Respiratory syncytial virus associated hospitalizations in children with congenital diaphragmatic hernia
Background: To evaluate the risk of RSV infection in infants and children with congenital diaphragmatic hernia (CDH) over two consecutive RSV seasons. Methods: Retrospective, single-center cohort study from southern Austria including infants with CDH born between 1993 and 2012. Infants were retrieve...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-04-01
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| Series: | Pediatrics and Neonatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957217301596 |
| _version_ | 1818157316246077440 |
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| author | Bernhard Resch Krisztina Liziczai Friedrich Reiterer Thomas Freidl Michaela Haim Berndt Urlesberger |
| author_facet | Bernhard Resch Krisztina Liziczai Friedrich Reiterer Thomas Freidl Michaela Haim Berndt Urlesberger |
| author_sort | Bernhard Resch |
| collection | DOAJ |
| description | Background: To evaluate the risk of RSV infection in infants and children with congenital diaphragmatic hernia (CDH) over two consecutive RSV seasons. Methods: Retrospective, single-center cohort study from southern Austria including infants with CDH born between 1993 and 2012. Infants were retrieved by searching via ICD-10 codes Q79.0 and Q79.1 and by using a local electronic database. Children were followed over 2 years of life including at least two consecutive RSV seasons (November to April). We also defined a group of hypothetical RSV infections with the following criteria: 70% of the admissions due to a respiratory infection (diagnosis of bronchiolitis and/or LRI score ≥3) during the RSV seasons over the first 2 years of life, when no test for RSV was performed. Results: Twenty-nine of 45 infants with CDH comprised the study population (6 were lost to follow-up and 10 died) of whom 9 (31%) exhibited 17 hospitalizations due to respiratory illness. Two hospitalized infants (6.9% of the study population) tested RSV positive, one during the first and the other during the second RSV season. Nine of 29 infants (31%) had documentation of palivizumab prophylaxis, none (0%) had proven RSV hospitalization compared to 1 of 20 (5%) without prophylaxis during the first RSV season (p = 0.256). Including the hypothetical cases, we calculated 0 of 9 (0%) in the palivizumab group and 4 of 20 (20%) in the group without prophylaxis (p = 0.079). Conclusions: We found a moderate rate of proven RSV hospitalizations in infants with CDH, and palivizumab prophylaxis led to a non-significant reduction of proven and hypothesized RSV hospitalizations. Key Words: respiratory syncytial virus, congenital diaphragmatic hernia, respiratory tract infection, hospitalization |
| first_indexed | 2024-12-11T15:12:15Z |
| format | Article |
| id | doaj.art-74768937997f4526991478b4b97e0195 |
| institution | Directory Open Access Journal |
| issn | 1875-9572 |
| language | English |
| last_indexed | 2024-12-11T15:12:15Z |
| publishDate | 2018-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj.art-74768937997f4526991478b4b97e01952022-12-22T01:00:42ZengElsevierPediatrics and Neonatology1875-95722018-04-01592184188Respiratory syncytial virus associated hospitalizations in children with congenital diaphragmatic herniaBernhard Resch0Krisztina Liziczai1Friedrich Reiterer2Thomas Freidl3Michaela Haim4Berndt Urlesberger5Division of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Austria; Research Unit for Neonatal Infectious Diseases and Epidemiology, Medical University of Graz, Austria; Corresponding author. Division of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Auenbruggerplatz 34/2, 8036 Graz, Austria. Fax: +43 316 385 12678.Research Unit for Neonatal Infectious Diseases and Epidemiology, Medical University of Graz, AustriaDivision of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, AustriaDivision of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, AustriaDivision of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, AustriaDivision of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, AustriaBackground: To evaluate the risk of RSV infection in infants and children with congenital diaphragmatic hernia (CDH) over two consecutive RSV seasons. Methods: Retrospective, single-center cohort study from southern Austria including infants with CDH born between 1993 and 2012. Infants were retrieved by searching via ICD-10 codes Q79.0 and Q79.1 and by using a local electronic database. Children were followed over 2 years of life including at least two consecutive RSV seasons (November to April). We also defined a group of hypothetical RSV infections with the following criteria: 70% of the admissions due to a respiratory infection (diagnosis of bronchiolitis and/or LRI score ≥3) during the RSV seasons over the first 2 years of life, when no test for RSV was performed. Results: Twenty-nine of 45 infants with CDH comprised the study population (6 were lost to follow-up and 10 died) of whom 9 (31%) exhibited 17 hospitalizations due to respiratory illness. Two hospitalized infants (6.9% of the study population) tested RSV positive, one during the first and the other during the second RSV season. Nine of 29 infants (31%) had documentation of palivizumab prophylaxis, none (0%) had proven RSV hospitalization compared to 1 of 20 (5%) without prophylaxis during the first RSV season (p = 0.256). Including the hypothetical cases, we calculated 0 of 9 (0%) in the palivizumab group and 4 of 20 (20%) in the group without prophylaxis (p = 0.079). Conclusions: We found a moderate rate of proven RSV hospitalizations in infants with CDH, and palivizumab prophylaxis led to a non-significant reduction of proven and hypothesized RSV hospitalizations. Key Words: respiratory syncytial virus, congenital diaphragmatic hernia, respiratory tract infection, hospitalizationhttp://www.sciencedirect.com/science/article/pii/S1875957217301596 |
| spellingShingle | Bernhard Resch Krisztina Liziczai Friedrich Reiterer Thomas Freidl Michaela Haim Berndt Urlesberger Respiratory syncytial virus associated hospitalizations in children with congenital diaphragmatic hernia Pediatrics and Neonatology |
| title | Respiratory syncytial virus associated hospitalizations in children with congenital diaphragmatic hernia |
| title_full | Respiratory syncytial virus associated hospitalizations in children with congenital diaphragmatic hernia |
| title_fullStr | Respiratory syncytial virus associated hospitalizations in children with congenital diaphragmatic hernia |
| title_full_unstemmed | Respiratory syncytial virus associated hospitalizations in children with congenital diaphragmatic hernia |
| title_short | Respiratory syncytial virus associated hospitalizations in children with congenital diaphragmatic hernia |
| title_sort | respiratory syncytial virus associated hospitalizations in children with congenital diaphragmatic hernia |
| url | http://www.sciencedirect.com/science/article/pii/S1875957217301596 |
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