The predictive value of the hs-CRP/HDL-C ratio, an inflammation-lipid composite marker, for cardiovascular disease in middle-aged and elderly people: evidence from a large national cohort study
Abstract Background and aims Cardiovascular disease (CVD) is associated with inflammation and abnormal lipid metabolism. However, a single inflammatory index or a single lipid index cannot accurately predict the prognosis of CVD independently because it is prone to be affected by various confounding...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12944-024-02055-7 |
| _version_ | 1797273391983493120 |
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| author | Yu Gao Miyuan Wang Ruiting Wang Jinchi Jiang Yueyao Hu Wei Wang Yong Wang Haijing Li |
| author_facet | Yu Gao Miyuan Wang Ruiting Wang Jinchi Jiang Yueyao Hu Wei Wang Yong Wang Haijing Li |
| author_sort | Yu Gao |
| collection | DOAJ |
| description | Abstract Background and aims Cardiovascular disease (CVD) is associated with inflammation and abnormal lipid metabolism. However, a single inflammatory index or a single lipid index cannot accurately predict the prognosis of CVD independently because it is prone to be affected by various confounding factors. Methods This population-based cohort study included 6,554 participants from the China Health and Retirement Longitudinal Study (CHARLS) to investigate correlations. In the present study, the occurrence of CVD events such as stroke and heart disease was evaluated by considering self-reported diagnoses at the beginning of the study and during wave 4, and a restricted cubic spline model was used to investigate potential nonlinear relationships in addition to multivariate logistic regression models. Stratified analyses were performed to examine how sociodemographic characteristics may influence the results. Results Seven years of follow-up (2011–2018) revealed that 786 people (11.99%) developed CVD. According to the adjusted model, the high-sensitivity C-reactive protein (hs-CRP)-to-high-density lipoprotein cholesterol (HDL-C) ratio is a contributing factor to CVD risk (OR 1.31, 95% CI 1.05–1.64). In addition, a nonlinear relationship was observed between the hs-CRP/HDL-C ratio and the occurrence of new CVD, stroke, or cardiac issues (P overall <0.05, Pnonlinear <0.05). Moreover, noteworthy associations between the hs-CRP/HDL-C ratio and age were detected in the stratified analysis (P = 0.048), indicating that younger participants had more negative effects of a high hs-CRP/HDL-C ratio. Conclusions According to the present cohort study, a high hs-CRP/HDL-C ratio is a significant risk factor for CVD, new stroke, and heart problems. Early intervention in patients with increased hs-CRP/HDL-C ratios may further reduce the incidence of CVD, in addition to focusing on independent lipid markers or independent inflammatory markers. |
| first_indexed | 2024-03-07T14:43:42Z |
| format | Article |
| id | doaj.art-74629b31bc9a4635895435946d165c06 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-03-07T14:43:42Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-74629b31bc9a4635895435946d165c062024-03-05T20:07:48ZengBMCLipids in Health and Disease1476-511X2024-03-0123111110.1186/s12944-024-02055-7The predictive value of the hs-CRP/HDL-C ratio, an inflammation-lipid composite marker, for cardiovascular disease in middle-aged and elderly people: evidence from a large national cohort studyYu Gao0Miyuan Wang1Ruiting Wang2Jinchi Jiang3Yueyao Hu4Wei Wang5Yong Wang6Haijing Li7College of Chinese Medicine, Beijing University of Chinese MedicineSchool of public health, Huazhong University of Science and TechnologyDongzhimen Hospital, Beijing University of Chinese MedicineCollege of Chinese Medicine, Beijing University of Chinese MedicineCollege of Chinese Medicine, Beijing University of Chinese MedicineCollege of Chinese Medicine, Beijing University of Chinese MedicineCollege of Chinese Medicine, Beijing University of Chinese MedicineCollege of Chinese Medicine, Beijing University of Chinese MedicineAbstract Background and aims Cardiovascular disease (CVD) is associated with inflammation and abnormal lipid metabolism. However, a single inflammatory index or a single lipid index cannot accurately predict the prognosis of CVD independently because it is prone to be affected by various confounding factors. Methods This population-based cohort study included 6,554 participants from the China Health and Retirement Longitudinal Study (CHARLS) to investigate correlations. In the present study, the occurrence of CVD events such as stroke and heart disease was evaluated by considering self-reported diagnoses at the beginning of the study and during wave 4, and a restricted cubic spline model was used to investigate potential nonlinear relationships in addition to multivariate logistic regression models. Stratified analyses were performed to examine how sociodemographic characteristics may influence the results. Results Seven years of follow-up (2011–2018) revealed that 786 people (11.99%) developed CVD. According to the adjusted model, the high-sensitivity C-reactive protein (hs-CRP)-to-high-density lipoprotein cholesterol (HDL-C) ratio is a contributing factor to CVD risk (OR 1.31, 95% CI 1.05–1.64). In addition, a nonlinear relationship was observed between the hs-CRP/HDL-C ratio and the occurrence of new CVD, stroke, or cardiac issues (P overall <0.05, Pnonlinear <0.05). Moreover, noteworthy associations between the hs-CRP/HDL-C ratio and age were detected in the stratified analysis (P = 0.048), indicating that younger participants had more negative effects of a high hs-CRP/HDL-C ratio. Conclusions According to the present cohort study, a high hs-CRP/HDL-C ratio is a significant risk factor for CVD, new stroke, and heart problems. Early intervention in patients with increased hs-CRP/HDL-C ratios may further reduce the incidence of CVD, in addition to focusing on independent lipid markers or independent inflammatory markers.https://doi.org/10.1186/s12944-024-02055-7C-reactive proteinHigh-density lipoprotein cholesterolCardiovascular diseaseCohort studyRisk factor |
| spellingShingle | Yu Gao Miyuan Wang Ruiting Wang Jinchi Jiang Yueyao Hu Wei Wang Yong Wang Haijing Li The predictive value of the hs-CRP/HDL-C ratio, an inflammation-lipid composite marker, for cardiovascular disease in middle-aged and elderly people: evidence from a large national cohort study Lipids in Health and Disease C-reactive protein High-density lipoprotein cholesterol Cardiovascular disease Cohort study Risk factor |
| title | The predictive value of the hs-CRP/HDL-C ratio, an inflammation-lipid composite marker, for cardiovascular disease in middle-aged and elderly people: evidence from a large national cohort study |
| title_full | The predictive value of the hs-CRP/HDL-C ratio, an inflammation-lipid composite marker, for cardiovascular disease in middle-aged and elderly people: evidence from a large national cohort study |
| title_fullStr | The predictive value of the hs-CRP/HDL-C ratio, an inflammation-lipid composite marker, for cardiovascular disease in middle-aged and elderly people: evidence from a large national cohort study |
| title_full_unstemmed | The predictive value of the hs-CRP/HDL-C ratio, an inflammation-lipid composite marker, for cardiovascular disease in middle-aged and elderly people: evidence from a large national cohort study |
| title_short | The predictive value of the hs-CRP/HDL-C ratio, an inflammation-lipid composite marker, for cardiovascular disease in middle-aged and elderly people: evidence from a large national cohort study |
| title_sort | predictive value of the hs crp hdl c ratio an inflammation lipid composite marker for cardiovascular disease in middle aged and elderly people evidence from a large national cohort study |
| topic | C-reactive protein High-density lipoprotein cholesterol Cardiovascular disease Cohort study Risk factor |
| url | https://doi.org/10.1186/s12944-024-02055-7 |
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