Prenatal exposures to organophosphate ester metabolite mixtures and children’s neurobehavioral outcomes in the MADRES pregnancy cohort
Abstract Background Evidence suggests organophosphate esters (OPEs) are neurotoxic; however, the epidemiological literature remains scarce. We investigated whether prenatal exposures to OPEs were associated with child neurobehavior in the MADRES cohort. Methods We measured nine OPE metabolites in 20...
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BMC
2023-09-01
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| Series: | Environmental Health |
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| Online Access: | https://doi.org/10.1186/s12940-023-01017-3 |
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| author | Ixel Hernandez-Castro Sandrah P. Eckel Caitlin G. Howe Zhongzheng Niu Kurunthachalam Kannan Morgan Robinson Helen B. Foley Tingyu Yang Mario J. Vigil Xinci Chen Brendan Grubbs Deborah Lerner Nathana Lurvey Laila Al-Marayati Rima Habre Genevieve F. Dunton Shohreh F. Farzan Max T. Aung Carrie V. Breton Theresa M. Bastain |
| author_facet | Ixel Hernandez-Castro Sandrah P. Eckel Caitlin G. Howe Zhongzheng Niu Kurunthachalam Kannan Morgan Robinson Helen B. Foley Tingyu Yang Mario J. Vigil Xinci Chen Brendan Grubbs Deborah Lerner Nathana Lurvey Laila Al-Marayati Rima Habre Genevieve F. Dunton Shohreh F. Farzan Max T. Aung Carrie V. Breton Theresa M. Bastain |
| author_sort | Ixel Hernandez-Castro |
| collection | DOAJ |
| description | Abstract Background Evidence suggests organophosphate esters (OPEs) are neurotoxic; however, the epidemiological literature remains scarce. We investigated whether prenatal exposures to OPEs were associated with child neurobehavior in the MADRES cohort. Methods We measured nine OPE metabolites in 204 maternal urine samples (gestational age at collection: 31.4 ± 1.8 weeks). Neurobehavior problems were assessed among 36-month-old children using the Child Behavior Checklist’s (CBCL) three composite scales [internalizing, externalizing, and total problems]. We examined associations between tertiles of prenatal OPE metabolites (> 50% detection) and detect/non-detect categories (< 50% detection) and CBCL composite scales using linear regression and generalized additive models. We also examined mixtures for widely detected OPEs (n = 5) using Bayesian kernel machine regression. Results Maternal participants with detectable versus non-detectable levels of bis(2-methylphenyl) phosphate (BMPP) had children with 42% (95% CI: 4%, 96%) higher externalizing, 45% (-2%, 114%) higher internalizing, and 35% (3%, 78%) higher total problems. Participants in the second versus first tertile of bis(butoxethyl) phosphate (BBOEP) had children with 43% (-1%, 109%) higher externalizing scores. Bis(1-chloro-2-propyl) phosphate (BCIPP) and child sex had a statistically significant interaction in internalizing (p = 0.02) and total problems (p = 0.03) models, with 120% (23%, 295%) and 57% (6%, 134%) higher scores in the third versus first BCIPP tertile among males. Among females, detectable vs non-detectable levels of prenatal BMPP were associated with 69% higher externalizing scores (5%, 170%) while the third versus first tertile of prenatal BBOEP was associated with 45% lower total problems (-68%, -6%). Although the metabolite mixture and each CBCL outcome had null associations, we observed marginal associations between di-n-butyl phosphate and di-isobutyl phosphate (DNBP + DIBP) and higher internalizing scores (0.15; 95% CrI: -0.02, 0.32), holding other metabolites at their median. Conclusions Our results generally suggest adverse and sex-specific effects of prenatal exposure to previously understudied OPEs on neurobehavioral outcomes in 36-month children, providing evidence of potential OPE neurotoxicity. |
| first_indexed | 2024-03-09T14:57:09Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1476-069X |
| language | English |
| last_indexed | 2024-03-09T14:57:09Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Environmental Health |
| spelling | doaj.art-7478b4e305cb4797b175bdf2a9ed972a2023-11-26T14:07:49ZengBMCEnvironmental Health1476-069X2023-09-0122112110.1186/s12940-023-01017-3Prenatal exposures to organophosphate ester metabolite mixtures and children’s neurobehavioral outcomes in the MADRES pregnancy cohortIxel Hernandez-Castro0Sandrah P. Eckel1Caitlin G. Howe2Zhongzheng Niu3Kurunthachalam Kannan4Morgan Robinson5Helen B. Foley6Tingyu Yang7Mario J. Vigil8Xinci Chen9Brendan Grubbs10Deborah Lerner11Nathana Lurvey12Laila Al-Marayati13Rima Habre14Genevieve F. Dunton15Shohreh F. Farzan16Max T. Aung17Carrie V. Breton18Theresa M. Bastain19Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern CaliforniaDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern CaliforniaDepartment of Epidemiology, Geisel School of Medicine at DartmouthDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern CaliforniaWadsworth Center, New York State Department of HealthWadsworth Center, New York State Department of HealthDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern CaliforniaDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern CaliforniaDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern CaliforniaDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern CaliforniaDepartment of Obstetrics and Gynecology, Keck School of Medicine, University of Southern CaliforniaEisner HealthEisner HealthDepartment of Obstetrics and Gynecology, Keck School of Medicine, University of Southern CaliforniaDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern CaliforniaDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern CaliforniaDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern CaliforniaDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern CaliforniaDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern CaliforniaDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern CaliforniaAbstract Background Evidence suggests organophosphate esters (OPEs) are neurotoxic; however, the epidemiological literature remains scarce. We investigated whether prenatal exposures to OPEs were associated with child neurobehavior in the MADRES cohort. Methods We measured nine OPE metabolites in 204 maternal urine samples (gestational age at collection: 31.4 ± 1.8 weeks). Neurobehavior problems were assessed among 36-month-old children using the Child Behavior Checklist’s (CBCL) three composite scales [internalizing, externalizing, and total problems]. We examined associations between tertiles of prenatal OPE metabolites (> 50% detection) and detect/non-detect categories (< 50% detection) and CBCL composite scales using linear regression and generalized additive models. We also examined mixtures for widely detected OPEs (n = 5) using Bayesian kernel machine regression. Results Maternal participants with detectable versus non-detectable levels of bis(2-methylphenyl) phosphate (BMPP) had children with 42% (95% CI: 4%, 96%) higher externalizing, 45% (-2%, 114%) higher internalizing, and 35% (3%, 78%) higher total problems. Participants in the second versus first tertile of bis(butoxethyl) phosphate (BBOEP) had children with 43% (-1%, 109%) higher externalizing scores. Bis(1-chloro-2-propyl) phosphate (BCIPP) and child sex had a statistically significant interaction in internalizing (p = 0.02) and total problems (p = 0.03) models, with 120% (23%, 295%) and 57% (6%, 134%) higher scores in the third versus first BCIPP tertile among males. Among females, detectable vs non-detectable levels of prenatal BMPP were associated with 69% higher externalizing scores (5%, 170%) while the third versus first tertile of prenatal BBOEP was associated with 45% lower total problems (-68%, -6%). Although the metabolite mixture and each CBCL outcome had null associations, we observed marginal associations between di-n-butyl phosphate and di-isobutyl phosphate (DNBP + DIBP) and higher internalizing scores (0.15; 95% CrI: -0.02, 0.32), holding other metabolites at their median. Conclusions Our results generally suggest adverse and sex-specific effects of prenatal exposure to previously understudied OPEs on neurobehavioral outcomes in 36-month children, providing evidence of potential OPE neurotoxicity.https://doi.org/10.1186/s12940-023-01017-3MixturesOPEOrganophosphate estersOPFRsNeurobehaviorEarly childhood |
| spellingShingle | Ixel Hernandez-Castro Sandrah P. Eckel Caitlin G. Howe Zhongzheng Niu Kurunthachalam Kannan Morgan Robinson Helen B. Foley Tingyu Yang Mario J. Vigil Xinci Chen Brendan Grubbs Deborah Lerner Nathana Lurvey Laila Al-Marayati Rima Habre Genevieve F. Dunton Shohreh F. Farzan Max T. Aung Carrie V. Breton Theresa M. Bastain Prenatal exposures to organophosphate ester metabolite mixtures and children’s neurobehavioral outcomes in the MADRES pregnancy cohort Environmental Health Mixtures OPE Organophosphate esters OPFRs Neurobehavior Early childhood |
| title | Prenatal exposures to organophosphate ester metabolite mixtures and children’s neurobehavioral outcomes in the MADRES pregnancy cohort |
| title_full | Prenatal exposures to organophosphate ester metabolite mixtures and children’s neurobehavioral outcomes in the MADRES pregnancy cohort |
| title_fullStr | Prenatal exposures to organophosphate ester metabolite mixtures and children’s neurobehavioral outcomes in the MADRES pregnancy cohort |
| title_full_unstemmed | Prenatal exposures to organophosphate ester metabolite mixtures and children’s neurobehavioral outcomes in the MADRES pregnancy cohort |
| title_short | Prenatal exposures to organophosphate ester metabolite mixtures and children’s neurobehavioral outcomes in the MADRES pregnancy cohort |
| title_sort | prenatal exposures to organophosphate ester metabolite mixtures and children s neurobehavioral outcomes in the madres pregnancy cohort |
| topic | Mixtures OPE Organophosphate esters OPFRs Neurobehavior Early childhood |
| url | https://doi.org/10.1186/s12940-023-01017-3 |
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