The Potential Prognostic Value of Dual-Imaging PET Parameters Based on 18F-FDG and 18F-OC for Neuroendocrine Neoplasms
Background. To identify parameters based on dual-imaging 18F-AlF-NOTA-octreotide (18F-OC) and 18-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) for predicting the prognosis of neuroendocrine neoplasms (NENs). Materials and Methods. Sixty-six patients (age: mean±standard deviation (S...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2022-01-01
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| Series: | Molecular Imaging |
| Online Access: | http://dx.doi.org/10.1155/2022/6511179 |
| _version_ | 1797283169821523968 |
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| author | Jiale Hou Tingting Long Yi Yang Dengming Chen Shuo Hu |
| author_facet | Jiale Hou Tingting Long Yi Yang Dengming Chen Shuo Hu |
| author_sort | Jiale Hou |
| collection | DOAJ |
| description | Background. To identify parameters based on dual-imaging 18F-AlF-NOTA-octreotide (18F-OC) and 18-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) for predicting the prognosis of neuroendocrine neoplasms (NENs). Materials and Methods. Sixty-six patients (age: mean±standard deviation (SD): 51.8±11.8 years) who underwent both 18F-OC and 18F-FDG PET/CT imaging were enrolled in our retrospective study. The following PET parameters were measured: the maximum standardized uptake value (SUVmax) and the volumetric parameters—18F-OC SSR-derived tumor volume (TV) and somatostatin receptor expression (SRE, TV multiplied by the mean standardized uptake value (SUVmean)) and the 18F-FDG-derived multiple tumor volume (MTV) and tumor lesion glycolysis (TLG). The NETPET grade based on dual-imaging PET images was assessed. Progression-free survival (PFS) was set as an endpoint. Univariate and multivariate survival analyses were performed for PET parameters and clinical tumor data. Results. In the univariate survival analyses of clinical information, PFS was significantly associated with age (>45.5 vs ≤45.5, years, P<0.034) and the presence of bone metastases (P=0.04). Higher values for the 18F-FDG and 18F-OC volumetric parameters and the NETPET grade were adverse factors for PFS according to the dual-imaging PET parameters. In the multivariate survival analysis, the NETPET grade and SRE were predictors of PFS in NEN patients. Conclusion. The NETPET grade is a potential noninvasive prognostic biomarker for NENs. |
| first_indexed | 2024-03-07T17:26:17Z |
| format | Article |
| id | doaj.art-7474302a9aa242229d8facd4e125c7cc |
| institution | Directory Open Access Journal |
| issn | 1536-0121 |
| language | English |
| last_indexed | 2024-03-07T17:26:17Z |
| publishDate | 2022-01-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj.art-7474302a9aa242229d8facd4e125c7cc2024-03-02T18:58:46ZengSAGE PublicationsMolecular Imaging1536-01212022-01-01202210.1155/2022/6511179The Potential Prognostic Value of Dual-Imaging PET Parameters Based on 18F-FDG and 18F-OC for Neuroendocrine NeoplasmsJiale Hou0Tingting Long1Yi Yang2Dengming Chen3Shuo Hu4Department of Nuclear MedicineDepartment of Nuclear MedicineDepartment of Nuclear MedicineDepartment of Nuclear MedicineDepartment of Nuclear MedicineBackground. To identify parameters based on dual-imaging 18F-AlF-NOTA-octreotide (18F-OC) and 18-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) for predicting the prognosis of neuroendocrine neoplasms (NENs). Materials and Methods. Sixty-six patients (age: mean±standard deviation (SD): 51.8±11.8 years) who underwent both 18F-OC and 18F-FDG PET/CT imaging were enrolled in our retrospective study. The following PET parameters were measured: the maximum standardized uptake value (SUVmax) and the volumetric parameters—18F-OC SSR-derived tumor volume (TV) and somatostatin receptor expression (SRE, TV multiplied by the mean standardized uptake value (SUVmean)) and the 18F-FDG-derived multiple tumor volume (MTV) and tumor lesion glycolysis (TLG). The NETPET grade based on dual-imaging PET images was assessed. Progression-free survival (PFS) was set as an endpoint. Univariate and multivariate survival analyses were performed for PET parameters and clinical tumor data. Results. In the univariate survival analyses of clinical information, PFS was significantly associated with age (>45.5 vs ≤45.5, years, P<0.034) and the presence of bone metastases (P=0.04). Higher values for the 18F-FDG and 18F-OC volumetric parameters and the NETPET grade were adverse factors for PFS according to the dual-imaging PET parameters. In the multivariate survival analysis, the NETPET grade and SRE were predictors of PFS in NEN patients. Conclusion. The NETPET grade is a potential noninvasive prognostic biomarker for NENs.http://dx.doi.org/10.1155/2022/6511179 |
| spellingShingle | Jiale Hou Tingting Long Yi Yang Dengming Chen Shuo Hu The Potential Prognostic Value of Dual-Imaging PET Parameters Based on 18F-FDG and 18F-OC for Neuroendocrine Neoplasms Molecular Imaging |
| title | The Potential Prognostic Value of Dual-Imaging PET Parameters Based on 18F-FDG and 18F-OC for Neuroendocrine Neoplasms |
| title_full | The Potential Prognostic Value of Dual-Imaging PET Parameters Based on 18F-FDG and 18F-OC for Neuroendocrine Neoplasms |
| title_fullStr | The Potential Prognostic Value of Dual-Imaging PET Parameters Based on 18F-FDG and 18F-OC for Neuroendocrine Neoplasms |
| title_full_unstemmed | The Potential Prognostic Value of Dual-Imaging PET Parameters Based on 18F-FDG and 18F-OC for Neuroendocrine Neoplasms |
| title_short | The Potential Prognostic Value of Dual-Imaging PET Parameters Based on 18F-FDG and 18F-OC for Neuroendocrine Neoplasms |
| title_sort | potential prognostic value of dual imaging pet parameters based on 18f fdg and 18f oc for neuroendocrine neoplasms |
| url | http://dx.doi.org/10.1155/2022/6511179 |
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