Relevance of Smoking Habit in Severe Asthma Patients: Evidence from the Severe Asthma Network in Italy (SANI) Registry
Smoking habit is still fairly common among asthmatics. So far, the impact of smoke on severe asthma burden has not been specifically investigated. We aimed to estimate the frequency of smoking habit among severe asthma patients, their clinical features, and the impact of smoke on asthma outcomes. Th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/24/7465 |
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| author | Marco Caminati Gabriella Guarnieri Pierluigi Paggiaro Andrea Vianello Ernesto Crisafulli Rachele Vaia Gianenrico Senna |
| author_facet | Marco Caminati Gabriella Guarnieri Pierluigi Paggiaro Andrea Vianello Ernesto Crisafulli Rachele Vaia Gianenrico Senna |
| author_sort | Marco Caminati |
| collection | DOAJ |
| description | Smoking habit is still fairly common among asthmatics. So far, the impact of smoke on severe asthma burden has not been specifically investigated. We aimed to estimate the frequency of smoking habit among severe asthma patients, their clinical features, and the impact of smoke on asthma outcomes. The Severe Asthma Network in Italy (SANI) registry was analyzed. Demographic, clinical, and functional features of smokers, never and former smokers were compared. Data from 1194 patients were explored. Smokers were younger, with a lower asthma onset age. Atopy, BMI and respiratory/systemic comorbidities were equally distributed. In former smokers pre- and post-FEV1/FVC was significantly lower; no other significant differences were detected. Similar findings were confirmed when stratifying the former smokers by pack-years and length of smoking cessation. Among former smokers, lymphocytes and neutrophils were higher in the <15 years of smoking cessation group. Blood eosinophils were comparable in never and former smokers. When clustering the population by blood eosinophils, no significant differences in pulmonary function and exacerbations were observed. Our data suggest that a personal smoking history has a relatively low impact on disease burden. It remarks the importance of smoking cessation as a main intervention, particularly in severe asthma. |
| first_indexed | 2024-03-09T16:15:51Z |
| format | Article |
| id | doaj.art-746f852b78124c4aa2dd6cfd3b4ef982 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T16:15:51Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-746f852b78124c4aa2dd6cfd3b4ef9822023-11-24T15:46:05ZengMDPI AGJournal of Clinical Medicine2077-03832022-12-011124746510.3390/jcm11247465Relevance of Smoking Habit in Severe Asthma Patients: Evidence from the Severe Asthma Network in Italy (SANI) RegistryMarco Caminati0Gabriella Guarnieri1Pierluigi Paggiaro2Andrea Vianello3Ernesto Crisafulli4Rachele Vaia5Gianenrico Senna6Department of Medicine, University of Verona, 37134 Verona, ItalyDepartment of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, 35122 Padua, ItalyDepartment of Surgery, Medicine, Molecular Biology and Critical Care, University of Pisa, 56126 Pisa, ItalyDepartment of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, 35122 Padua, ItalyRespiratory Medicine Unit, Department of Medicine, University of Verona and Verona University Hospital, 37134 Verona, ItalyAllergy Unit and Asthma Center, Verona University Hospital, 37134 Verona, ItalyDepartment of Medicine, University of Verona, 37134 Verona, ItalySmoking habit is still fairly common among asthmatics. So far, the impact of smoke on severe asthma burden has not been specifically investigated. We aimed to estimate the frequency of smoking habit among severe asthma patients, their clinical features, and the impact of smoke on asthma outcomes. The Severe Asthma Network in Italy (SANI) registry was analyzed. Demographic, clinical, and functional features of smokers, never and former smokers were compared. Data from 1194 patients were explored. Smokers were younger, with a lower asthma onset age. Atopy, BMI and respiratory/systemic comorbidities were equally distributed. In former smokers pre- and post-FEV1/FVC was significantly lower; no other significant differences were detected. Similar findings were confirmed when stratifying the former smokers by pack-years and length of smoking cessation. Among former smokers, lymphocytes and neutrophils were higher in the <15 years of smoking cessation group. Blood eosinophils were comparable in never and former smokers. When clustering the population by blood eosinophils, no significant differences in pulmonary function and exacerbations were observed. Our data suggest that a personal smoking history has a relatively low impact on disease burden. It remarks the importance of smoking cessation as a main intervention, particularly in severe asthma.https://www.mdpi.com/2077-0383/11/24/7465severe asthmacigarette smokingSevere Asthma Network in Italyeosinophilslung function |
| spellingShingle | Marco Caminati Gabriella Guarnieri Pierluigi Paggiaro Andrea Vianello Ernesto Crisafulli Rachele Vaia Gianenrico Senna Relevance of Smoking Habit in Severe Asthma Patients: Evidence from the Severe Asthma Network in Italy (SANI) Registry Journal of Clinical Medicine severe asthma cigarette smoking Severe Asthma Network in Italy eosinophils lung function |
| title | Relevance of Smoking Habit in Severe Asthma Patients: Evidence from the Severe Asthma Network in Italy (SANI) Registry |
| title_full | Relevance of Smoking Habit in Severe Asthma Patients: Evidence from the Severe Asthma Network in Italy (SANI) Registry |
| title_fullStr | Relevance of Smoking Habit in Severe Asthma Patients: Evidence from the Severe Asthma Network in Italy (SANI) Registry |
| title_full_unstemmed | Relevance of Smoking Habit in Severe Asthma Patients: Evidence from the Severe Asthma Network in Italy (SANI) Registry |
| title_short | Relevance of Smoking Habit in Severe Asthma Patients: Evidence from the Severe Asthma Network in Italy (SANI) Registry |
| title_sort | relevance of smoking habit in severe asthma patients evidence from the severe asthma network in italy sani registry |
| topic | severe asthma cigarette smoking Severe Asthma Network in Italy eosinophils lung function |
| url | https://www.mdpi.com/2077-0383/11/24/7465 |
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