Behavioral impairment and cognition in Thai adolescents affected by HIV
Abstract Background Cognitive and behavioral impairment are common in children living with perinatally acquired HIV (pHIV) and children exposed to HIV in utero but uninfected (HEU). Methods We sought to determine the prevalence of adverse behavioral symptomatology using a Thai-translated and valida...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2021-01-01
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| Series: | Cambridge Prisms: Global Mental Health |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2054425121000017/type/journal_article |
| _version_ | 1811156113746296832 |
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| author | Payal B. Patel Andrew Belden Ryan Handoko Thanyawee Puthanakit Stephen Kerr Pope Kosalaraksa Pradthana Ounchanum Suparat Kanjanavanit Linda Aurpibul Chaiwat Ngampiyasakul Wicharn Luesomboon Claude A. Mellins Kathleen Malee Jintanat Ananworanich Robert Paul |
| author_facet | Payal B. Patel Andrew Belden Ryan Handoko Thanyawee Puthanakit Stephen Kerr Pope Kosalaraksa Pradthana Ounchanum Suparat Kanjanavanit Linda Aurpibul Chaiwat Ngampiyasakul Wicharn Luesomboon Claude A. Mellins Kathleen Malee Jintanat Ananworanich Robert Paul |
| author_sort | Payal B. Patel |
| collection | DOAJ |
| description | Abstract
Background
Cognitive and behavioral impairment are common in children living with perinatally acquired HIV (pHIV) and children exposed to HIV in utero but uninfected (HEU).
Methods
We sought to determine the prevalence of adverse behavioral symptomatology using a Thai-translated and validated version of the SNAP-IV questionnaire and assess cognitive function utilizing the Children's Color Trails Test, Delis-Kaplan Executive Function System, and the Wechsler Intelligence Scales, in our cohort of Thai adolescents (10–20 years old) with well-controlled pHIV compared to HEU and HIV-unexposed, uninfected youth. We then evaluated the interaction between HIV status, behavioral impairment, and executive function outcomes independent of demographic variables.
Results
After controlling for demographic factors of age and household income, adolescents with pHIV had higher inattentive symptomatology and poorer neuropsychological test scores compared to uninfected controls. Significant interactions were found between inattention and executive function across multiple neurocognitive tests.
Conclusions
Behavioral impairment and poor executive functioning are present in adolescents with well-controlled pHIV compared to HIV-uninfected matched peers. The SNAP-IV questionnaire may be a useful tool to identify those with attentional impairment who may benefit from further cognitive testing in resource-limited settings.
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| first_indexed | 2024-04-10T04:45:02Z |
| format | Article |
| id | doaj.art-7475f464887e433bb77a409d1d7c15df |
| institution | Directory Open Access Journal |
| issn | 2054-4251 |
| language | English |
| last_indexed | 2024-04-10T04:45:02Z |
| publishDate | 2021-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Cambridge Prisms: Global Mental Health |
| spelling | doaj.art-7475f464887e433bb77a409d1d7c15df2023-03-09T12:35:44ZengCambridge University PressCambridge Prisms: Global Mental Health2054-42512021-01-01810.1017/gmh.2021.1Behavioral impairment and cognition in Thai adolescents affected by HIVPayal B. Patel0https://orcid.org/0000-0002-2984-9484Andrew Belden1Ryan Handoko2Thanyawee Puthanakit3Stephen Kerr4Pope Kosalaraksa5Pradthana Ounchanum6Suparat Kanjanavanit7Linda Aurpibul8Chaiwat Ngampiyasakul9Wicharn Luesomboon10Claude A. Mellins11Kathleen Malee12Jintanat Ananworanich13Robert Paul14Department of Neurology, University of Washington, Seattle, WA, USAUniversity of Missouri, St. Louis, St. Louis, MO, USAYale University, New Haven, CT, USADepartment of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandFaculty of Medicine, HIV-NAT, The Thai Red Cross AIDS Research Center and Biostatistics Centre, Chulalongkorn University, Bangkok, ThailandDepartment of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandChiangrai Prachanukroh Hospital, Chiang Rai, ThailandNakornping Hospital, Chiang Mai, ThailandResearch Institute for Health Sciences (RIHES), Chiang Mai University, ThailandPrapokklao Hospital, Chantaburi, ThailandQueen Savang Vadhana Memorial Hospital, Chonburi, ThailandHIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute, and Columbia University, New York City, NY, USADepartment of Psychiatry and Behavioral Science, Northwestern University Feinberg School of Medicine, Chicago, IL, USABill and Melinda Gates Medical Research Institute, Cambridge, MA, USAMissouri Institute of Mental Health, University of Missouri-St. Louis, Saint Louis, MO, USAAbstract Background Cognitive and behavioral impairment are common in children living with perinatally acquired HIV (pHIV) and children exposed to HIV in utero but uninfected (HEU). Methods We sought to determine the prevalence of adverse behavioral symptomatology using a Thai-translated and validated version of the SNAP-IV questionnaire and assess cognitive function utilizing the Children's Color Trails Test, Delis-Kaplan Executive Function System, and the Wechsler Intelligence Scales, in our cohort of Thai adolescents (10–20 years old) with well-controlled pHIV compared to HEU and HIV-unexposed, uninfected youth. We then evaluated the interaction between HIV status, behavioral impairment, and executive function outcomes independent of demographic variables. Results After controlling for demographic factors of age and household income, adolescents with pHIV had higher inattentive symptomatology and poorer neuropsychological test scores compared to uninfected controls. Significant interactions were found between inattention and executive function across multiple neurocognitive tests. Conclusions Behavioral impairment and poor executive functioning are present in adolescents with well-controlled pHIV compared to HIV-uninfected matched peers. The SNAP-IV questionnaire may be a useful tool to identify those with attentional impairment who may benefit from further cognitive testing in resource-limited settings. https://www.cambridge.org/core/product/identifier/S2054425121000017/type/journal_articleAdolescentsbehavioral healthcognitionperinatal HIV |
| spellingShingle | Payal B. Patel Andrew Belden Ryan Handoko Thanyawee Puthanakit Stephen Kerr Pope Kosalaraksa Pradthana Ounchanum Suparat Kanjanavanit Linda Aurpibul Chaiwat Ngampiyasakul Wicharn Luesomboon Claude A. Mellins Kathleen Malee Jintanat Ananworanich Robert Paul Behavioral impairment and cognition in Thai adolescents affected by HIV Cambridge Prisms: Global Mental Health Adolescents behavioral health cognition perinatal HIV |
| title | Behavioral impairment and cognition in Thai adolescents affected by HIV |
| title_full | Behavioral impairment and cognition in Thai adolescents affected by HIV |
| title_fullStr | Behavioral impairment and cognition in Thai adolescents affected by HIV |
| title_full_unstemmed | Behavioral impairment and cognition in Thai adolescents affected by HIV |
| title_short | Behavioral impairment and cognition in Thai adolescents affected by HIV |
| title_sort | behavioral impairment and cognition in thai adolescents affected by hiv |
| topic | Adolescents behavioral health cognition perinatal HIV |
| url | https://www.cambridge.org/core/product/identifier/S2054425121000017/type/journal_article |
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