Pretransplant BK Virus-Specific T-Cell-Mediated Immunity and Serotype Specific Antibodies May Have Utility in Identifying Patients at Risk of BK Virus-Associated Haemorrhagic Cystitis after Allogeneic HSCT

Pretransplant BK Virus-Specific T-Cell-Mediated Immunity and Serotype Specific Antibodies May Have Utility in Identifying Patients at Risk of BK Virus-Associated Haemorrhagic Cystitis after Allogeneic HSCT

BK polyomavirus (BKPyV) persists lifelong in renal and urothelial cells with asymptomatic urinary shedding in healthy individuals. In some immunocompromised persons after transplantation of hematopoietic stem cells (HSCT), the BKPyV high-rate replication is associated with haemorrhagic cystitis (HC)...

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Bibliographic Details
Main Authors: Markéta Šťastná-Marková, Eva Hamšíková, Petr Hainz, Petr Hubáček, Marie Kroutilová, Jitka Kryštofová, Viera Ludvíková, Jan Musil, Pavla Pecherková, Martina Saláková, Vojtěch Šroller, Jan Vydra, Šárka Němečková
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Vaccines
Subjects:
human BK polyomavirus 1 and 4 (BKPyV 1 and 4)
haemorrhagic cystitis
anti/BKPyV IgG
T-cell response
VP1
LTag
Online Access:https://www.mdpi.com/2076-393X/9/11/1226

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https://www.mdpi.com/2076-393X/9/11/1226

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