A comparison of endothelial cell growth on commercial coronary stents with and without laser surface texturing
Complete endothelialisation of coronary stents is an important determinant of future thrombotic complications following coronary stenting. Stent surface texture is an important factor that influences endothelial cell growth. With the emergence of second and third generation coronary stents, is limit...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024024563 |
| _version_ | 1797259868332097536 |
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| author | Nazanin Mirhosseini Lin Li Zhu Liu Mamas Mamas Douglas Fraser Tao Wang |
| author_facet | Nazanin Mirhosseini Lin Li Zhu Liu Mamas Mamas Douglas Fraser Tao Wang |
| author_sort | Nazanin Mirhosseini |
| collection | DOAJ |
| description | Complete endothelialisation of coronary stents is an important determinant of future thrombotic complications following coronary stenting. Stent surface texture is an important factor that influences endothelial cell growth. With the emergence of second and third generation coronary stents, is limited comparative data describing endothelial cell growth in contemporary stent platforms, and limited data available on approaches used to rapidly modify the surfaces of commercial coronary stents to improve endothelialisation. In this study we have determined the in vitro proliferation of the primary human coronary artery endothelial cells on the commonly used 4 types of commercial coronary stents and found that the inner surface of BioMatrix drug-eluting stents (DES), after eliminating of the polymer and drug coating, had significantly higher endothelial cell proliferation compared to that of other bare metal stents (BMS): Multi-Link8, Integrity and Omega. The surfaces of the 3 types of BMS which are smooth, displayed similar endothelial cell proliferation, suggesting the importance of surface features in manipulating endothelial cell growth. Laser surface texturing was used to create micro/nano patterns on the stents. The laser treatment has significantly increased endothelial proliferation on the inner surfaces of all 4 types of stents, and Multi-Link8 stents displayed the highest (>100%) improvement. The laser textured BioMatrix stents had the highest absolute number of endothelial cells growth. Our results provided useful information in the endothelialisation potential for the commonly used commercial coronary stents and suggested a potential future application of laser surface bioengineering to coronary stents for better biocompatibility of the device. |
| first_indexed | 2024-03-07T21:53:19Z |
| format | Article |
| id | doaj.art-7460c8335d564e2eb1012a6e13f7f5e5 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T23:16:16Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-7460c8335d564e2eb1012a6e13f7f5e52024-03-17T07:55:28ZengElsevierHeliyon2405-84402024-03-01105e26425A comparison of endothelial cell growth on commercial coronary stents with and without laser surface texturingNazanin Mirhosseini0Lin Li1Zhu Liu2Mamas Mamas3Douglas Fraser4Tao Wang5Engineering Building A, 4th Floor Core 1, Department of Engineering for Sustainability, School of Engineering, Faculty of Science and Engineering, The University of Manchester, Manchester, M13 9PL, UK; Corresponding author.Department of Engineering for Sustainability, School of Engineering, The University of Manchester, Manchester, M13 9PL, UKResearch Centre for Laser Extreme Manufacturing, Ningbo Institute of Materials Engineering and Technology, Chinese Academy of Science, Ningbo, ChinaCardiovascular Research Group, Institute of Science and Technology in Medicine, University of Keele, Stoke-on-Trent, and Royal Stoke Hospital, Stoke-on-Trent, UKManchester Heart Centre, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UKAV Hill Building, Faculty of Biology, Medicine and Health, The University of Manchester, Upper Brook Street, Manchester, M13 9PT, UKComplete endothelialisation of coronary stents is an important determinant of future thrombotic complications following coronary stenting. Stent surface texture is an important factor that influences endothelial cell growth. With the emergence of second and third generation coronary stents, is limited comparative data describing endothelial cell growth in contemporary stent platforms, and limited data available on approaches used to rapidly modify the surfaces of commercial coronary stents to improve endothelialisation. In this study we have determined the in vitro proliferation of the primary human coronary artery endothelial cells on the commonly used 4 types of commercial coronary stents and found that the inner surface of BioMatrix drug-eluting stents (DES), after eliminating of the polymer and drug coating, had significantly higher endothelial cell proliferation compared to that of other bare metal stents (BMS): Multi-Link8, Integrity and Omega. The surfaces of the 3 types of BMS which are smooth, displayed similar endothelial cell proliferation, suggesting the importance of surface features in manipulating endothelial cell growth. Laser surface texturing was used to create micro/nano patterns on the stents. The laser treatment has significantly increased endothelial proliferation on the inner surfaces of all 4 types of stents, and Multi-Link8 stents displayed the highest (>100%) improvement. The laser textured BioMatrix stents had the highest absolute number of endothelial cells growth. Our results provided useful information in the endothelialisation potential for the commonly used commercial coronary stents and suggested a potential future application of laser surface bioengineering to coronary stents for better biocompatibility of the device.http://www.sciencedirect.com/science/article/pii/S2405844024024563BiocompatibilityCell adhesion and proliferationEndothelialisationLaser surface-texturingSurface chemistry |
| spellingShingle | Nazanin Mirhosseini Lin Li Zhu Liu Mamas Mamas Douglas Fraser Tao Wang A comparison of endothelial cell growth on commercial coronary stents with and without laser surface texturing Heliyon Biocompatibility Cell adhesion and proliferation Endothelialisation Laser surface-texturing Surface chemistry |
| title | A comparison of endothelial cell growth on commercial coronary stents with and without laser surface texturing |
| title_full | A comparison of endothelial cell growth on commercial coronary stents with and without laser surface texturing |
| title_fullStr | A comparison of endothelial cell growth on commercial coronary stents with and without laser surface texturing |
| title_full_unstemmed | A comparison of endothelial cell growth on commercial coronary stents with and without laser surface texturing |
| title_short | A comparison of endothelial cell growth on commercial coronary stents with and without laser surface texturing |
| title_sort | comparison of endothelial cell growth on commercial coronary stents with and without laser surface texturing |
| topic | Biocompatibility Cell adhesion and proliferation Endothelialisation Laser surface-texturing Surface chemistry |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024024563 |
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