Mechanism and regulation of DNA damage recognition in nucleotide excision repair

Mechanism and regulation of DNA damage recognition in nucleotide excision repair

Abstract Nucleotide excision repair (NER) is a versatile DNA repair pathway, which can remove an extremely broad range of base lesions from the genome. In mammalian global genomic NER, the XPC protein complex initiates the repair reaction by recognizing sites of DNA damage, and this depends on detec...

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Bibliographic Details
Main Authors: Masayuki Kusakabe, Yuki Onishi, Haruto Tada, Fumika Kurihara, Kanako Kusao, Mari Furukawa, Shigenori Iwai, Masayuki Yokoi, Wataru Sakai, Kaoru Sugasawa
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Genes and Environment
Subjects:
Nucleotide excision repair
DNA damage recognition
XPC
TFIIH
XPA
UV-DDB
Online Access:http://link.springer.com/article/10.1186/s41021-019-0119-6

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