D-Pinitol Content and Antioxidant and Antidiabetic Activities of Five <i>Bougainvillea spectabilis</i> Willd. Cultivars
Diabetes mellitus is a major challenge for global health, and <i>Bougainvillea spectabilis</i> Willd. (<i>B. spectabilis</i>) is a widely used herbal remedy with diverse cultivars traditionally used for diabetes treatment. However, the comparative efficacy of these cultivars...
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MDPI AG
2023-07-01
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| Online Access: | https://www.mdpi.com/1424-8247/16/7/1008 |
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| author | Fatma Abo-Elghiet Amal H. Ahmed Hanan F. Aly Eman A. Younis Mohamed A. Rabeh Saad Ali Alshehri Khalid S. A. Alshahrani Shaza A. Mohamed |
| author_facet | Fatma Abo-Elghiet Amal H. Ahmed Hanan F. Aly Eman A. Younis Mohamed A. Rabeh Saad Ali Alshehri Khalid S. A. Alshahrani Shaza A. Mohamed |
| author_sort | Fatma Abo-Elghiet |
| collection | DOAJ |
| description | Diabetes mellitus is a major challenge for global health, and <i>Bougainvillea spectabilis</i> Willd. (<i>B. spectabilis</i>) is a widely used herbal remedy with diverse cultivars traditionally used for diabetes treatment. However, the comparative efficacy of these cultivars remains ambiguous. This study aimed to evaluate the D-pinitol content and DPPH radical-scavenging activity of methanolic leaves extracts of five <i>B. spectabilis</i> cultivars. Furthermore, the effects of these cultivars on various parameters, including blood glucose levels, oxidative stress markers, inflammatory cytokines, lipid profiles, liver enzymes, renal function markers, and histopathological changes, were assessed in STZ-induced diabetic rats after one month of oral daily treatment. All tested cultivars demonstrated significant improvements in the measured parameters, albeit to varying extents. Notably, the LOE cultivar, distinguished by its orange bracts, exhibited the highest efficacy, surpassing the effectiveness of glibenclamide, an antidiabetic medication, and displayed the highest concentration of D-pinitol. These findings underscore the importance of carefully selecting the appropriate <i>B. spectabilis</i> cultivar to maximize the antidiabetic efficacy, with a particular emphasis on the correlation between antidiabetic activity and D-pinitol concentrations. |
| first_indexed | 2024-03-11T00:44:53Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-11T00:44:53Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-7463f7dd386a42f6895d286b0dcfda142023-11-18T20:53:05ZengMDPI AGPharmaceuticals1424-82472023-07-01167100810.3390/ph16071008D-Pinitol Content and Antioxidant and Antidiabetic Activities of Five <i>Bougainvillea spectabilis</i> Willd. CultivarsFatma Abo-Elghiet0Amal H. Ahmed1Hanan F. Aly2Eman A. Younis3Mohamed A. Rabeh4Saad Ali Alshehri5Khalid S. A. Alshahrani6Shaza A. Mohamed7Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo 11754, EgyptDepartment of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo 11754, EgyptDepartment of Therapeutic Chemistry, National Research Centre (NRC), El Behouth St., Giza 12311, EgyptDepartment of Therapeutic Chemistry, National Research Centre (NRC), El Behouth St., Giza 12311, EgyptDepartment of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 62521, Saudi ArabiaDepartment of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 62521, Saudi ArabiaCollege of Pharmacy, King Khalid University, Abha 62521, Saudi ArabiaDepartment of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo 11754, EgyptDiabetes mellitus is a major challenge for global health, and <i>Bougainvillea spectabilis</i> Willd. (<i>B. spectabilis</i>) is a widely used herbal remedy with diverse cultivars traditionally used for diabetes treatment. However, the comparative efficacy of these cultivars remains ambiguous. This study aimed to evaluate the D-pinitol content and DPPH radical-scavenging activity of methanolic leaves extracts of five <i>B. spectabilis</i> cultivars. Furthermore, the effects of these cultivars on various parameters, including blood glucose levels, oxidative stress markers, inflammatory cytokines, lipid profiles, liver enzymes, renal function markers, and histopathological changes, were assessed in STZ-induced diabetic rats after one month of oral daily treatment. All tested cultivars demonstrated significant improvements in the measured parameters, albeit to varying extents. Notably, the LOE cultivar, distinguished by its orange bracts, exhibited the highest efficacy, surpassing the effectiveness of glibenclamide, an antidiabetic medication, and displayed the highest concentration of D-pinitol. These findings underscore the importance of carefully selecting the appropriate <i>B. spectabilis</i> cultivar to maximize the antidiabetic efficacy, with a particular emphasis on the correlation between antidiabetic activity and D-pinitol concentrations.https://www.mdpi.com/1424-8247/16/7/1008<i>Bougainvillea spectabilis</i>cultivarsD-pinitolantidiabeticantioxidant |
| spellingShingle | Fatma Abo-Elghiet Amal H. Ahmed Hanan F. Aly Eman A. Younis Mohamed A. Rabeh Saad Ali Alshehri Khalid S. A. Alshahrani Shaza A. Mohamed D-Pinitol Content and Antioxidant and Antidiabetic Activities of Five <i>Bougainvillea spectabilis</i> Willd. Cultivars Pharmaceuticals <i>Bougainvillea spectabilis</i> cultivars D-pinitol antidiabetic antioxidant |
| title | D-Pinitol Content and Antioxidant and Antidiabetic Activities of Five <i>Bougainvillea spectabilis</i> Willd. Cultivars |
| title_full | D-Pinitol Content and Antioxidant and Antidiabetic Activities of Five <i>Bougainvillea spectabilis</i> Willd. Cultivars |
| title_fullStr | D-Pinitol Content and Antioxidant and Antidiabetic Activities of Five <i>Bougainvillea spectabilis</i> Willd. Cultivars |
| title_full_unstemmed | D-Pinitol Content and Antioxidant and Antidiabetic Activities of Five <i>Bougainvillea spectabilis</i> Willd. Cultivars |
| title_short | D-Pinitol Content and Antioxidant and Antidiabetic Activities of Five <i>Bougainvillea spectabilis</i> Willd. Cultivars |
| title_sort | d pinitol content and antioxidant and antidiabetic activities of five i bougainvillea spectabilis i willd cultivars |
| topic | <i>Bougainvillea spectabilis</i> cultivars D-pinitol antidiabetic antioxidant |
| url | https://www.mdpi.com/1424-8247/16/7/1008 |
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