Identification of CD318, TSPAN8 and CD66c as target candidates for CAR T cell based immunotherapy of pancreatic adenocarcinoma
There is an unmet clinical need to identify therapeutic options for the treatment of pancreatic cancer (PDAC). Here the authors present a systematic screening approach for the identification of potential PDAC cell surface target candidates for CAR-T cell based immunotherapy, followed by their functi...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-03-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21774-4 |
| _version_ | 1818430939624112128 |
|---|---|
| author | Daniel Schäfer Stefan Tomiuk Laura N. Küster Wa’el Al Rawashdeh Janina Henze German Tischler-Höhle David J. Agorku Janina Brauner Cathrin Linnartz Dominik Lock Andrew Kaiser Christoph Herbel Dominik Eckardt Melina Lamorte Dorothee Lenhard Julia Schüler Philipp Ströbel Jeannine Missbach-Guentner Diana Pinkert-Leetsch Frauke Alves Andreas Bosio Olaf Hardt |
| author_facet | Daniel Schäfer Stefan Tomiuk Laura N. Küster Wa’el Al Rawashdeh Janina Henze German Tischler-Höhle David J. Agorku Janina Brauner Cathrin Linnartz Dominik Lock Andrew Kaiser Christoph Herbel Dominik Eckardt Melina Lamorte Dorothee Lenhard Julia Schüler Philipp Ströbel Jeannine Missbach-Guentner Diana Pinkert-Leetsch Frauke Alves Andreas Bosio Olaf Hardt |
| author_sort | Daniel Schäfer |
| collection | DOAJ |
| description | There is an unmet clinical need to identify therapeutic options for the treatment of pancreatic cancer (PDAC). Here the authors present a systematic screening approach for the identification of potential PDAC cell surface target candidates for CAR-T cell based immunotherapy, followed by their functional validation in preclinical models. |
| first_indexed | 2024-12-14T15:41:23Z |
| format | Article |
| id | doaj.art-74706aa5d24748cbad4a75025edf6014 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T15:41:23Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-74706aa5d24748cbad4a75025edf60142022-12-21T22:55:36ZengNature PortfolioNature Communications2041-17232021-03-0112111810.1038/s41467-021-21774-4Identification of CD318, TSPAN8 and CD66c as target candidates for CAR T cell based immunotherapy of pancreatic adenocarcinomaDaniel Schäfer0Stefan Tomiuk1Laura N. Küster2Wa’el Al Rawashdeh3Janina Henze4German Tischler-Höhle5David J. Agorku6Janina Brauner7Cathrin Linnartz8Dominik Lock9Andrew Kaiser10Christoph Herbel11Dominik Eckardt12Melina Lamorte13Dorothee Lenhard14Julia Schüler15Philipp Ströbel16Jeannine Missbach-Guentner17Diana Pinkert-Leetsch18Frauke Alves19Andreas Bosio20Olaf Hardt21Miltenyi Biotec GmbH, R&DMiltenyi Biotec GmbH, R&DMiltenyi Biotec GmbH, R&DMiltenyi Biotec GmbH, R&DMiltenyi Biotec GmbH, R&DMiltenyi Biotec GmbH, R&DMiltenyi Biotec GmbH, R&DMiltenyi Biotec GmbH, R&DMiltenyi Biotec GmbH, R&DMiltenyi Biotec GmbH, R&DMiltenyi Biotec GmbH, R&DMiltenyi Biotec GmbH, R&DMiltenyi Biotec GmbH, R&DCharles River Discovery Research Services GmbHCharles River Discovery Research Services GmbHCharles River Discovery Research Services GmbHUniversity Medical Center Göttingen, Institute for PathologyUniversity Medical Center Göttingen, Institute for Diagnostic and Interventional RadiologyUniversity Medical Center Göttingen, Institute for Diagnostic and Interventional RadiologyUniversity Medical Center Göttingen, Clinic for Hematology and Medical OncologyMiltenyi Biotec GmbH, R&DMiltenyi Biotec GmbH, R&DThere is an unmet clinical need to identify therapeutic options for the treatment of pancreatic cancer (PDAC). Here the authors present a systematic screening approach for the identification of potential PDAC cell surface target candidates for CAR-T cell based immunotherapy, followed by their functional validation in preclinical models.https://doi.org/10.1038/s41467-021-21774-4 |
| spellingShingle | Daniel Schäfer Stefan Tomiuk Laura N. Küster Wa’el Al Rawashdeh Janina Henze German Tischler-Höhle David J. Agorku Janina Brauner Cathrin Linnartz Dominik Lock Andrew Kaiser Christoph Herbel Dominik Eckardt Melina Lamorte Dorothee Lenhard Julia Schüler Philipp Ströbel Jeannine Missbach-Guentner Diana Pinkert-Leetsch Frauke Alves Andreas Bosio Olaf Hardt Identification of CD318, TSPAN8 and CD66c as target candidates for CAR T cell based immunotherapy of pancreatic adenocarcinoma Nature Communications |
| title | Identification of CD318, TSPAN8 and CD66c as target candidates for CAR T cell based immunotherapy of pancreatic adenocarcinoma |
| title_full | Identification of CD318, TSPAN8 and CD66c as target candidates for CAR T cell based immunotherapy of pancreatic adenocarcinoma |
| title_fullStr | Identification of CD318, TSPAN8 and CD66c as target candidates for CAR T cell based immunotherapy of pancreatic adenocarcinoma |
| title_full_unstemmed | Identification of CD318, TSPAN8 and CD66c as target candidates for CAR T cell based immunotherapy of pancreatic adenocarcinoma |
| title_short | Identification of CD318, TSPAN8 and CD66c as target candidates for CAR T cell based immunotherapy of pancreatic adenocarcinoma |
| title_sort | identification of cd318 tspan8 and cd66c as target candidates for car t cell based immunotherapy of pancreatic adenocarcinoma |
| url | https://doi.org/10.1038/s41467-021-21774-4 |
| work_keys_str_mv | AT danielschafer identificationofcd318tspan8andcd66castargetcandidatesforcartcellbasedimmunotherapyofpancreaticadenocarcinoma AT stefantomiuk identificationofcd318tspan8andcd66castargetcandidatesforcartcellbasedimmunotherapyofpancreaticadenocarcinoma AT laurankuster identificationofcd318tspan8andcd66castargetcandidatesforcartcellbasedimmunotherapyofpancreaticadenocarcinoma AT waelalrawashdeh identificationofcd318tspan8andcd66castargetcandidatesforcartcellbasedimmunotherapyofpancreaticadenocarcinoma AT janinahenze identificationofcd318tspan8andcd66castargetcandidatesforcartcellbasedimmunotherapyofpancreaticadenocarcinoma AT germantischlerhohle identificationofcd318tspan8andcd66castargetcandidatesforcartcellbasedimmunotherapyofpancreaticadenocarcinoma AT davidjagorku identificationofcd318tspan8andcd66castargetcandidatesforcartcellbasedimmunotherapyofpancreaticadenocarcinoma AT janinabrauner identificationofcd318tspan8andcd66castargetcandidatesforcartcellbasedimmunotherapyofpancreaticadenocarcinoma AT cathrinlinnartz identificationofcd318tspan8andcd66castargetcandidatesforcartcellbasedimmunotherapyofpancreaticadenocarcinoma AT dominiklock identificationofcd318tspan8andcd66castargetcandidatesforcartcellbasedimmunotherapyofpancreaticadenocarcinoma AT andrewkaiser identificationofcd318tspan8andcd66castargetcandidatesforcartcellbasedimmunotherapyofpancreaticadenocarcinoma AT christophherbel identificationofcd318tspan8andcd66castargetcandidatesforcartcellbasedimmunotherapyofpancreaticadenocarcinoma AT dominikeckardt identificationofcd318tspan8andcd66castargetcandidatesforcartcellbasedimmunotherapyofpancreaticadenocarcinoma AT melinalamorte identificationofcd318tspan8andcd66castargetcandidatesforcartcellbasedimmunotherapyofpancreaticadenocarcinoma AT dorotheelenhard identificationofcd318tspan8andcd66castargetcandidatesforcartcellbasedimmunotherapyofpancreaticadenocarcinoma AT juliaschuler identificationofcd318tspan8andcd66castargetcandidatesforcartcellbasedimmunotherapyofpancreaticadenocarcinoma AT philippstrobel identificationofcd318tspan8andcd66castargetcandidatesforcartcellbasedimmunotherapyofpancreaticadenocarcinoma AT jeanninemissbachguentner identificationofcd318tspan8andcd66castargetcandidatesforcartcellbasedimmunotherapyofpancreaticadenocarcinoma AT dianapinkertleetsch identificationofcd318tspan8andcd66castargetcandidatesforcartcellbasedimmunotherapyofpancreaticadenocarcinoma AT fraukealves identificationofcd318tspan8andcd66castargetcandidatesforcartcellbasedimmunotherapyofpancreaticadenocarcinoma AT andreasbosio identificationofcd318tspan8andcd66castargetcandidatesforcartcellbasedimmunotherapyofpancreaticadenocarcinoma AT olafhardt identificationofcd318tspan8andcd66castargetcandidatesforcartcellbasedimmunotherapyofpancreaticadenocarcinoma |