Transposable Elements in the Genome of Human Parasite <i>Schistosoma mansoni</i>: A Review
Transposable elements (TEs) are DNA sequences able to transpose within the host genome and, consequently, influence the dynamics of evolution in the species. Among the possible effects, TEs insertions may alter the expression and coding patterns of genes, leading to genomic innovations. Gene-duplica...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-07-01
|
| Series: | Tropical Medicine and Infectious Disease |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2414-6366/6/3/126 |
| _version_ | 1797517070825422848 |
|---|---|
| author | Gisele Strieder Philippsen |
| author_facet | Gisele Strieder Philippsen |
| author_sort | Gisele Strieder Philippsen |
| collection | DOAJ |
| description | Transposable elements (TEs) are DNA sequences able to transpose within the host genome and, consequently, influence the dynamics of evolution in the species. Among the possible effects, TEs insertions may alter the expression and coding patterns of genes, leading to genomic innovations. Gene-duplication events, resulting from DNA segmental duplication induced by TEs transposition, constitute another important mechanism that contributes to the plasticity of genomes. This review aims to cover the current knowledge regarding TEs in the genome of the parasite <i>Schistosoma mansoni</i>, an agent of schistosomiasis—a neglected tropical disease affecting at least 250 million people worldwide. In this context, the literature concerning TEs description and TEs impact on the genomic architecture for <i>S. mansoni</i> was revisited, displaying evidence of TEs influence on schistosome speciation—mediated by bursts of transposition—and in gene-duplication events related to schistosome–host coevolution processes, as well several instances of TEs contribution into the coding sequences of genes. These findings indicate the relevant role of TEs in the evolution of the <i>S. mansoni</i> genome. |
| first_indexed | 2024-03-10T07:09:41Z |
| format | Article |
| id | doaj.art-746a414a2044439fbe1795026d9a225f |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-10T07:09:41Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-746a414a2044439fbe1795026d9a225f2023-11-22T15:32:05ZengMDPI AGTropical Medicine and Infectious Disease2414-63662021-07-016312610.3390/tropicalmed6030126Transposable Elements in the Genome of Human Parasite <i>Schistosoma mansoni</i>: A ReviewGisele Strieder Philippsen0Universidade Federal do Paraná, Jandaia do Sul, Dr. Maximiano Street, Parana n. 426, BrazilTransposable elements (TEs) are DNA sequences able to transpose within the host genome and, consequently, influence the dynamics of evolution in the species. Among the possible effects, TEs insertions may alter the expression and coding patterns of genes, leading to genomic innovations. Gene-duplication events, resulting from DNA segmental duplication induced by TEs transposition, constitute another important mechanism that contributes to the plasticity of genomes. This review aims to cover the current knowledge regarding TEs in the genome of the parasite <i>Schistosoma mansoni</i>, an agent of schistosomiasis—a neglected tropical disease affecting at least 250 million people worldwide. In this context, the literature concerning TEs description and TEs impact on the genomic architecture for <i>S. mansoni</i> was revisited, displaying evidence of TEs influence on schistosome speciation—mediated by bursts of transposition—and in gene-duplication events related to schistosome–host coevolution processes, as well several instances of TEs contribution into the coding sequences of genes. These findings indicate the relevant role of TEs in the evolution of the <i>S. mansoni</i> genome.https://www.mdpi.com/2414-6366/6/3/126transposable elements<i>S. mansoni</i>genome evolution |
| spellingShingle | Gisele Strieder Philippsen Transposable Elements in the Genome of Human Parasite <i>Schistosoma mansoni</i>: A Review Tropical Medicine and Infectious Disease transposable elements <i>S. mansoni</i> genome evolution |
| title | Transposable Elements in the Genome of Human Parasite <i>Schistosoma mansoni</i>: A Review |
| title_full | Transposable Elements in the Genome of Human Parasite <i>Schistosoma mansoni</i>: A Review |
| title_fullStr | Transposable Elements in the Genome of Human Parasite <i>Schistosoma mansoni</i>: A Review |
| title_full_unstemmed | Transposable Elements in the Genome of Human Parasite <i>Schistosoma mansoni</i>: A Review |
| title_short | Transposable Elements in the Genome of Human Parasite <i>Schistosoma mansoni</i>: A Review |
| title_sort | transposable elements in the genome of human parasite i schistosoma mansoni i a review |
| topic | transposable elements <i>S. mansoni</i> genome evolution |
| url | https://www.mdpi.com/2414-6366/6/3/126 |
| work_keys_str_mv | AT giselestriederphilippsen transposableelementsinthegenomeofhumanparasiteischistosomamansoniiareview |