Blockade of TIM3 relieves immunosuppression through reducing regulatory T cells in head and neck cancer

Blockade of TIM3 relieves immunosuppression through reducing regulatory T cells in head and neck cancer

Abstract Background T-cell immunoglobulin mucin 3 (TIM3) is a negative immune checkpoint and plays a crucial part in tumor-induced immune suppression. However, the mechanism of TIM3 in regulating immunosuppression in head and neck squamous cell carcinoma (HNSCC) was still not quite clear. Methods We...

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Bibliographic Details
Main Authors: Jian-Feng Liu, Lei Wu, Lei-Lei Yang, Wei-Wei Deng, Liang Mao, Hao Wu, Wen-Feng Zhang, Zhi-Jun Sun
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Head and neck cancer
Immunosuppression
Immunotherapy
Immune checkpoint
Tregs
Macrophages
Online Access:http://link.springer.com/article/10.1186/s13046-018-0713-7

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