Efficacy of compound middle-layer acid combined with 30% supramolecular salicylic acid for melasma

Objective To evaluate the therapeutic efficacy of a combination of compound middle-layer acid and 30% supramolecular salicylic acid for melasma. Methods Five female patients with melasma who were admitted to our hospital from May 2022 to December 2022 were enrolled in this study. A self-parallel con...

Full description

Bibliographic Details
Main Authors: Yu SUN, Congxiu YE, Jiaojiao FU, Xinling CHEN, Feng ZHOU, Yuhan JIANG, Wei LAI, Yue ZHENG
Format: Article
Language:zho
Published: editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology 2023-12-01
Series:Pifu-xingbing zhenliaoxue zazhi
Subjects:
Online Access:http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2023.06.004
_version_ 1797249346764275712
author Yu SUN
Congxiu YE
Jiaojiao FU
Xinling CHEN
Feng ZHOU
Yuhan JIANG
Wei LAI
Yue ZHENG
author_facet Yu SUN
Congxiu YE
Jiaojiao FU
Xinling CHEN
Feng ZHOU
Yuhan JIANG
Wei LAI
Yue ZHENG
author_sort Yu SUN
collection DOAJ
description Objective To evaluate the therapeutic efficacy of a combination of compound middle-layer acid and 30% supramolecular salicylic acid for melasma. Methods Five female patients with melasma who were admitted to our hospital from May 2022 to December 2022 were enrolled in this study. A self-parallel controlled study was carried out. The patients' treated side was treated with compound middle-layer acid while the control side was treated with 30% supramolecular salicylic acid at weeks 0 and 4. On week 8, the treated side and control side were treated with 30% supramolecular salicylic acid and compound middle-layer acid, respectively. We compared the area score of facial lesions, skin color, sebum, water content and the severity of melasma-related psychological stress between the two sides. Results The combination therapy significantly decreased the area scores on the forehead, cheek and chin (P<0.05). In contrast, only the area scores on the forehead were decreased on the control side. Although the color scores were decreased on the forehead, cheek and chin of both sides, significant decrease was observed on the treated side (P<0.05 vs. the control side). Similarly, both treatments increased sebum content, with a prominent increase on the treated side (P<0.05 vs. the control side). The changes in water content did not differ significantly between these two treatments (P>0.10). Moreover, the combination therapy decreased both SAS (from 21.62±5.99 to 20.86±6.44, P<0.05) and SDS scores (from 25.05±4.21 to 23.33±5.12, P<0.05). Conclusions The combination therapy of compound middle-layer acid and 30% supramolecular salicylic acid can significantly improve the facial skin lesions and psychological state of patients with melasma. Better results can be achieved by using compound middle-layer acid first, followed by 30% supramolecular salicylic acid.
first_indexed 2024-04-24T20:29:02Z
format Article
id doaj.art-746c8e3228e7417b87f595ee054b7b34
institution Directory Open Access Journal
issn 1674-8468
language zho
last_indexed 2024-04-24T20:29:02Z
publishDate 2023-12-01
publisher editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology
record_format Article
series Pifu-xingbing zhenliaoxue zazhi
spelling doaj.art-746c8e3228e7417b87f595ee054b7b342024-03-22T02:46:48Zzhoeditoiral office of Journal of Diagnosis and Therapy on Dermato-venereologyPifu-xingbing zhenliaoxue zazhi1674-84682023-12-0130650250810.3969/j.issn.1674-8468.2023.06.004Efficacy of compound middle-layer acid combined with 30% supramolecular salicylic acid for melasmaYu SUN0Congxiu YE1Jiaojiao FU2Xinling CHEN3Feng ZHOU4Yuhan JIANG5Wei LAI6Yue ZHENG7Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaThird Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaGuangzhou Laipu Testing Technology Co. LTD., Guangzhou 510000, ChinaThird Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaThird Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaThird Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaThird Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaThird Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaObjective To evaluate the therapeutic efficacy of a combination of compound middle-layer acid and 30% supramolecular salicylic acid for melasma. Methods Five female patients with melasma who were admitted to our hospital from May 2022 to December 2022 were enrolled in this study. A self-parallel controlled study was carried out. The patients' treated side was treated with compound middle-layer acid while the control side was treated with 30% supramolecular salicylic acid at weeks 0 and 4. On week 8, the treated side and control side were treated with 30% supramolecular salicylic acid and compound middle-layer acid, respectively. We compared the area score of facial lesions, skin color, sebum, water content and the severity of melasma-related psychological stress between the two sides. Results The combination therapy significantly decreased the area scores on the forehead, cheek and chin (P<0.05). In contrast, only the area scores on the forehead were decreased on the control side. Although the color scores were decreased on the forehead, cheek and chin of both sides, significant decrease was observed on the treated side (P<0.05 vs. the control side). Similarly, both treatments increased sebum content, with a prominent increase on the treated side (P<0.05 vs. the control side). The changes in water content did not differ significantly between these two treatments (P>0.10). Moreover, the combination therapy decreased both SAS (from 21.62±5.99 to 20.86±6.44, P<0.05) and SDS scores (from 25.05±4.21 to 23.33±5.12, P<0.05). Conclusions The combination therapy of compound middle-layer acid and 30% supramolecular salicylic acid can significantly improve the facial skin lesions and psychological state of patients with melasma. Better results can be achieved by using compound middle-layer acid first, followed by 30% supramolecular salicylic acid.http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2023.06.004melasmacompound middle-layer acidsalicylic acid
spellingShingle Yu SUN
Congxiu YE
Jiaojiao FU
Xinling CHEN
Feng ZHOU
Yuhan JIANG
Wei LAI
Yue ZHENG
Efficacy of compound middle-layer acid combined with 30% supramolecular salicylic acid for melasma
Pifu-xingbing zhenliaoxue zazhi
melasma
compound middle-layer acid
salicylic acid
title Efficacy of compound middle-layer acid combined with 30% supramolecular salicylic acid for melasma
title_full Efficacy of compound middle-layer acid combined with 30% supramolecular salicylic acid for melasma
title_fullStr Efficacy of compound middle-layer acid combined with 30% supramolecular salicylic acid for melasma
title_full_unstemmed Efficacy of compound middle-layer acid combined with 30% supramolecular salicylic acid for melasma
title_short Efficacy of compound middle-layer acid combined with 30% supramolecular salicylic acid for melasma
title_sort efficacy of compound middle layer acid combined with 30 supramolecular salicylic acid for melasma
topic melasma
compound middle-layer acid
salicylic acid
url http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2023.06.004
work_keys_str_mv AT yusun efficacyofcompoundmiddlelayeracidcombinedwith30supramolecularsalicylicacidformelasma
AT congxiuye efficacyofcompoundmiddlelayeracidcombinedwith30supramolecularsalicylicacidformelasma
AT jiaojiaofu efficacyofcompoundmiddlelayeracidcombinedwith30supramolecularsalicylicacidformelasma
AT xinlingchen efficacyofcompoundmiddlelayeracidcombinedwith30supramolecularsalicylicacidformelasma
AT fengzhou efficacyofcompoundmiddlelayeracidcombinedwith30supramolecularsalicylicacidformelasma
AT yuhanjiang efficacyofcompoundmiddlelayeracidcombinedwith30supramolecularsalicylicacidformelasma
AT weilai efficacyofcompoundmiddlelayeracidcombinedwith30supramolecularsalicylicacidformelasma
AT yuezheng efficacyofcompoundmiddlelayeracidcombinedwith30supramolecularsalicylicacidformelasma