Metastatic Clear Cell Renal Cell Carcinoma to Pancreas and Distant Organs 24 Years After Radical Nephrectomy: A Case Report and Literature Review
BackgroundClear cell renal cell carcinoma (CCRCC) is a common urological neoplasm, and even though surgical resection is effective for localized CCRCC, the prognosis of metastatic CCRCC is poor. Currently, there is a paucity of recognized effective therapeutic protocols for metastatic CCRCC.Case pre...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-07-01
|
| Series: | Frontiers in Surgery |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2022.894272/full |
| _version_ | 1818536577469513728 |
|---|---|
| author | Huawei Cao Huawei Cao Zejia Sun Zejia Sun Jiyue Wu Jiyue Wu Changzhen Hao Changzhen Hao Wei Wang Wei Wang |
| author_facet | Huawei Cao Huawei Cao Zejia Sun Zejia Sun Jiyue Wu Jiyue Wu Changzhen Hao Changzhen Hao Wei Wang Wei Wang |
| author_sort | Huawei Cao |
| collection | DOAJ |
| description | BackgroundClear cell renal cell carcinoma (CCRCC) is a common urological neoplasm, and even though surgical resection is effective for localized CCRCC, the prognosis of metastatic CCRCC is poor. Currently, there is a paucity of recognized effective therapeutic protocols for metastatic CCRCC.Case presentationA 76-year-old Asian man underwent radical left nephrectomy for CCRCC 26 years ago; this patient visited our hospital with abdominal pain due to multiple abdominal metastases 24 years after the nephrectomy. After metastasectomy, he underwent targeted therapy combined with a programmed death receptor-1 (PD-1) inhibitor, and the current imaging results indicate remarkable tumor remission.ConclusionsMetachronous pancreatic metastasis from CCRCC after nephrectomy is rare, but clinicians and patients should not ignore this possibility. The combination of targeted therapy and immunotherapy can result in satisfactory outcomes in cases where metastatic CCRCC continues to progress despite metastasectomy and targeted therapy. The combination of local and systemic therapy can be an effective therapeutic protocol for metastatic CCRCC, but there is no consensus on suitable therapeutics. |
| first_indexed | 2024-12-11T18:39:45Z |
| format | Article |
| id | doaj.art-74740597ca7c4029a7a8905d15e64486 |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-12-11T18:39:45Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-74740597ca7c4029a7a8905d15e644862022-12-22T00:54:39ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2022-07-01910.3389/fsurg.2022.894272894272Metastatic Clear Cell Renal Cell Carcinoma to Pancreas and Distant Organs 24 Years After Radical Nephrectomy: A Case Report and Literature ReviewHuawei Cao0Huawei Cao1Zejia Sun2Zejia Sun3Jiyue Wu4Jiyue Wu5Changzhen Hao6Changzhen Hao7Wei Wang8Wei Wang9Department of Urology, Beijing Chao-yang Hospital, Capital Medical University, Beijing, ChinaInstitute of Urology, Capital Medical University, Beijing, ChinaDepartment of Urology, Beijing Chao-yang Hospital, Capital Medical University, Beijing, ChinaInstitute of Urology, Capital Medical University, Beijing, ChinaDepartment of Urology, Beijing Chao-yang Hospital, Capital Medical University, Beijing, ChinaInstitute of Urology, Capital Medical University, Beijing, ChinaDepartment of Urology, Beijing Chao-yang Hospital, Capital Medical University, Beijing, ChinaInstitute of Urology, Capital Medical University, Beijing, ChinaDepartment of Urology, Beijing Chao-yang Hospital, Capital Medical University, Beijing, ChinaInstitute of Urology, Capital Medical University, Beijing, ChinaBackgroundClear cell renal cell carcinoma (CCRCC) is a common urological neoplasm, and even though surgical resection is effective for localized CCRCC, the prognosis of metastatic CCRCC is poor. Currently, there is a paucity of recognized effective therapeutic protocols for metastatic CCRCC.Case presentationA 76-year-old Asian man underwent radical left nephrectomy for CCRCC 26 years ago; this patient visited our hospital with abdominal pain due to multiple abdominal metastases 24 years after the nephrectomy. After metastasectomy, he underwent targeted therapy combined with a programmed death receptor-1 (PD-1) inhibitor, and the current imaging results indicate remarkable tumor remission.ConclusionsMetachronous pancreatic metastasis from CCRCC after nephrectomy is rare, but clinicians and patients should not ignore this possibility. The combination of targeted therapy and immunotherapy can result in satisfactory outcomes in cases where metastatic CCRCC continues to progress despite metastasectomy and targeted therapy. The combination of local and systemic therapy can be an effective therapeutic protocol for metastatic CCRCC, but there is no consensus on suitable therapeutics.https://www.frontiersin.org/articles/10.3389/fsurg.2022.894272/fullClear cell renal cell carcinomapancreatic metastasismetastasectomysystemic therapycombinatorial treatment |
| spellingShingle | Huawei Cao Huawei Cao Zejia Sun Zejia Sun Jiyue Wu Jiyue Wu Changzhen Hao Changzhen Hao Wei Wang Wei Wang Metastatic Clear Cell Renal Cell Carcinoma to Pancreas and Distant Organs 24 Years After Radical Nephrectomy: A Case Report and Literature Review Frontiers in Surgery Clear cell renal cell carcinoma pancreatic metastasis metastasectomy systemic therapy combinatorial treatment |
| title | Metastatic Clear Cell Renal Cell Carcinoma to Pancreas and Distant Organs 24 Years After Radical Nephrectomy: A Case Report and Literature Review |
| title_full | Metastatic Clear Cell Renal Cell Carcinoma to Pancreas and Distant Organs 24 Years After Radical Nephrectomy: A Case Report and Literature Review |
| title_fullStr | Metastatic Clear Cell Renal Cell Carcinoma to Pancreas and Distant Organs 24 Years After Radical Nephrectomy: A Case Report and Literature Review |
| title_full_unstemmed | Metastatic Clear Cell Renal Cell Carcinoma to Pancreas and Distant Organs 24 Years After Radical Nephrectomy: A Case Report and Literature Review |
| title_short | Metastatic Clear Cell Renal Cell Carcinoma to Pancreas and Distant Organs 24 Years After Radical Nephrectomy: A Case Report and Literature Review |
| title_sort | metastatic clear cell renal cell carcinoma to pancreas and distant organs 24 years after radical nephrectomy a case report and literature review |
| topic | Clear cell renal cell carcinoma pancreatic metastasis metastasectomy systemic therapy combinatorial treatment |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2022.894272/full |
| work_keys_str_mv | AT huaweicao metastaticclearcellrenalcellcarcinomatopancreasanddistantorgans24yearsafterradicalnephrectomyacasereportandliteraturereview AT huaweicao metastaticclearcellrenalcellcarcinomatopancreasanddistantorgans24yearsafterradicalnephrectomyacasereportandliteraturereview AT zejiasun metastaticclearcellrenalcellcarcinomatopancreasanddistantorgans24yearsafterradicalnephrectomyacasereportandliteraturereview AT zejiasun metastaticclearcellrenalcellcarcinomatopancreasanddistantorgans24yearsafterradicalnephrectomyacasereportandliteraturereview AT jiyuewu metastaticclearcellrenalcellcarcinomatopancreasanddistantorgans24yearsafterradicalnephrectomyacasereportandliteraturereview AT jiyuewu metastaticclearcellrenalcellcarcinomatopancreasanddistantorgans24yearsafterradicalnephrectomyacasereportandliteraturereview AT changzhenhao metastaticclearcellrenalcellcarcinomatopancreasanddistantorgans24yearsafterradicalnephrectomyacasereportandliteraturereview AT changzhenhao metastaticclearcellrenalcellcarcinomatopancreasanddistantorgans24yearsafterradicalnephrectomyacasereportandliteraturereview AT weiwang metastaticclearcellrenalcellcarcinomatopancreasanddistantorgans24yearsafterradicalnephrectomyacasereportandliteraturereview AT weiwang metastaticclearcellrenalcellcarcinomatopancreasanddistantorgans24yearsafterradicalnephrectomyacasereportandliteraturereview |