Age-related prevalence and characteristics of Aggregatibacter actinomycetemcomitans in periodontitis patients living in Sweden
Background: The presence of Aggregatibacter actinomycetemcomitans in patients with periodontitis has been extensively studied for decades. Objective: To study the prevalence of A. actinomycetemcomitans in younger and older periodontitis patients and to genetically characterize isolates of this bacte...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-01-01
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| Series: | Journal of Oral Microbiology |
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| Online Access: | http://dx.doi.org/10.1080/20002297.2017.1334504 |
| _version_ | 1818479149832994816 |
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| author | Rolf Claesson Carola Höglund-Åberg Dorte Haubek Anders Johansson |
| author_facet | Rolf Claesson Carola Höglund-Åberg Dorte Haubek Anders Johansson |
| author_sort | Rolf Claesson |
| collection | DOAJ |
| description | Background: The presence of Aggregatibacter actinomycetemcomitans in patients with periodontitis has been extensively studied for decades. Objective: To study the prevalence of A. actinomycetemcomitans in younger and older periodontitis patients and to genetically characterize isolates of this bacterium. Design: Data from microbiological analyses of 3459 subgingival plaque samples collected from 1445 patients, 337 ‘younger’ patients (≤35 yrs) and 1108 ‘older’ patients (>35 yrs) during 15 years (2000–2014), has been summerized. Isolates of A. actinomycetemcomitans were serotyped, leukotoxin promoter typed (JP2 and non JP2) and arbitrarily primed PCR (AP-PCR) genotyped. The origin of the JP2 genotype detected in the study population was determined. Results: The prevalence of A. actinomycetemcomitans was higher among younger than older patients and samples from the younger patients contained higher proportions of the bacterium. Serotype b was more prevalent among younger patients and the majorty of these isolates was from the same AP-PCR genotype. The JP2 genotype was detected in 1.2% of the patients, and the majority of these carriers were of non-African origin. Conslusions: For presence and charcteristics of A. actinomycetemcomitans in clinical samples the age of the carriers were a discriminating factor. Additional, apparently non-African carriers of the JP2 genotype of A. actinomycetemcomitans were identified. |
| first_indexed | 2024-12-10T09:56:59Z |
| format | Article |
| id | doaj.art-746b587542ae4c928faa4f9ae5b2b975 |
| institution | Directory Open Access Journal |
| issn | 2000-2297 |
| language | English |
| last_indexed | 2024-12-10T09:56:59Z |
| publishDate | 2017-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Oral Microbiology |
| spelling | doaj.art-746b587542ae4c928faa4f9ae5b2b9752022-12-22T01:53:28ZengTaylor & Francis GroupJournal of Oral Microbiology2000-22972017-01-019110.1080/20002297.2017.13345041334504Age-related prevalence and characteristics of Aggregatibacter actinomycetemcomitans in periodontitis patients living in SwedenRolf Claesson0Carola Höglund-Åberg1Dorte Haubek2Anders Johansson3Umeå UniversityUmeå UniversityHealth, Aarhus UniversityUmeå UniversityBackground: The presence of Aggregatibacter actinomycetemcomitans in patients with periodontitis has been extensively studied for decades. Objective: To study the prevalence of A. actinomycetemcomitans in younger and older periodontitis patients and to genetically characterize isolates of this bacterium. Design: Data from microbiological analyses of 3459 subgingival plaque samples collected from 1445 patients, 337 ‘younger’ patients (≤35 yrs) and 1108 ‘older’ patients (>35 yrs) during 15 years (2000–2014), has been summerized. Isolates of A. actinomycetemcomitans were serotyped, leukotoxin promoter typed (JP2 and non JP2) and arbitrarily primed PCR (AP-PCR) genotyped. The origin of the JP2 genotype detected in the study population was determined. Results: The prevalence of A. actinomycetemcomitans was higher among younger than older patients and samples from the younger patients contained higher proportions of the bacterium. Serotype b was more prevalent among younger patients and the majorty of these isolates was from the same AP-PCR genotype. The JP2 genotype was detected in 1.2% of the patients, and the majority of these carriers were of non-African origin. Conslusions: For presence and charcteristics of A. actinomycetemcomitans in clinical samples the age of the carriers were a discriminating factor. Additional, apparently non-African carriers of the JP2 genotype of A. actinomycetemcomitans were identified.http://dx.doi.org/10.1080/20002297.2017.1334504Aggregatibacter actinomycetemcomitansleukotoxinJP2serotypesAP-PCR genotypesmicrobiological diagnostics |
| spellingShingle | Rolf Claesson Carola Höglund-Åberg Dorte Haubek Anders Johansson Age-related prevalence and characteristics of Aggregatibacter actinomycetemcomitans in periodontitis patients living in Sweden Journal of Oral Microbiology Aggregatibacter actinomycetemcomitans leukotoxin JP2 serotypes AP-PCR genotypes microbiological diagnostics |
| title | Age-related prevalence and characteristics of Aggregatibacter actinomycetemcomitans in periodontitis patients living in Sweden |
| title_full | Age-related prevalence and characteristics of Aggregatibacter actinomycetemcomitans in periodontitis patients living in Sweden |
| title_fullStr | Age-related prevalence and characteristics of Aggregatibacter actinomycetemcomitans in periodontitis patients living in Sweden |
| title_full_unstemmed | Age-related prevalence and characteristics of Aggregatibacter actinomycetemcomitans in periodontitis patients living in Sweden |
| title_short | Age-related prevalence and characteristics of Aggregatibacter actinomycetemcomitans in periodontitis patients living in Sweden |
| title_sort | age related prevalence and characteristics of aggregatibacter actinomycetemcomitans in periodontitis patients living in sweden |
| topic | Aggregatibacter actinomycetemcomitans leukotoxin JP2 serotypes AP-PCR genotypes microbiological diagnostics |
| url | http://dx.doi.org/10.1080/20002297.2017.1334504 |
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