Impulsivity trait mediates the relationship between white matter integrity of prefrontal–striatal circuits and the severity of dependence in alcoholism
BackgroundAlcohol dependence (AD) remains one of the major public health concerns. Impulsivity plays a central role in the transfer from recreational alcohol use to dependence and relapse. White matter dysfunction has been implicated in alcohol addiction behaviors and impulsivity. However, little is...
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.985948/full |
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| author | Fei Wu Ping Dong Guowei Wu Jiahui Deng Zhaojun Ni Xuejiao Gao Peng Li Bing Li Junliang Yuan Hongqiang Sun |
| author_facet | Fei Wu Ping Dong Guowei Wu Jiahui Deng Zhaojun Ni Xuejiao Gao Peng Li Bing Li Junliang Yuan Hongqiang Sun |
| author_sort | Fei Wu |
| collection | DOAJ |
| description | BackgroundAlcohol dependence (AD) remains one of the major public health concerns. Impulsivity plays a central role in the transfer from recreational alcohol use to dependence and relapse. White matter dysfunction has been implicated in alcohol addiction behaviors and impulsivity. However, little is known about the role of systematic striatal structural connections underlying the mechanism of impulsive traits in AD.MethodsIn our study, we used seed-based classification by probabilistic tractography with five target masks of striatal circuits to explore the differences in white matter integrity (fractional anisotropy, FA) in AD male patients (N = 51) and healthy controls (N = 27). We mainly explored the correlation between FA of the striatal circuits and impulsive traits (Barratt Impulsiveness Scale, BIS-11), and the mediation role of impulsivity in white matter integrity and the severity of alcohol dependence.ResultsCompared with healthy controls, AD showed much lower FA in the left and right striatum–supplementary motor area (SMA) and left striatum–amygdala. We also found the decreased FA of right striatum-vlPFC was correlated with higher impulsivity. Besides, the relationship between reduced FA of right striatum-vlPFC and severity of dependence could be mediated by impulsivity.ConclusionIn our study, we found disrupted white matter integrity in systematic striatal circuits in AD and the decreased FA of right striatum-vlPFC was correlated with higher impulsivity in AD. Our main findings provide evidence for reduced white matter integrity of systematic striatal circuits and the underlying mechanisms of impulsivity in male AD individuals. |
| first_indexed | 2024-04-11T13:36:28Z |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-04-11T13:36:28Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-74640e5079fa40b08de1ae738490ceff2022-12-22T04:21:28ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-09-011310.3389/fpsyt.2022.985948985948Impulsivity trait mediates the relationship between white matter integrity of prefrontal–striatal circuits and the severity of dependence in alcoholismFei Wu0Ping Dong1Guowei Wu2Jiahui Deng3Zhaojun Ni4Xuejiao Gao5Peng Li6Bing Li7Junliang Yuan8Hongqiang Sun9Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, ChinaChinese Institute for Brain Research, Beijing, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, ChinaDepartment of Neurology, Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, ChinaBackgroundAlcohol dependence (AD) remains one of the major public health concerns. Impulsivity plays a central role in the transfer from recreational alcohol use to dependence and relapse. White matter dysfunction has been implicated in alcohol addiction behaviors and impulsivity. However, little is known about the role of systematic striatal structural connections underlying the mechanism of impulsive traits in AD.MethodsIn our study, we used seed-based classification by probabilistic tractography with five target masks of striatal circuits to explore the differences in white matter integrity (fractional anisotropy, FA) in AD male patients (N = 51) and healthy controls (N = 27). We mainly explored the correlation between FA of the striatal circuits and impulsive traits (Barratt Impulsiveness Scale, BIS-11), and the mediation role of impulsivity in white matter integrity and the severity of alcohol dependence.ResultsCompared with healthy controls, AD showed much lower FA in the left and right striatum–supplementary motor area (SMA) and left striatum–amygdala. We also found the decreased FA of right striatum-vlPFC was correlated with higher impulsivity. Besides, the relationship between reduced FA of right striatum-vlPFC and severity of dependence could be mediated by impulsivity.ConclusionIn our study, we found disrupted white matter integrity in systematic striatal circuits in AD and the decreased FA of right striatum-vlPFC was correlated with higher impulsivity in AD. Our main findings provide evidence for reduced white matter integrity of systematic striatal circuits and the underlying mechanisms of impulsivity in male AD individuals.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.985948/fullalcohol dependenceimpulsivitysystematic striatal circuitsprobabilistic tractographydiffusion tensor imaging |
| spellingShingle | Fei Wu Ping Dong Guowei Wu Jiahui Deng Zhaojun Ni Xuejiao Gao Peng Li Bing Li Junliang Yuan Hongqiang Sun Impulsivity trait mediates the relationship between white matter integrity of prefrontal–striatal circuits and the severity of dependence in alcoholism Frontiers in Psychiatry alcohol dependence impulsivity systematic striatal circuits probabilistic tractography diffusion tensor imaging |
| title | Impulsivity trait mediates the relationship between white matter integrity of prefrontal–striatal circuits and the severity of dependence in alcoholism |
| title_full | Impulsivity trait mediates the relationship between white matter integrity of prefrontal–striatal circuits and the severity of dependence in alcoholism |
| title_fullStr | Impulsivity trait mediates the relationship between white matter integrity of prefrontal–striatal circuits and the severity of dependence in alcoholism |
| title_full_unstemmed | Impulsivity trait mediates the relationship between white matter integrity of prefrontal–striatal circuits and the severity of dependence in alcoholism |
| title_short | Impulsivity trait mediates the relationship between white matter integrity of prefrontal–striatal circuits and the severity of dependence in alcoholism |
| title_sort | impulsivity trait mediates the relationship between white matter integrity of prefrontal striatal circuits and the severity of dependence in alcoholism |
| topic | alcohol dependence impulsivity systematic striatal circuits probabilistic tractography diffusion tensor imaging |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.985948/full |
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