, mean ± SD) and healthy controls (CNT, n = 10, age 58.9 ± 5.6 years) having their R–R interval (RRI, EKG), systolic arterial blood pressure (SBP, Finapres) and respiratory signal (RSP, Respitrace) monitored, were subjected to three recording sessions: free-breathing, fast- (≥ 12 bpm) and slow- (6 bpm) paced breathing. Baroreflex sensitivity (BRS) and power spectra of RRI, SBP, and RSP signals were calculated. During free-breathing, compared to CNT, HF patients showed a significantly greater modulation of respiratory volumes in the very-low-frequency (< 0.04 Hz) range and their BRS was not significantly different from that of CNT. During fast-paced breathing, when very-low-frequency modulations of respiration were reduced, BRS of HF patients was significantly lower than that of CNT and lower than during free breathing. During slow-paced breathing, BRS became again significantly higher than during fast breathing. In conclusion: (1) in free-breathing HF patients is present a greater modulation of respiratory volumes in the very-low-frequency range; (2) in HF patients modulation of respiration in the very-low and low frequency (around 0.1 Hz) ranges contributes to preserve baroreflex-mediated control of heart rate. |
| first_indexed | 2024-04-10T15:45:22Z |
| format | Article |
| id | doaj.art-746061389b424e9dbe0b2fa916090cb1 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-10T15:45:22Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-746061389b424e9dbe0b2fa916090cb12023-02-12T12:10:28ZengNature PortfolioScientific Reports2045-23222023-02-0113111410.1038/s41598-023-29271-yRespiratory patterns and baroreflex function in heart failureAlberto Radaelli0Giuseppe Mancia1Giulia Balestri2Daniela Bonfanti3Paolo Castiglioni4Division of Cardiac Rehabilitation, Fondazione IRCCS San Gerardo dei TintoriUniversity of Milano-BicoccaDivision of Cardiac Rehabilitation, Fondazione IRCCS San Gerardo dei TintoriDivision of Cardiac Rehabilitation, Fondazione IRCCS San Gerardo dei TintoriLaboratory of Movement Analysis and Bioengineering of Rehabilitation (Lamobir), IRCCS Fondazione Don Carlo Gnocchi ONLUSAbstract Little is known on the effects of respiratory patterns on baroreflex function in heart failure (HF). Patients with HF (n = 30, age 61.6 ± 10 years, mean ± SD) and healthy controls (CNT, n = 10, age 58.9 ± 5.6 years) having their R–R interval (RRI, EKG), systolic arterial blood pressure (SBP, Finapres) and respiratory signal (RSP, Respitrace) monitored, were subjected to three recording sessions: free-breathing, fast- (≥ 12 bpm) and slow- (6 bpm) paced breathing. Baroreflex sensitivity (BRS) and power spectra of RRI, SBP, and RSP signals were calculated. During free-breathing, compared to CNT, HF patients showed a significantly greater modulation of respiratory volumes in the very-low-frequency (< 0.04 Hz) range and their BRS was not significantly different from that of CNT. During fast-paced breathing, when very-low-frequency modulations of respiration were reduced, BRS of HF patients was significantly lower than that of CNT and lower than during free breathing. During slow-paced breathing, BRS became again significantly higher than during fast breathing. In conclusion: (1) in free-breathing HF patients is present a greater modulation of respiratory volumes in the very-low-frequency range; (2) in HF patients modulation of respiration in the very-low and low frequency (around 0.1 Hz) ranges contributes to preserve baroreflex-mediated control of heart rate.https://doi.org/10.1038/s41598-023-29271-y |
| spellingShingle | Alberto Radaelli Giuseppe Mancia Giulia Balestri Daniela Bonfanti Paolo Castiglioni Respiratory patterns and baroreflex function in heart failure Scientific Reports |
| title | Respiratory patterns and baroreflex function in heart failure |
| title_full | Respiratory patterns and baroreflex function in heart failure |
| title_fullStr | Respiratory patterns and baroreflex function in heart failure |
| title_full_unstemmed | Respiratory patterns and baroreflex function in heart failure |
| title_short | Respiratory patterns and baroreflex function in heart failure |
| title_sort | respiratory patterns and baroreflex function in heart failure |
| url | https://doi.org/10.1038/s41598-023-29271-y |
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