White matter tracts characteristics in habitual decision-making circuit underlie ritual behaviors in anorexia nervosa
Abstract Anorexia nervosa (AN) is a difficult to treat, pernicious psychiatric disorder that has been linked to decision-making abnormalities. We examined the structural characteristics of habitual and goal-directed decision-making circuits and their connecting white matter tracts in 32 AN and 43 he...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-08-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-95300-3 |
| _version_ | 1818344086985244672 |
|---|---|
| author | Reza Tadayonnejad Fabrizio Pizzagalli Stuart B. Murray Wolfgang M. Pauli Geena Conde Ausaf A. Bari Michael Strober John P. O’Doherty Jamie D. Feusner |
| author_facet | Reza Tadayonnejad Fabrizio Pizzagalli Stuart B. Murray Wolfgang M. Pauli Geena Conde Ausaf A. Bari Michael Strober John P. O’Doherty Jamie D. Feusner |
| author_sort | Reza Tadayonnejad |
| collection | DOAJ |
| description | Abstract Anorexia nervosa (AN) is a difficult to treat, pernicious psychiatric disorder that has been linked to decision-making abnormalities. We examined the structural characteristics of habitual and goal-directed decision-making circuits and their connecting white matter tracts in 32 AN and 43 healthy controls across two independent data sets of adults and adolescents as an explanatory sub-study. Total bilateral premotor/supplementary motor area-putamen tracts in the habit circuit had a significantly higher volume in adults with AN, relative to controls. Positive correlations were found between both the number of tracts and white matter volume (WMV) in the habit circuit, and the severity of ritualistic/compulsive behaviors in adults and adolescents with AN. Moreover, we found a significant influence of the habit circuit WMV on AN ritualistic/compulsive symptom severity, depending on the preoccupations symptom severity levels. These findings suggest that AN is associated with white matter plasticity alterations in the habit circuit. The association between characteristics of habit circuit white matter tracts and AN behavioral symptoms provides support for a circuit based neurobiological model of AN, and identifies the habit circuit as a focus for further investigation to aid in development of novel and more effective treatments based on brain-behavior relationships. |
| first_indexed | 2024-12-13T16:40:54Z |
| format | Article |
| id | doaj.art-74759503c24249e6808c68841e5182e3 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-13T16:40:54Z |
| publishDate | 2021-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-74759503c24249e6808c68841e5182e32022-12-21T23:38:17ZengNature PortfolioScientific Reports2045-23222021-08-0111111210.1038/s41598-021-95300-3White matter tracts characteristics in habitual decision-making circuit underlie ritual behaviors in anorexia nervosaReza Tadayonnejad0Fabrizio Pizzagalli1Stuart B. Murray2Wolfgang M. Pauli3Geena Conde4Ausaf A. Bari5Michael Strober6John P. O’Doherty7Jamie D. Feusner8Division of Neuromodulation, Semel Institute for Neuroscience and Human Behavior, University of California at Los AngelesImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USCDepartment of Psychiatry and the Behavioral Sciences, University of Southern CaliforniaDivision of Humanities and Social Sciences, California Institute of TechnologyDivision of Cognitive Neuroscience, Semel Institute for Neuroscience and Human Behavior, University of California at Los AngelesDepartment of Neursurgery, University of California at Los AngelesDivision of Child and Adolescent, Semel Institute for Neuroscience and Human Behavior, University of California at Los AngelesComputation and Neural Systems Program and Division of Humanities and Social Sciences, California Institute of TechnologyDivision of Cognitive Neuroscience, Semel Institute for Neuroscience and Human Behavior, University of California at Los AngelesAbstract Anorexia nervosa (AN) is a difficult to treat, pernicious psychiatric disorder that has been linked to decision-making abnormalities. We examined the structural characteristics of habitual and goal-directed decision-making circuits and their connecting white matter tracts in 32 AN and 43 healthy controls across two independent data sets of adults and adolescents as an explanatory sub-study. Total bilateral premotor/supplementary motor area-putamen tracts in the habit circuit had a significantly higher volume in adults with AN, relative to controls. Positive correlations were found between both the number of tracts and white matter volume (WMV) in the habit circuit, and the severity of ritualistic/compulsive behaviors in adults and adolescents with AN. Moreover, we found a significant influence of the habit circuit WMV on AN ritualistic/compulsive symptom severity, depending on the preoccupations symptom severity levels. These findings suggest that AN is associated with white matter plasticity alterations in the habit circuit. The association between characteristics of habit circuit white matter tracts and AN behavioral symptoms provides support for a circuit based neurobiological model of AN, and identifies the habit circuit as a focus for further investigation to aid in development of novel and more effective treatments based on brain-behavior relationships.https://doi.org/10.1038/s41598-021-95300-3 |
| spellingShingle | Reza Tadayonnejad Fabrizio Pizzagalli Stuart B. Murray Wolfgang M. Pauli Geena Conde Ausaf A. Bari Michael Strober John P. O’Doherty Jamie D. Feusner White matter tracts characteristics in habitual decision-making circuit underlie ritual behaviors in anorexia nervosa Scientific Reports |
| title | White matter tracts characteristics in habitual decision-making circuit underlie ritual behaviors in anorexia nervosa |
| title_full | White matter tracts characteristics in habitual decision-making circuit underlie ritual behaviors in anorexia nervosa |
| title_fullStr | White matter tracts characteristics in habitual decision-making circuit underlie ritual behaviors in anorexia nervosa |
| title_full_unstemmed | White matter tracts characteristics in habitual decision-making circuit underlie ritual behaviors in anorexia nervosa |
| title_short | White matter tracts characteristics in habitual decision-making circuit underlie ritual behaviors in anorexia nervosa |
| title_sort | white matter tracts characteristics in habitual decision making circuit underlie ritual behaviors in anorexia nervosa |
| url | https://doi.org/10.1038/s41598-021-95300-3 |
| work_keys_str_mv | AT rezatadayonnejad whitemattertractscharacteristicsinhabitualdecisionmakingcircuitunderlieritualbehaviorsinanorexianervosa AT fabriziopizzagalli whitemattertractscharacteristicsinhabitualdecisionmakingcircuitunderlieritualbehaviorsinanorexianervosa AT stuartbmurray whitemattertractscharacteristicsinhabitualdecisionmakingcircuitunderlieritualbehaviorsinanorexianervosa AT wolfgangmpauli whitemattertractscharacteristicsinhabitualdecisionmakingcircuitunderlieritualbehaviorsinanorexianervosa AT geenaconde whitemattertractscharacteristicsinhabitualdecisionmakingcircuitunderlieritualbehaviorsinanorexianervosa AT ausafabari whitemattertractscharacteristicsinhabitualdecisionmakingcircuitunderlieritualbehaviorsinanorexianervosa AT michaelstrober whitemattertractscharacteristicsinhabitualdecisionmakingcircuitunderlieritualbehaviorsinanorexianervosa AT johnpodoherty whitemattertractscharacteristicsinhabitualdecisionmakingcircuitunderlieritualbehaviorsinanorexianervosa AT jamiedfeusner whitemattertractscharacteristicsinhabitualdecisionmakingcircuitunderlieritualbehaviorsinanorexianervosa |