Langerhans cell histiocytosis in children diagnosed by fine-needle aspiration
Background: Langerhans cell histiocytosis (LCH) is a rare intricate pediatric neoplasm with varied clinical manifestations and multiple treatment modalities. Aim: To study the cytological features of LCH and the differential diagnoses on fine-needle aspiration (FNA). Materials and Methods: FNA was...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Journal of Cytology |
| Subjects: | |
| Online Access: | http://www.jcytol.org/article.asp?issn=0970-9371;year=2015;volume=32;issue=4;spage=244;epage=247;aulast=Handa |
| _version_ | 1818850140180447232 |
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| author | Uma Handa Reetu Kundu Rajpal Singh Punia Harsh Mohan |
| author_facet | Uma Handa Reetu Kundu Rajpal Singh Punia Harsh Mohan |
| author_sort | Uma Handa |
| collection | DOAJ |
| description | Background: Langerhans cell histiocytosis (LCH) is a rare intricate pediatric neoplasm with varied clinical manifestations and multiple treatment modalities.
Aim: To study the cytological features of LCH and the differential diagnoses on fine-needle aspiration (FNA).
Materials and Methods: FNA was performed using a 23-gauge needle fitted to a 10 mL syringe mounted on syringe holder. LCH was diagnosed on FNA smears in seven cases confined to the head and neck region, which included three cases of lymphadenopathy, three cases of scalp swelling, and one case of orbital swelling.
Results: The age of the patients ranged from 25 days to 11 years and male-to-female ratio was 1:1.3. Clinically, the diagnoses suggested were tuberculosis, inflammatory lesion, abscess, and malignancy. The cytologic findings included high cellularity, isolated Langerhans cells (LCs) with prominent nuclear indentation, grooves and abundant vacuolated cytoplasm, multinucleated giant cells, eosinophils, and lymphocytes. Areas of necrosis were noted in one case. Histopathology, along with positive S-100 immunohistochemistry, confirmed the diagnosis of LCH.
Conclusions: LCH is a rare disease occurring predominantly in children and can be diagnosed with ease on FNA cytology by the presence of characteristic Langerhans cells. The S-100 positivity aids in suggesting a diagnosis of LCH. |
| first_indexed | 2024-12-19T06:44:24Z |
| format | Article |
| id | doaj.art-74616b3093c7490cbaaaa23a2d3fd006 |
| institution | Directory Open Access Journal |
| issn | 0970-9371 |
| language | English |
| last_indexed | 2024-12-19T06:44:24Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Cytology |
| spelling | doaj.art-74616b3093c7490cbaaaa23a2d3fd0062022-12-21T20:31:58ZengWolters Kluwer Medknow PublicationsJournal of Cytology0970-93712015-01-0132424424710.4103/0970-9371.171237Langerhans cell histiocytosis in children diagnosed by fine-needle aspirationUma HandaReetu KunduRajpal Singh PuniaHarsh MohanBackground: Langerhans cell histiocytosis (LCH) is a rare intricate pediatric neoplasm with varied clinical manifestations and multiple treatment modalities. Aim: To study the cytological features of LCH and the differential diagnoses on fine-needle aspiration (FNA). Materials and Methods: FNA was performed using a 23-gauge needle fitted to a 10 mL syringe mounted on syringe holder. LCH was diagnosed on FNA smears in seven cases confined to the head and neck region, which included three cases of lymphadenopathy, three cases of scalp swelling, and one case of orbital swelling. Results: The age of the patients ranged from 25 days to 11 years and male-to-female ratio was 1:1.3. Clinically, the diagnoses suggested were tuberculosis, inflammatory lesion, abscess, and malignancy. The cytologic findings included high cellularity, isolated Langerhans cells (LCs) with prominent nuclear indentation, grooves and abundant vacuolated cytoplasm, multinucleated giant cells, eosinophils, and lymphocytes. Areas of necrosis were noted in one case. Histopathology, along with positive S-100 immunohistochemistry, confirmed the diagnosis of LCH. Conclusions: LCH is a rare disease occurring predominantly in children and can be diagnosed with ease on FNA cytology by the presence of characteristic Langerhans cells. The S-100 positivity aids in suggesting a diagnosis of LCH.http://www.jcytol.org/article.asp?issn=0970-9371;year=2015;volume=32;issue=4;spage=244;epage=247;aulast=HandaCytology; fine-needle aspiration (FNA); Langerhans cell histiocytosis (LCH) |
| spellingShingle | Uma Handa Reetu Kundu Rajpal Singh Punia Harsh Mohan Langerhans cell histiocytosis in children diagnosed by fine-needle aspiration Journal of Cytology Cytology; fine-needle aspiration (FNA); Langerhans cell histiocytosis (LCH) |
| title | Langerhans cell histiocytosis in children diagnosed by fine-needle aspiration |
| title_full | Langerhans cell histiocytosis in children diagnosed by fine-needle aspiration |
| title_fullStr | Langerhans cell histiocytosis in children diagnosed by fine-needle aspiration |
| title_full_unstemmed | Langerhans cell histiocytosis in children diagnosed by fine-needle aspiration |
| title_short | Langerhans cell histiocytosis in children diagnosed by fine-needle aspiration |
| title_sort | langerhans cell histiocytosis in children diagnosed by fine needle aspiration |
| topic | Cytology; fine-needle aspiration (FNA); Langerhans cell histiocytosis (LCH) |
| url | http://www.jcytol.org/article.asp?issn=0970-9371;year=2015;volume=32;issue=4;spage=244;epage=247;aulast=Handa |
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