Thrombomodulin reduces α-synuclein generation and ameliorates neuropathology in a mouse model of Parkinson’s disease

Thrombomodulin reduces α-synuclein generation and ameliorates neuropathology in a mouse model of Parkinson’s disease

Abstract The neurotoxic α-synuclein (α-syn) oligomers play an important role in the occurrence and development of Parkinson’s disease (PD), but the factors affecting α-syn generation and neurotoxicity remain unclear. We here first found that thrombomodulin (TM) significantly decreased in the plasma...

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Main Authors:	Xiao-yun Niu, Xi-xiu Xie, Hou-zhen Tuo, Cui-ping Lv, Ya-ru Huang, Jie Zhu, Shi-yu Liang, Xiao-yu Du, Cheng-gang Yang, Sheng-jie Hou, Xiao-ying Sun, Ling-jie Li, Fang Cui, Qi-xin Huang, Ying-bo Jia, Yu-jiong Wang, Rui-tian Liu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2024-04-01
Series:	Cell Death Discovery
Online Access:	https://doi.org/10.1038/s41420-024-01939-y

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